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Longitudinal trajectories of cortical thickness as a biomarker for psychosis in individuals with 22q11.2 deletion syndrome.
Schizophr Res 2017; 188:35-41SR

Abstract

OBJECTIVE

22q11.2 deletion syndrome (DS) or velo-cardio-facial syndrome (VCFS) is a genetic condition that has been identified as the highest genetic risk factor for developing psychotic illnesses. This unique biological nature of 22q11DS provides a valuable opportunity to explore predictive biomarkers of psychosis. In this study, we examined the relationship of cortical thickness and surface area between various brain regions and prodromal symptoms of psychosis.

METHODS

75 probands with 22q11DS, 32 age-matched controls and 28 siblings underwent MRIs over 2 or 3 timepoints. Longitudinal mixed model regression analyses, with age as an interaction variable, were carried out to study the differences in longitudinal trajectories of change in average cortical thickness and surface area over 6-9years. Similar analyses were carried out to examine the relationship with positive prodromal symptoms of psychosis.

RESULTS

Significant differences were noted in the inferior and superior parietal regions in both the average thickness and longitudinal change in cortical thickness with age between the probands and controls. Significant associations were also noted between regions in the frontal cortex and positive prodromal symptoms among probands. No associations were noted with cortical surface area.

CONCLUSION

Our results indicate that individuals with 22q11DS who develop positive prodromal symptoms demonstrate differential longitudinal trajectories of cortical thickness in some regions of the frontal lobe. Our results suggest that the pruning stage associated with adolescent brain development may be disrupted.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States; Hutchings Psychiatric Center, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States; Department of Computer Sciences, SUNY at Oswego, Oswego, NY 13126, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States; Department of Psychology, Syracuse University, Syracuse, NY 13210, United States.Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, United States. Electronic address: katesw@upstate.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27988073

Citation

Ramanathan, Seetha, et al. "Longitudinal Trajectories of Cortical Thickness as a Biomarker for Psychosis in Individuals With 22q11.2 Deletion Syndrome." Schizophrenia Research, vol. 188, 2017, pp. 35-41.
Ramanathan S, Mattiaccio LM, Coman IL, et al. Longitudinal trajectories of cortical thickness as a biomarker for psychosis in individuals with 22q11.2 deletion syndrome. Schizophr Res. 2017;188:35-41.
Ramanathan, S., Mattiaccio, L. M., Coman, I. L., Botti, J. C., Fremont, W., Faraone, S. V., ... Kates, W. R. (2017). Longitudinal trajectories of cortical thickness as a biomarker for psychosis in individuals with 22q11.2 deletion syndrome. Schizophrenia Research, 188, pp. 35-41. doi:10.1016/j.schres.2016.11.041.
Ramanathan S, et al. Longitudinal Trajectories of Cortical Thickness as a Biomarker for Psychosis in Individuals With 22q11.2 Deletion Syndrome. Schizophr Res. 2017;188:35-41. PubMed PMID: 27988073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal trajectories of cortical thickness as a biomarker for psychosis in individuals with 22q11.2 deletion syndrome. AU - Ramanathan,Seetha, AU - Mattiaccio,Leah M, AU - Coman,Ioana L, AU - Botti,Jo-Anna C, AU - Fremont,Wanda, AU - Faraone,Stephen V, AU - Antshel,Kevin M, AU - Kates,Wendy R, Y1 - 2016/12/15/ PY - 2016/07/10/received PY - 2016/11/25/revised PY - 2016/11/25/accepted PY - 2016/12/19/pubmed PY - 2018/5/31/medline PY - 2016/12/19/entrez KW - 22q11DS KW - Cortical morphology KW - Psychosis KW - Schizophrenia KW - Velo-cardio-facial syndrome SP - 35 EP - 41 JF - Schizophrenia research JO - Schizophr. Res. VL - 188 N2 - OBJECTIVE: 22q11.2 deletion syndrome (DS) or velo-cardio-facial syndrome (VCFS) is a genetic condition that has been identified as the highest genetic risk factor for developing psychotic illnesses. This unique biological nature of 22q11DS provides a valuable opportunity to explore predictive biomarkers of psychosis. In this study, we examined the relationship of cortical thickness and surface area between various brain regions and prodromal symptoms of psychosis. METHODS: 75 probands with 22q11DS, 32 age-matched controls and 28 siblings underwent MRIs over 2 or 3 timepoints. Longitudinal mixed model regression analyses, with age as an interaction variable, were carried out to study the differences in longitudinal trajectories of change in average cortical thickness and surface area over 6-9years. Similar analyses were carried out to examine the relationship with positive prodromal symptoms of psychosis. RESULTS: Significant differences were noted in the inferior and superior parietal regions in both the average thickness and longitudinal change in cortical thickness with age between the probands and controls. Significant associations were also noted between regions in the frontal cortex and positive prodromal symptoms among probands. No associations were noted with cortical surface area. CONCLUSION: Our results indicate that individuals with 22q11DS who develop positive prodromal symptoms demonstrate differential longitudinal trajectories of cortical thickness in some regions of the frontal lobe. Our results suggest that the pruning stage associated with adolescent brain development may be disrupted. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/27988073/Longitudinal_trajectories_of_cortical_thickness_as_a_biomarker_for_psychosis_in_individuals_with_22q11_2_deletion_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(16)30551-5 DB - PRIME DP - Unbound Medicine ER -