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Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system.
Eur J Pharmacol. 2017 Feb 05; 796:32-38.EJ

Abstract

Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties of cardamonin, a naturally occurring chalcone in chronic constriction injury (CCI)-induced neuropathic pain mice model. Our findings showed that single and repeated dose of intra-peritoneal administration of cardamonin (3, 10, 30mg/kg) significantly inhibited (P<0.001) the chronic constriction injury-induced neuropathic pain using the Hargreaves plantar test, Randall-Selitto analgesiometer test, dynamic plantar anesthesiometer test and the cold plate test in comparison with the positive control drug used (amitriptyline hydrochloride, 20mg/kg, i.p.). Pre-treatment with naloxone hydrochloride (1mg/kg, i.p.) and naloxone methiodide (1mg/kg, s.c) significantly reversed the antiallodynic and antihyperalgesic effects of cardamonin in dynamic plantar anesthesiometer test and Hargreaves plantar test, respectively. In conclusion, the current findings demonstrated novel antiallodynic and antihyperalgesic effects of cardamonin through the activation of the opioidergic system both peripherally and centrally and may prove to be a potent lead compound for the development of neuropathic pain drugs in the future.

Authors+Show Affiliations

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.Biomedical Science Programme, School of Diagnostic and Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. Electronic address: enoch@upm.edu.my.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27988285

Citation

Sambasevam, Yogesvari, et al. "Cardamonin Attenuates Hyperalgesia and Allodynia in a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Possible Involvement of the Opioid System." European Journal of Pharmacology, vol. 796, 2017, pp. 32-38.
Sambasevam Y, Omar Farouk AA, Tengku Mohamad TA, et al. Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system. Eur J Pharmacol. 2017;796:32-38.
Sambasevam, Y., Omar Farouk, A. A., Tengku Mohamad, T. A., Sulaiman, M. R., Bharatham, B. H., & Perimal, E. K. (2017). Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system. European Journal of Pharmacology, 796, 32-38. https://doi.org/10.1016/j.ejphar.2016.12.020
Sambasevam Y, et al. Cardamonin Attenuates Hyperalgesia and Allodynia in a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Possible Involvement of the Opioid System. Eur J Pharmacol. 2017 Feb 5;796:32-38. PubMed PMID: 27988285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system. AU - Sambasevam,Yogesvari, AU - Omar Farouk,Ahmad Akira, AU - Tengku Mohamad,Tengku Azam Shah, AU - Sulaiman,Mohd Roslan, AU - Bharatham,B Hemabarathy, AU - Perimal,Enoch Kumar, Y1 - 2016/12/15/ PY - 2016/11/11/received PY - 2016/12/14/revised PY - 2016/12/14/accepted PY - 2016/12/19/pubmed PY - 2017/4/30/medline PY - 2016/12/19/entrez KW - Allodynia KW - Amitriptyline hydrochloride (PubChem CID: 11065), Tribromoethanol (PubChem CID: 6400) KW - CCI KW - Cardamonin KW - Cardamonin (PubChem CID: 10424762) KW - Dimethyl sulphoxide (PubChem CID: 679) KW - Hyperalgesia KW - Iodine (PubChem CID: 410087) KW - Morphine sulphate (PubChem CID: 6321225) KW - Naloxone hydrochloride (PubChem CID: 5464092) KW - Naloxone methiodide (PubChem CID: 16219719) KW - Neuropathic pain SP - 32 EP - 38 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 796 N2 - Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties of cardamonin, a naturally occurring chalcone in chronic constriction injury (CCI)-induced neuropathic pain mice model. Our findings showed that single and repeated dose of intra-peritoneal administration of cardamonin (3, 10, 30mg/kg) significantly inhibited (P<0.001) the chronic constriction injury-induced neuropathic pain using the Hargreaves plantar test, Randall-Selitto analgesiometer test, dynamic plantar anesthesiometer test and the cold plate test in comparison with the positive control drug used (amitriptyline hydrochloride, 20mg/kg, i.p.). Pre-treatment with naloxone hydrochloride (1mg/kg, i.p.) and naloxone methiodide (1mg/kg, s.c) significantly reversed the antiallodynic and antihyperalgesic effects of cardamonin in dynamic plantar anesthesiometer test and Hargreaves plantar test, respectively. In conclusion, the current findings demonstrated novel antiallodynic and antihyperalgesic effects of cardamonin through the activation of the opioidergic system both peripherally and centrally and may prove to be a potent lead compound for the development of neuropathic pain drugs in the future. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/27988285/Cardamonin_attenuates_hyperalgesia_and_allodynia_in_a_mouse_model_of_chronic_constriction_injury_induced_neuropathic_pain:_Possible_involvement_of_the_opioid_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(16)30791-9 DB - PRIME DP - Unbound Medicine ER -