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Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan.
Vaccine. 2017 01 11; 35(3):435-442.V

Abstract

By September 2013, war between Sudan and South Sudan resulted in >70,000 Sudanese refugees and high pneumonia incidence among the 20,000 refugees in Yida camp, South Sudan. Using Médecins Sans Frontières (MSF)-provided data and modifying our decision-tree models, we estimated if administering Haemophilus influenzae type b (Hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [DPT] and hepatitis B) and pneumococcal conjugate (PCV) vaccines were cost-effective against hospitalized pneumonia. Among children <2years old, compared with no vaccination, one- and two-doses of combined Hib-containing and PCV would avert an estimated 118 and 125 pneumonia cases, and 8.5 and 9.1 deaths, respectively. The cost per Disability-Adjusted-Life-Year averted for administering combined one- and two-doses was US$125 and US$209, respectively. MSF demonstrated that it was possible to administer these vaccines during an emergency and our analysis found it was highly cost-effective, even with just one-dose of either vaccine. Despite unknown etiology, there is strong field and now economic rationale for administering Hib and PCV during at least one humanitarian emergency.

Authors+Show Affiliations

Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States.Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: sgc0@cdc.gov.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27989625

Citation

Gargano, Lisa M., et al. "Pneumonia Prevention: Cost-effectiveness Analyses of Two Vaccines Among Refugee Children Aged Under Two Years, Haemophilus Influenzae Type B-containing and Pneumococcal Conjugate Vaccines, During a Humanitarian Emergency, Yida Camp, South Sudan." Vaccine, vol. 35, no. 3, 2017, pp. 435-442.
Gargano LM, Hajjeh R, Cookson ST. Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan. Vaccine. 2017;35(3):435-442.
Gargano, L. M., Hajjeh, R., & Cookson, S. T. (2017). Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan. Vaccine, 35(3), 435-442. https://doi.org/10.1016/j.vaccine.2016.11.070
Gargano LM, Hajjeh R, Cookson ST. Pneumonia Prevention: Cost-effectiveness Analyses of Two Vaccines Among Refugee Children Aged Under Two Years, Haemophilus Influenzae Type B-containing and Pneumococcal Conjugate Vaccines, During a Humanitarian Emergency, Yida Camp, South Sudan. Vaccine. 2017 01 11;35(3):435-442. PubMed PMID: 27989625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan. AU - Gargano,Lisa M, AU - Hajjeh,Rana, AU - Cookson,Susan T, Y1 - 2016/12/15/ PY - 2016/02/22/received PY - 2016/11/18/revised PY - 2016/11/21/accepted PY - 2016/12/19/pubmed PY - 2017/12/20/medline PY - 2016/12/20/entrez KW - Cost-effectiveness KW - Haemophilus influenzae type b KW - Hib vaccine KW - Humanitarian emergency KW - PCV KW - Routine immunization KW - South Sudan KW - Streptococcus pneumoniae KW - Supplemental immunization activity SP - 435 EP - 442 JF - Vaccine JO - Vaccine VL - 35 IS - 3 N2 - By September 2013, war between Sudan and South Sudan resulted in >70,000 Sudanese refugees and high pneumonia incidence among the 20,000 refugees in Yida camp, South Sudan. Using Médecins Sans Frontières (MSF)-provided data and modifying our decision-tree models, we estimated if administering Haemophilus influenzae type b (Hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [DPT] and hepatitis B) and pneumococcal conjugate (PCV) vaccines were cost-effective against hospitalized pneumonia. Among children <2years old, compared with no vaccination, one- and two-doses of combined Hib-containing and PCV would avert an estimated 118 and 125 pneumonia cases, and 8.5 and 9.1 deaths, respectively. The cost per Disability-Adjusted-Life-Year averted for administering combined one- and two-doses was US$125 and US$209, respectively. MSF demonstrated that it was possible to administer these vaccines during an emergency and our analysis found it was highly cost-effective, even with just one-dose of either vaccine. Despite unknown etiology, there is strong field and now economic rationale for administering Hib and PCV during at least one humanitarian emergency. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/27989625/Pneumonia_prevention:_Cost_effectiveness_analyses_of_two_vaccines_among_refugee_children_aged_under_two_years_Haemophilus_influenzae_type_b_containing_and_pneumococcal_conjugate_vaccines_during_a_humanitarian_emergency_Yida_camp_South_Sudan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(16)31141-0 DB - PRIME DP - Unbound Medicine ER -