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Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies.

Abstract

SCOPE

Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma.

METHODS AND RESULTS

A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D.

CONCLUSION

This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.

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    Authors+Show Affiliations

    Song H
    ,

    Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.

    Yang L
    ,

    Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.

    Jia C

    Department of Epidemiology, School of Public Health, Shandong University, Jinan, P.R. China.

    Source

    MeSH

    Asthma
    Child
    Dietary Supplements
    Female
    Humans
    Maternal Nutritional Physiological Phenomena
    Pregnancy
    Risk Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    27981740

    Citation

    Song, Huihui, et al. "Maternal Vitamin D Status During Pregnancy and Risk of Childhood Asthma: a Meta-analysis of Prospective Studies." Molecular Nutrition & Food Research, vol. 61, no. 5, 2017.
    Song H, Yang L, Jia C. Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. Mol Nutr Food Res. 2017;61(5).
    Song, H., Yang, L., & Jia, C. (2017). Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. Molecular Nutrition & Food Research, 61(5), doi:10.1002/mnfr.201600657.
    Song H, Yang L, Jia C. Maternal Vitamin D Status During Pregnancy and Risk of Childhood Asthma: a Meta-analysis of Prospective Studies. Mol Nutr Food Res. 2017;61(5) PubMed PMID: 27981740.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta-analysis of prospective studies. AU - Song,Huihui, AU - Yang,Lei, AU - Jia,Chongqi, Y1 - 2017/03/21/ PY - 2016/07/28/received PY - 2016/12/02/revised PY - 2016/12/06/accepted PY - 2016/12/17/pubmed PY - 2017/12/28/medline PY - 2016/12/17/entrez KW - Childhood asthma KW - Maternal KW - Meta-analysis KW - Vitamin D JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 61 IS - 5 N2 - SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose-response relationship was assessed by restricted cubic spline model. Fifteen prospective studies with 12 758 participants and 1795 cases were included in the meta-analysis. The pooled relative risk of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose-response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (Pnonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D. CONCLUSION: This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/27981740/Maternal_vitamin_D_status_during_pregnancy_and_risk_of_childhood_asthma:_A_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1002/mnfr.201600657 DB - PRIME DP - Unbound Medicine ER -