Tags

Type your tag names separated by a space and hit enter

Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain.
J Antimicrob Chemother. 2017 03 01; 72(3):754-761.JA

Abstract

Objectives

The aims of this study were to explore the clinical distribution, by species, of the genus Nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in Spain.

Methods

Over a 10 year period (2005-14), 1119 Nocardia strains were molecularly identified and subjected to the Etest. The distribution and resistance trends over the sub-periods 2005-09 and 2010-14 were also examined.

Results

Of the strains examined, 82.9% belonged to the following species: Nocardia cyriacigeorgica (25.3%), Nocardia nova (15.0%), Nocardia abscessus (12.7%), Nocardia farcinica (11.4%), Nocardia carnea (4.3%), Nocardia brasiliensis (3.5%), Nocardia otitidiscaviarum (3.1%), Nocardia flavorosea (2.6%), Nocardia rhamnosiphila (2.6%) and Nocardia transvalensis (2.4%). Their prevalence values were similar during 2005-09 and 2010-14, except for those of N. abscessus , N. farcinica and N. transvalensis , which fell significantly in the second sub-period (P ≤ 0.05). The major location of isolation was the respiratory tract (∼86%). Half (13/27) of all strains from the CNS were N. farcinica . Significant differences in MIC results were recorded for some species between the two sub-periods. According to the CLSI's breakpoints, low resistance rates (≤15%) were recorded for seven species with respect to cefotaxime, imipenem and tobramycin; five species showed similar rates with respect to trimethoprim/sulfamethoxazole. Linezolid and amikacin were the most frequently active agents.

Conclusion

The accurate identification of the infecting species and the determination of its susceptibility to antimicrobial agents, given the large number of strains with atypical patterns, are crucial if patients with nocardiosis are to be successfully treated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27999029

Citation

Valdezate, Sylvia, et al. "Epidemiology and Susceptibility to Antimicrobial Agents of the Main Nocardia Species in Spain." The Journal of Antimicrobial Chemotherapy, vol. 72, no. 3, 2017, pp. 754-761.
Valdezate S, Garrido N, Carrasco G, et al. Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. J Antimicrob Chemother. 2017;72(3):754-761.
Valdezate, S., Garrido, N., Carrasco, G., Medina-Pascual, M. J., Villalón, P., Navarro, A. M., & Saéz-Nieto, J. A. (2017). Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. The Journal of Antimicrobial Chemotherapy, 72(3), 754-761. https://doi.org/10.1093/jac/dkw489
Valdezate S, et al. Epidemiology and Susceptibility to Antimicrobial Agents of the Main Nocardia Species in Spain. J Antimicrob Chemother. 2017 03 1;72(3):754-761. PubMed PMID: 27999029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. AU - Valdezate,Sylvia, AU - Garrido,Noelia, AU - Carrasco,Gema, AU - Medina-Pascual,María J, AU - Villalón,Pilar, AU - Navarro,Ana M, AU - Saéz-Nieto,Juan A, PY - 2016/05/17/received PY - 2016/10/12/accepted PY - 2016/12/22/pubmed PY - 2017/10/11/medline PY - 2016/12/22/entrez SP - 754 EP - 761 JF - The Journal of antimicrobial chemotherapy JO - J. Antimicrob. Chemother. VL - 72 IS - 3 N2 - Objectives: The aims of this study were to explore the clinical distribution, by species, of the genus Nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in Spain. Methods: Over a 10 year period (2005-14), 1119 Nocardia strains were molecularly identified and subjected to the Etest. The distribution and resistance trends over the sub-periods 2005-09 and 2010-14 were also examined. Results: Of the strains examined, 82.9% belonged to the following species: Nocardia cyriacigeorgica (25.3%), Nocardia nova (15.0%), Nocardia abscessus (12.7%), Nocardia farcinica (11.4%), Nocardia carnea (4.3%), Nocardia brasiliensis (3.5%), Nocardia otitidiscaviarum (3.1%), Nocardia flavorosea (2.6%), Nocardia rhamnosiphila (2.6%) and Nocardia transvalensis (2.4%). Their prevalence values were similar during 2005-09 and 2010-14, except for those of N. abscessus , N. farcinica and N. transvalensis , which fell significantly in the second sub-period (P ≤ 0.05). The major location of isolation was the respiratory tract (∼86%). Half (13/27) of all strains from the CNS were N. farcinica . Significant differences in MIC results were recorded for some species between the two sub-periods. According to the CLSI's breakpoints, low resistance rates (≤15%) were recorded for seven species with respect to cefotaxime, imipenem and tobramycin; five species showed similar rates with respect to trimethoprim/sulfamethoxazole. Linezolid and amikacin were the most frequently active agents. Conclusion: The accurate identification of the infecting species and the determination of its susceptibility to antimicrobial agents, given the large number of strains with atypical patterns, are crucial if patients with nocardiosis are to be successfully treated. SN - 1460-2091 UR - https://www.unboundmedicine.com/medline/citation/27999029/Epidemiology_and_susceptibility_to_antimicrobial_agents_of_the_main_Nocardia_species_in_Spain_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkw489 DB - PRIME DP - Unbound Medicine ER -