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Luteal function in patients with endometriosis.

Abstract

Nineteen patients with endometriosis were selected for investigation of luteal function as determined by serum progesterone (P) concentrations at different stages of the luteal phase, and by observation of basal body temperature (BBT) profiles and endometrial histological appearances. Sixteen cases were accompanied with infertility. All data were synchronized to the day of midcycle serum luteinizing hormone (LH) peak (D0) and analyzed accordingly. In the endometriosis group, mean serum P concentrations of early, mid luteal phases and the integrated P concentration of the whole luteal phase were significantly lower than in the control group. Five cases (26.3%) had low peak P values during mid-luteal phase and/or low integrated P levels. Delayed endometrial maturation was revealed in 10 of 16 cases (62.5%). Short luteal phase, as defined by BBT, was observed in 3 of 14 cases (21.4%). A total of 12 cases were screened for all three parameters, among them, ten (83.3%) had at least one abnormality and seven (58.3%) showed two aberrant results. In summary, the incidence of luteal phase defect was higher in the endometriosis group than in controls. The pathogenic mechanism of luteal phase defect and its role in infertility are discussed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2798407

Citation

Zhang, Y W., et al. "Luteal Function in Patients With Endometriosis." Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo I Hsueh K'o Hsueh Yuan, Chung-kuo Hsieh Ho I K'o Ta Hsueh Hsueh Pao, vol. 4, no. 2, 1989, pp. 96-101.
Zhang YW, Ji H, Han ML, et al. Luteal function in patients with endometriosis. Proc Chin Acad Med Sci Peking Union Med Coll. 1989;4(2):96-101.
Zhang, Y. W., Ji, H., Han, M. L., Tang, M. Y., Sun, A., & Zhang, D. Y. (1989). Luteal function in patients with endometriosis. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo I Hsueh K'o Hsueh Yuan, Chung-kuo Hsieh Ho I K'o Ta Hsueh Hsueh Pao, 4(2), 96-101.
Zhang YW, et al. Luteal Function in Patients With Endometriosis. Proc Chin Acad Med Sci Peking Union Med Coll. 1989;4(2):96-101. PubMed PMID: 2798407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Luteal function in patients with endometriosis. AU - Zhang,Y W, AU - Ji,H, AU - Han,M L, AU - Tang,M Y, AU - Sun,A, AU - Zhang,D Y, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 96 EP - 101 JF - Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao JO - Proc Chin Acad Med Sci Peking Union Med Coll VL - 4 IS - 2 N2 - Nineteen patients with endometriosis were selected for investigation of luteal function as determined by serum progesterone (P) concentrations at different stages of the luteal phase, and by observation of basal body temperature (BBT) profiles and endometrial histological appearances. Sixteen cases were accompanied with infertility. All data were synchronized to the day of midcycle serum luteinizing hormone (LH) peak (D0) and analyzed accordingly. In the endometriosis group, mean serum P concentrations of early, mid luteal phases and the integrated P concentration of the whole luteal phase were significantly lower than in the control group. Five cases (26.3%) had low peak P values during mid-luteal phase and/or low integrated P levels. Delayed endometrial maturation was revealed in 10 of 16 cases (62.5%). Short luteal phase, as defined by BBT, was observed in 3 of 14 cases (21.4%). A total of 12 cases were screened for all three parameters, among them, ten (83.3%) had at least one abnormality and seven (58.3%) showed two aberrant results. In summary, the incidence of luteal phase defect was higher in the endometriosis group than in controls. The pathogenic mechanism of luteal phase defect and its role in infertility are discussed. SN - 0258-8757 UR - https://www.unboundmedicine.com/medline/citation/2798407/Luteal_function_in_patients_with_endometriosis_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -