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The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis.
J Clin Rheumatol. 2017 Jan; 23(1):33-39.JC

Abstract

OBJECTIVE

The aims of this study were to compare the levels of 25-hydroxyvitamin D (25(OH)D) in patients with early-onset rheumatoid arthritis (EORA) versus a healthy control group and to assess the association of 25(OH)D deficiency and the BsmI polymorphism of the vitamin D receptor gene with clinical, radiological, and laboratory parameters.

METHODS

Early-onset RA Colombian patients were enrolled in a 3-year follow-up study. Vitamin D deficiency was diagnosed for 25(OH)D levels of less than 20 ng/mL. Pearson and Spearman correlation coefficients were used to assess data.

RESULTS

Seventy patients and 70 matched healthy subjects were included. 25-Hydroxyvitamin D was lower in the EORA group (27.13 [SD, 13.4] ng/mL vs. 33.74 [SD, 16.7] ng/mL; P = 0.01); 31.4% of EORA patients were vitamin D deficient. Remission was higher in subjects without 25(OH)D deficiency (22.7% vs. 47.9%; P = 0.04). Patients with 25(OH)D deficiency at baseline had higher Health Assessment Questionnaire and Physician Global Disease Activity Assessment scores, fatigue levels, erythrocyte sedimentation rate, and morning stiffness after 3 years. At disease onset, only a relationship between 25(OH)D deficiency with fatigue and morning stiffness was found. Neither radiographic progression nor Sharp van der-Heidje score was associated to hypovitaminosis D after 36-month follow-up. The bb genotype was less frequent in patients with vitamin D deficiency (0% vs. 16.6%; P = 0.04). Patients with BB-Bb genotype had lower 25(OH)D and a propensity to more severe disease.

CONCLUSIONS

Our data provide further support for a role of vitamin D as a clinical biomarker for RA. Baseline 25(OH)D could have potential as a predictor of disease severity in EORA.

Authors+Show Affiliations

From the *Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira; and †Genetics Institute, ‡Faculty of Medicine, §Radiology Unit, ∥Pathology Unit, Genetic Institute, and ¶Rheumatology Unit, Faculty of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28002154

Citation

Quintana-Duque, Mario Andrés, et al. "The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis." Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases, vol. 23, no. 1, 2017, pp. 33-39.
Quintana-Duque MA, Caminos JE, Varela-Nariño A, et al. The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis. J Clin Rheumatol. 2017;23(1):33-39.
Quintana-Duque, M. A., Caminos, J. E., Varela-Nariño, A., Calvo-Paramo, E., Yunis, J. J., & Iglesias-Gamarra, A. (2017). The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis. Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases, 23(1), 33-39. https://doi.org/10.1097/RHU.0000000000000477
Quintana-Duque MA, et al. The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis. J Clin Rheumatol. 2017;23(1):33-39. PubMed PMID: 28002154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of 25-Hydroxyvitamin D as a Predictor of Clinical and Radiological Outcomes in Early Onset Rheumatoid Arthritis. AU - Quintana-Duque,Mario Andrés, AU - Caminos,Jorge Eduardo, AU - Varela-Nariño,Adriana, AU - Calvo-Paramo,Enrique, AU - Yunis,Juan José, AU - Iglesias-Gamarra,Antonio, PY - 2016/12/22/entrez PY - 2016/12/22/pubmed PY - 2017/7/25/medline SP - 33 EP - 39 JF - Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases JO - J Clin Rheumatol VL - 23 IS - 1 N2 - OBJECTIVE: The aims of this study were to compare the levels of 25-hydroxyvitamin D (25(OH)D) in patients with early-onset rheumatoid arthritis (EORA) versus a healthy control group and to assess the association of 25(OH)D deficiency and the BsmI polymorphism of the vitamin D receptor gene with clinical, radiological, and laboratory parameters. METHODS: Early-onset RA Colombian patients were enrolled in a 3-year follow-up study. Vitamin D deficiency was diagnosed for 25(OH)D levels of less than 20 ng/mL. Pearson and Spearman correlation coefficients were used to assess data. RESULTS: Seventy patients and 70 matched healthy subjects were included. 25-Hydroxyvitamin D was lower in the EORA group (27.13 [SD, 13.4] ng/mL vs. 33.74 [SD, 16.7] ng/mL; P = 0.01); 31.4% of EORA patients were vitamin D deficient. Remission was higher in subjects without 25(OH)D deficiency (22.7% vs. 47.9%; P = 0.04). Patients with 25(OH)D deficiency at baseline had higher Health Assessment Questionnaire and Physician Global Disease Activity Assessment scores, fatigue levels, erythrocyte sedimentation rate, and morning stiffness after 3 years. At disease onset, only a relationship between 25(OH)D deficiency with fatigue and morning stiffness was found. Neither radiographic progression nor Sharp van der-Heidje score was associated to hypovitaminosis D after 36-month follow-up. The bb genotype was less frequent in patients with vitamin D deficiency (0% vs. 16.6%; P = 0.04). Patients with BB-Bb genotype had lower 25(OH)D and a propensity to more severe disease. CONCLUSIONS: Our data provide further support for a role of vitamin D as a clinical biomarker for RA. Baseline 25(OH)D could have potential as a predictor of disease severity in EORA. SN - 1536-7355 UR - https://www.unboundmedicine.com/medline/citation/28002154/The_Role_of_25_Hydroxyvitamin_D_as_a_Predictor_of_Clinical_and_Radiological_Outcomes_in_Early_Onset_Rheumatoid_Arthritis_ DB - PRIME DP - Unbound Medicine ER -