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Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC-FTIR microspectroscopic technique.
Drug Discov Today. 2017 04; 22(4):718-728.DD

Abstract

Various methods and analytical techniques for the preparation and identification of pharmaceutical co-crystals have been applied, but these operations require considerable time for the screening and preparation of co-crystals. In this review, a powerful method that combines Fourier-transform infrared (FTIR) microspectroscopy with thermal analysis is introduced. This unique one-step real-time differential scanning calorimetry (DSC)-FTIR microspectroscopic approach has been successfully applied to simultaneously and directly screen and detect pharmaceutical co-crystal formation in systems such as indomethacin-saccharin, indomethacin-nicotinamide, carbamazepine-glutaric-acid, metaxalone-succinic-acid and piroxicam-saccharin. This powerful one-step DSC-FTIR combined technique provides an easy and direct method for one-step screening and qualitative detection of co-crystal formation in real time.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lin SY
Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsin Chu, Taiwan, ROC. Electronic address: sylin@mail.ypu.edu.tw.

MeSH

Calorimetry, Differential ScanningCrystallizationPharmaceutical PreparationsSpectroscopy, Fourier Transform Infrared

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27979712

Citation

Lin, Shan-Yang. "Simultaneous Screening and Detection of Pharmaceutical Co-crystals By the One-step DSC-FTIR Microspectroscopic Technique." Drug Discovery Today, vol. 22, no. 4, 2017, pp. 718-728.
Lin SY. Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC-FTIR microspectroscopic technique. Drug Discov Today. 2017;22(4):718-728.
Lin, S. Y. (2017). Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC-FTIR microspectroscopic technique. Drug Discovery Today, 22(4), 718-728. https://doi.org/10.1016/j.drudis.2016.12.001
Lin SY. Simultaneous Screening and Detection of Pharmaceutical Co-crystals By the One-step DSC-FTIR Microspectroscopic Technique. Drug Discov Today. 2017;22(4):718-728. PubMed PMID: 27979712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC-FTIR microspectroscopic technique. A1 - Lin,Shan-Yang, Y1 - 2016/12/12/ PY - 2016/10/07/received PY - 2016/11/07/revised PY - 2016/12/02/accepted PY - 2016/12/17/pubmed PY - 2018/1/31/medline PY - 2016/12/17/entrez SP - 718 EP - 728 JF - Drug discovery today JO - Drug Discov Today VL - 22 IS - 4 N2 - Various methods and analytical techniques for the preparation and identification of pharmaceutical co-crystals have been applied, but these operations require considerable time for the screening and preparation of co-crystals. In this review, a powerful method that combines Fourier-transform infrared (FTIR) microspectroscopy with thermal analysis is introduced. This unique one-step real-time differential scanning calorimetry (DSC)-FTIR microspectroscopic approach has been successfully applied to simultaneously and directly screen and detect pharmaceutical co-crystal formation in systems such as indomethacin-saccharin, indomethacin-nicotinamide, carbamazepine-glutaric-acid, metaxalone-succinic-acid and piroxicam-saccharin. This powerful one-step DSC-FTIR combined technique provides an easy and direct method for one-step screening and qualitative detection of co-crystal formation in real time. SN - 1878-5832 UR - https://www.unboundmedicine.com/medline/citation/27979712/Simultaneous_screening_and_detection_of_pharmaceutical_co_crystals_by_the_one_step_DSC_FTIR_microspectroscopic_technique_ DB - PRIME DP - Unbound Medicine ER -