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Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities.
Chem Biodivers. 2017 May; 14(5)CB

Abstract

Phenolic compounds and different biological activities of the dry MeOH extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides, and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract. The extracts (p.o.) were tested for anti-edematous activity in a model of carrageenan (i.pl.) induced rat paw edema. Antioxidant activity of the extracts was assessed by FRAP assay and DPPH and • OH radicals scavenging tests. Antimicrobial activity was investigated using broth microdilution test against five Gram-positive and three Gram-negative bacteria, as well as against two strains of Candida albicans. The polyphenol-richer flower extract exerted higher anti-edematous and antioxidant activities. The herb extract exhibited better antimicrobial effect against Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa, while against other tested microorganisms, the activity of both extracts was identical. Demonstrated biological activities of L. zernyi flower and herb extracts represent a good basis for their further investigation as potential new herbal medicinal raw materials.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade. Receptor Research Laboratories, Nuclear Receptor Lab, VIB Medical Biotechnology Center, VIB, Ghent University, Albert Baertsoenkaai 3, BE-9000, Ghent.Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, RS-11221, Belgrade.Natural History Museum, Njegoševa 51, RS-11000, Belgrade.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27981797

Citation

Popović, Višnja B., et al. "Laserpitium Zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities." Chemistry & Biodiversity, vol. 14, no. 5, 2017.
Popović VB, Tomić MA, Stepanović-Petrović RM, et al. Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. Chem Biodivers. 2017;14(5).
Popović, V. B., Tomić, M. A., Stepanović-Petrović, R. M., Micov, A. M., Milenković, M. T., Petrović, S. D., Ušjak, L. J., & Niketić, M. S. (2017). Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. Chemistry & Biodiversity, 14(5). https://doi.org/10.1002/cbdv.201600432
Popović VB, et al. Laserpitium Zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. Chem Biodivers. 2017;14(5) PubMed PMID: 27981797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. AU - Popović,Višnja B, AU - Tomić,Maja A, AU - Stepanović-Petrović,Radica M, AU - Micov,Ana M, AU - Milenković,Marina T, AU - Petrović,Silvana D, AU - Ušjak,Ljuboš J, AU - Niketić,Marjan S, Y1 - 2017/04/17/ PY - 2016/11/09/received PY - 2016/12/12/accepted PY - 2016/12/17/pubmed PY - 2017/8/2/medline PY - 2016/12/17/entrez KW - Anti-edematous activities KW - Antimicrobial activities KW - Antioxidant activities KW - Laserpitium zernyi aerial parts KW - Polyphenols JF - Chemistry & biodiversity JO - Chem Biodivers VL - 14 IS - 5 N2 - Phenolic compounds and different biological activities of the dry MeOH extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides, and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract. The extracts (p.o.) were tested for anti-edematous activity in a model of carrageenan (i.pl.) induced rat paw edema. Antioxidant activity of the extracts was assessed by FRAP assay and DPPH and • OH radicals scavenging tests. Antimicrobial activity was investigated using broth microdilution test against five Gram-positive and three Gram-negative bacteria, as well as against two strains of Candida albicans. The polyphenol-richer flower extract exerted higher anti-edematous and antioxidant activities. The herb extract exhibited better antimicrobial effect against Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa, while against other tested microorganisms, the activity of both extracts was identical. Demonstrated biological activities of L. zernyi flower and herb extracts represent a good basis for their further investigation as potential new herbal medicinal raw materials. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/27981797/Laserpitium_zernyi_Hayek_Flower_and_Herb_Extracts:_Phenolic_Compounds_and_Anti_edematous_Antioxidant_and_Antimicrobial_Activities_ L2 - https://doi.org/10.1002/cbdv.201600432 DB - PRIME DP - Unbound Medicine ER -