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Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies.
Mol Nutr Food Res 2017; 61(5)MN

Abstract

SCOPE

Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma.

METHODS AND RESULTS

A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D.

CONCLUSION

This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27981740

Citation

Song, Huihui, et al. "Maternal Vitamin D Status During Pregnancy and Risk of Childhood Asthma: a Meta-analysis of Prospective Studies." Molecular Nutrition & Food Research, vol. 61, no. 5, 2017.
Song H, Yang L, Jia C. Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. Mol Nutr Food Res. 2017;61(5).
Song, H., Yang, L., & Jia, C. (2017). Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. Molecular Nutrition & Food Research, 61(5), doi:10.1002/mnfr.201600657.
Song H, Yang L, Jia C. Maternal Vitamin D Status During Pregnancy and Risk of Childhood Asthma: a Meta-analysis of Prospective Studies. Mol Nutr Food Res. 2017;61(5) PubMed PMID: 27981740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. AU - Song,Huihui, AU - Yang,Lei, AU - Jia,Chongqi, Y1 - 2017/03/21/ PY - 2016/07/28/received PY - 2016/12/02/revised PY - 2016/12/06/accepted PY - 2016/12/17/pubmed PY - 2017/12/28/medline PY - 2016/12/17/entrez KW - Childhood asthma KW - Maternal KW - Meta-analysis KW - Vitamin D JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 61 IS - 5 N2 - SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D. CONCLUSION: This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/27981740/Maternal_vitamin_D_status_during_pregnancy_and_risk_of_childhood_asthma:_A_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1002/mnfr.201600657 DB - PRIME DP - Unbound Medicine ER -