Abstract
SCOPE
Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma.
METHODS AND RESULTS
A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D.
CONCLUSION
This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.
TY - JOUR
T1 - Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies.
AU - Song,Huihui,
AU - Yang,Lei,
AU - Jia,Chongqi,
Y1 - 2017/03/21/
PY - 2016/07/28/received
PY - 2016/12/02/revised
PY - 2016/12/06/accepted
PY - 2016/12/17/pubmed
PY - 2017/12/28/medline
PY - 2016/12/17/entrez
KW - Childhood asthma
KW - Maternal
KW - Meta-analysis
KW - Vitamin D
JF - Molecular nutrition & food research
JO - Mol Nutr Food Res
VL - 61
IS - 5
N2 - SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D. CONCLUSION: This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.
SN - 1613-4133
UR - https://www.unboundmedicine.com/medline/citation/27981740/Maternal_vitamin_D_status_during_pregnancy_and_risk_of_childhood_asthma:_A_meta_analysis_of_prospective_studies_
DB - PRIME
DP - Unbound Medicine
ER -