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In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants.
Pharm Res. 1989 Jul; 6(7):612-8.PR

Abstract

The determination of the in vitro release profile of water-insoluble drug products requires dissolution media different from those used for water-soluble drug products. Since the relevance of drug dissolution in organic solvents is questionable, we investigated the use of surfactants to determine the dissolution profiles of water-insoluble drug products. In most cases, the drug dissolution rate and extent increased as the surfactant concentration in the aqueous dissolution medium increased. Suitable dissolution profiles were obtained in the presence of sodium lauryl sulfate (SLS) for water-insoluble drug products, such as griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, and cortisone acetate. These findings recommend the use of surfactants for determining the aqueous dissolution of water-insoluble drug products rather than adding organic solvents to the dissolution medium.

Authors+Show Affiliations

Shah VP
Division of Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857.
Konecny JJ
No affiliation info available
Everett RL
No affiliation info available
McCullough B
No affiliation info available
Noorizadeh AC
No affiliation info available
Skelly JP
No affiliation info available

MeSH

CapsulesCarbamazepineChemistry, PharmaceuticalClofibrateCortisoneGriseofulvinMedroxyprogesteronePharmaceutical PreparationsSolubilitySpectrophotometry, InfraredSurface-Active AgentsTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2798311

Citation

Shah, V P., et al. "In Vitro Dissolution Profile of Water-insoluble Drug Dosage Forms in the Presence of Surfactants." Pharmaceutical Research, vol. 6, no. 7, 1989, pp. 612-8.
Shah VP, Konecny JJ, Everett RL, et al. In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. Pharm Res. 1989;6(7):612-8.
Shah, V. P., Konecny, J. J., Everett, R. L., McCullough, B., Noorizadeh, A. C., & Skelly, J. P. (1989). In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. Pharmaceutical Research, 6(7), 612-8.
Shah VP, et al. In Vitro Dissolution Profile of Water-insoluble Drug Dosage Forms in the Presence of Surfactants. Pharm Res. 1989;6(7):612-8. PubMed PMID: 2798311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. AU - Shah,V P, AU - Konecny,J J, AU - Everett,R L, AU - McCullough,B, AU - Noorizadeh,A C, AU - Skelly,J P, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 612 EP - 8 JF - Pharmaceutical research JO - Pharm Res VL - 6 IS - 7 N2 - The determination of the in vitro release profile of water-insoluble drug products requires dissolution media different from those used for water-soluble drug products. Since the relevance of drug dissolution in organic solvents is questionable, we investigated the use of surfactants to determine the dissolution profiles of water-insoluble drug products. In most cases, the drug dissolution rate and extent increased as the surfactant concentration in the aqueous dissolution medium increased. Suitable dissolution profiles were obtained in the presence of sodium lauryl sulfate (SLS) for water-insoluble drug products, such as griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, and cortisone acetate. These findings recommend the use of surfactants for determining the aqueous dissolution of water-insoluble drug products rather than adding organic solvents to the dissolution medium. SN - 0724-8741 UR - https://www.unboundmedicine.com/medline/citation/2798311/In_vitro_dissolution_profile_of_water_insoluble_drug_dosage_forms_in_the_presence_of_surfactants_ DB - PRIME DP - Unbound Medicine ER -