Tags

Type your tag names separated by a space and hit enter

Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies.
Nutrients 2016; 8(12)N

Abstract

Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relation between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer. However, the association between abdominal obesity (as measured by waist circumference (WC) (BMI adjusted) and waist to hip ratio (WHR)) and lung cancer is not fully understood due to sparse available evidence regarding this association. PubMed and Web of Science databases were searched for studies assessing the association between abdominal obesity and lung cancer up to October 2016. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. Six prospective cohort studies with 5827 lung cancer cases among 831,535 participants were included in our meta-analysis. Each 10 cm increase in WC and 0.1 unit increase in WHR were associated with 10% (RR 1.10; 95% CI 1.04, 1.17; I² = 27.7%, p-heterogeneity = 0.198) and 5% (RR 1.05; 95% CI 1.00, 1.11; I² = 25.2%, p-heterogeneity = 0.211) greater risks of lung cancer, respectively. According to smoking status, greater WHR was only positively associated with lung cancer among former smokers (RR 1.11; 95% CI 1.00, 1.23). In contrast, greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I² = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I² = 24.2%, p-heterogeneity = 0.211), respectively. In summary, abdominal obesity may play an important role in the development of lung cancer.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. khemzie_khem@yahoo.com.Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. cathy-dx0630@163.com.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215123, China. lsguorong@126.com.Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China. shiminhua@163.com.Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. shibimin@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27983672

Citation

Hidayat, Khemayanto, et al. "Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies." Nutrients, vol. 8, no. 12, 2016.
Hidayat K, Du X, Chen G, et al. Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies. Nutrients. 2016;8(12).
Hidayat, K., Du, X., Chen, G., Shi, M., & Shi, B. (2016). Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies. Nutrients, 8(12).
Hidayat K, et al. Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies. Nutrients. 2016 Dec 15;8(12) PubMed PMID: 27983672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies. AU - Hidayat,Khemayanto, AU - Du,Xuan, AU - Chen,Guochong, AU - Shi,Minhua, AU - Shi,Bimin, Y1 - 2016/12/15/ PY - 2016/10/20/received PY - 2016/11/25/revised PY - 2016/12/06/accepted PY - 2016/12/17/entrez PY - 2016/12/17/pubmed PY - 2017/4/18/medline KW - abdominal obesity KW - central obesity KW - dose-response KW - lung cancer KW - waist circumference KW - waist to hip ratio JF - Nutrients JO - Nutrients VL - 8 IS - 12 N2 - Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relation between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer. However, the association between abdominal obesity (as measured by waist circumference (WC) (BMI adjusted) and waist to hip ratio (WHR)) and lung cancer is not fully understood due to sparse available evidence regarding this association. PubMed and Web of Science databases were searched for studies assessing the association between abdominal obesity and lung cancer up to October 2016. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. Six prospective cohort studies with 5827 lung cancer cases among 831,535 participants were included in our meta-analysis. Each 10 cm increase in WC and 0.1 unit increase in WHR were associated with 10% (RR 1.10; 95% CI 1.04, 1.17; I² = 27.7%, p-heterogeneity = 0.198) and 5% (RR 1.05; 95% CI 1.00, 1.11; I² = 25.2%, p-heterogeneity = 0.211) greater risks of lung cancer, respectively. According to smoking status, greater WHR was only positively associated with lung cancer among former smokers (RR 1.11; 95% CI 1.00, 1.23). In contrast, greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I² = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I² = 24.2%, p-heterogeneity = 0.211), respectively. In summary, abdominal obesity may play an important role in the development of lung cancer. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27983672/Abdominal_Obesity_and_Lung_Cancer_Risk:_Systematic_Review_and_Meta_Analysis_of_Prospective_Studies_ L2 - http://www.mdpi.com/resolver?pii=nu8120810 DB - PRIME DP - Unbound Medicine ER -