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Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression.
Korean J Ophthalmol. 2016 Dec; 30(6):451-458.KJ

Abstract

PURPOSE

To investigate the use of ganglion cell inner plexiform layer (GC-IPL) thickness, as measured by spectral domain optical coherence tomography, to detect central visual field (VF) progression.

METHODS

This study included 384 eyes from 384 patients (219 preperimetric and 165 perimetric glaucomatous eyes; average follow-up, 4.3 years). Photographic assessment of retinal nerve fiber layer (RNFL) and serial VF analysis were performed to detect glaucoma progression in the central (within 10°) area. Study inclusion required at least five serial spectral domain optical coherence tomography exams at different visits. The long-term test-retest variability of average GC-IPL thicknesses was calculated in 110 stable preperimetric glaucomatous eyes. The sensitivity and specificity of GC-IPL measurements for the detection of central VF progression were calculated in an event-based analysis using the calculated variability as a cut-off and were compared with those of central RNFL photographic assessment.

RESULTS

The intersession test-retest variability, defined as the 95% confidence interval, was 1.76 µm for average GC-IPL thickness. The sensitivity and specificity of the average GC-IPL thickness for detecting central VF progression were 60.7% and 78.9%, respectively. Among six sectors, the inferonasal GC-IPL sector showed the highest sensitivity (53.6%). The sensitivity of the ≥1 sector GC-IPL to detect central VF progression was significantly higher than that of central RNFL photographic progression (p = 0.013). Other GC-IPL parameters showed comparable sensitivity and specificity to detect central VF progression compared with RNFL photographic progression.

CONCLUSIONS

Serial GC-IPL measurements show comparable performance in the detection of central glaucomatous VF progression to RNFL photographic assessment.

Authors+Show Affiliations

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27980364

Citation

Moon, Haein, et al. "Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression." Korean Journal of Ophthalmology : KJO, vol. 30, no. 6, 2016, pp. 451-458.
Moon H, Lee JY, Sung KR, et al. Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression. Korean J Ophthalmol. 2016;30(6):451-458.
Moon, H., Lee, J. Y., Sung, K. R., & Lee, J. E. (2016). Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression. Korean Journal of Ophthalmology : KJO, 30(6), 451-458.
Moon H, et al. Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression. Korean J Ophthalmol. 2016;30(6):451-458. PubMed PMID: 27980364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular Ganglion Cell Layer Assessment to Detect Glaucomatous Central Visual Field Progression. AU - Moon,Haein, AU - Lee,Jin Young, AU - Sung,Kyung Rim, AU - Lee,Jong Eun, Y1 - 2016/12/06/ PY - 2016/05/16/received PY - 2016/06/15/accepted PY - 2016/12/17/entrez PY - 2016/12/17/pubmed PY - 2017/3/16/medline KW - Central visual field KW - Glaucoma KW - Optical coherence tomography KW - Retinal ganglion cell SP - 451 EP - 458 JF - Korean journal of ophthalmology : KJO JO - Korean J Ophthalmol VL - 30 IS - 6 N2 - PURPOSE: To investigate the use of ganglion cell inner plexiform layer (GC-IPL) thickness, as measured by spectral domain optical coherence tomography, to detect central visual field (VF) progression. METHODS: This study included 384 eyes from 384 patients (219 preperimetric and 165 perimetric glaucomatous eyes; average follow-up, 4.3 years). Photographic assessment of retinal nerve fiber layer (RNFL) and serial VF analysis were performed to detect glaucoma progression in the central (within 10°) area. Study inclusion required at least five serial spectral domain optical coherence tomography exams at different visits. The long-term test-retest variability of average GC-IPL thicknesses was calculated in 110 stable preperimetric glaucomatous eyes. The sensitivity and specificity of GC-IPL measurements for the detection of central VF progression were calculated in an event-based analysis using the calculated variability as a cut-off and were compared with those of central RNFL photographic assessment. RESULTS: The intersession test-retest variability, defined as the 95% confidence interval, was 1.76 µm for average GC-IPL thickness. The sensitivity and specificity of the average GC-IPL thickness for detecting central VF progression were 60.7% and 78.9%, respectively. Among six sectors, the inferonasal GC-IPL sector showed the highest sensitivity (53.6%). The sensitivity of the ≥1 sector GC-IPL to detect central VF progression was significantly higher than that of central RNFL photographic progression (p = 0.013). Other GC-IPL parameters showed comparable sensitivity and specificity to detect central VF progression compared with RNFL photographic progression. CONCLUSIONS: Serial GC-IPL measurements show comparable performance in the detection of central glaucomatous VF progression to RNFL photographic assessment. SN - 2092-9382 UR - https://www.unboundmedicine.com/medline/citation/27980364/Macular_Ganglion_Cell_Layer_Assessment_to_Detect_Glaucomatous_Central_Visual_Field_Progression_ L2 - https://ekjo.org/DOIx.php?id=10.3341/kjo.2016.30.6.451 DB - PRIME DP - Unbound Medicine ER -