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Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women.
J Nutrigenet Nutrigenomics. 2016; 9(5-6):231-242.JN

Abstract

BACKGROUND

The aims of this study were: (1) to evaluate the association of serum osteocalcin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal and elderly Chinese women, and (2) to observe the relationships of single-nucleotide polymorphisms (SNPs) in and around the osteocalcin gene with osteocalcin and BMD.

METHODS

A cross-sectional study was conducted with 725 postmenopausal Chinese women. Five SNPs (rs1543294, rs1800247, rs759330, rs2842880, and rs933489) of the osteocalcin gene were genotyped. Serum osteocalcin and intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], and type I collagen containing cross-linked C-telopeptide (β-CTX) were measured. The BMD of the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry.

RESULTS

Osteocalcin was positively correlated with serum phosphorus (p = 0.001), alkaline phosphatase (ALP; p < 0.001), PTH (p = 0.002) and β-CTX (p < 0.001), and negatively correlated with BMD at the lumbar spine (p < 0.001) and total hip (p = 0.002). No significant association was obtained between the SNPs, haplotypes of the osteocalcin gene, and BMD or osteocalcin.

CONCLUSION

Our results suggest that osteocalcin was positively correlated with serum phosphorus, ALP, PTH, and β-CTX, but negatively correlated with BMD at the lumbar spine and total hip. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women.

Authors+Show Affiliations

Metabolic Bone Disease and Genetic Research Unit, Division of Osteoporosis and Bone Disease, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28002816

Citation

Zhang, Xiao-Ya, et al. "Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene With Bone Mineral Density in Postmenopausal and Elderly Chinese Women." Journal of Nutrigenetics and Nutrigenomics, vol. 9, no. 5-6, 2016, pp. 231-242.
Zhang XY, He JW, Fu WZ, et al. Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women. J Nutrigenet Nutrigenomics. 2016;9(5-6):231-242.
Zhang, X. Y., He, J. W., Fu, W. Z., Liu, Y. J., & Zhang, Z. L. (2016). Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women. Journal of Nutrigenetics and Nutrigenomics, 9(5-6), 231-242. https://doi.org/10.1159/000452130
Zhang XY, et al. Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene With Bone Mineral Density in Postmenopausal and Elderly Chinese Women. J Nutrigenet Nutrigenomics. 2016;9(5-6):231-242. PubMed PMID: 28002816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women. AU - Zhang,Xiao-Ya, AU - He,Jin-Wei, AU - Fu,Wen-Zhen, AU - Liu,Yu-Juan, AU - Zhang,Zhen-Lin, Y1 - 2016/12/22/ PY - 2016/03/23/received PY - 2016/09/29/accepted PY - 2016/12/22/pubmed PY - 2017/11/29/medline PY - 2016/12/22/entrez SP - 231 EP - 242 JF - Journal of nutrigenetics and nutrigenomics JO - J Nutrigenet Nutrigenomics VL - 9 IS - 5-6 N2 - BACKGROUND: The aims of this study were: (1) to evaluate the association of serum osteocalcin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal and elderly Chinese women, and (2) to observe the relationships of single-nucleotide polymorphisms (SNPs) in and around the osteocalcin gene with osteocalcin and BMD. METHODS: A cross-sectional study was conducted with 725 postmenopausal Chinese women. Five SNPs (rs1543294, rs1800247, rs759330, rs2842880, and rs933489) of the osteocalcin gene were genotyped. Serum osteocalcin and intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], and type I collagen containing cross-linked C-telopeptide (β-CTX) were measured. The BMD of the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry. RESULTS: Osteocalcin was positively correlated with serum phosphorus (p = 0.001), alkaline phosphatase (ALP; p < 0.001), PTH (p = 0.002) and β-CTX (p < 0.001), and negatively correlated with BMD at the lumbar spine (p < 0.001) and total hip (p = 0.002). No significant association was obtained between the SNPs, haplotypes of the osteocalcin gene, and BMD or osteocalcin. CONCLUSION: Our results suggest that osteocalcin was positively correlated with serum phosphorus, ALP, PTH, and β-CTX, but negatively correlated with BMD at the lumbar spine and total hip. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women. SN - 1661-6758 UR - https://www.unboundmedicine.com/medline/citation/28002816/Associations_of_Serum_Osteocalcin_and_Polymorphisms_of_the_Osteocalcin_Gene_with_Bone_Mineral_Density_in_Postmenopausal_and_Elderly_Chinese_Women_ L2 - https://www.karger.com?DOI=10.1159/000452130 DB - PRIME DP - Unbound Medicine ER -