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Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum.
Mar Drugs. 2016 Dec 20; 14(12)MD

Abstract

Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound 6 inhibited the growth of LNCaP cells by inducing apoptosis.

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Authors+Show Affiliations

Zhang Z
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zhihanzhang1992@163.com.
Min X
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. mixmix@stu.scau.edu.cn.
Huang J
Pharmaceutical Research Center, School of Pharmacology, Guangzhou Medical University, Guangzhou 510182, China. huangjunjun1985@sina.com.
Zhong Y
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. sloe96824400@126.com.
Wu Y
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. wuyuehua_10@163.com.
Li X
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. m18320728922@163.com.
Deng Y
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn. Guangdong Innovative and Entrepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn.
Jiang Z
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zdjiang@scau.edu.cn.
Shao Z
State Key Laboratory Breeding Base of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, Key Laboratory of Marine Genetic Resources of Fujian Province, Xiamen 361005, China. shaozz@163.com.
Zhang L
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. lhzhang01@scau.edu.cn.
He F
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. hefei@scsio.ac.cn.

MeSH

AnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationChaetomiumChromatography, High Pressure LiquidDrug Screening Assays, AntitumorFermentationHumansIndole AlkaloidsMagnetic Resonance SpectroscopyMass SpectrometryMiceSolid Phase Extraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27999388

Citation

Zhang, Zhihan, et al. "Cytoglobosins H and I, New Antiproliferative Cytochalasans From Deep-Sea-Derived Fungus Chaetomium Globosum." Marine Drugs, vol. 14, no. 12, 2016.
Zhang Z, Min X, Huang J, et al. Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum. Mar Drugs. 2016;14(12).
Zhang, Z., Min, X., Huang, J., Zhong, Y., Wu, Y., Li, X., Deng, Y., Jiang, Z., Shao, Z., Zhang, L., & He, F. (2016). Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum. Marine Drugs, 14(12). https://doi.org/10.3390/md14120233
Zhang Z, et al. Cytoglobosins H and I, New Antiproliferative Cytochalasans From Deep-Sea-Derived Fungus Chaetomium Globosum. Mar Drugs. 2016 Dec 20;14(12) PubMed PMID: 27999388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum. AU - Zhang,Zhihan, AU - Min,Xitian, AU - Huang,Junjun, AU - Zhong,Yue, AU - Wu,Yuehua, AU - Li,Xiaoxia, AU - Deng,Yinyue, AU - Jiang,Zide, AU - Shao,Zongze, AU - Zhang,Lianhui, AU - He,Fei, Y1 - 2016/12/20/ PY - 2016/11/04/received PY - 2016/12/13/revised PY - 2016/12/14/accepted PY - 2016/12/22/entrez PY - 2016/12/22/pubmed PY - 2017/5/4/medline KW - antiproliferative activity KW - cytochalasans KW - fungus JF - Marine drugs JO - Mar Drugs VL - 14 IS - 12 N2 - Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound 6 inhibited the growth of LNCaP cells by inducing apoptosis. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/27999388/Cytoglobosins_H_and_I_New_Antiproliferative_Cytochalasans_from_Deep_Sea_Derived_Fungus_Chaetomium_globosum_ DB - PRIME DP - Unbound Medicine ER -