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Fasting plasma glucose variability and all-cause mortality among type 2 diabetes patients: a dynamic cohort study in Shanghai, China.
Sci Rep. 2016 12 22; 6:39633.SR

Abstract

The study aims to examine whether the variation of fasting plasma glucose (FPG), represented by coefficient of variation (CV), independently predicts all-cause mortality among Chinese type 2 diabetes patients. This retrospective cohort study was designed based on a standardized electronic management system of diabetes patients in Shanghai, China. 8871 type 2 diabetes patients were enrolled between 1 January 2007 and 31 December 2007 and were followed-up for all-cause mortality until 31 December 2014. All patients were grouped by the quartiles of CV of FPG. 1136 patients deceased during following-up. After adjusting for other risk factors, CV of FPG was not independently associated with all-cause mortality. Stratified analysis by mean FPG levels (<7 mmol/L and ≥7 mmol/L) observed a significant modifying effect of CV of FPG (P for interact test <0.01). CV of FPG was independently associated with all-cause mortality in patients whose glucose control was poor, with the HRs (95% CI) for the second, third, fourth vs first quartiles of CV of FPG being 1.23(0.94-1.61), 1.23(0.94-1.61), and 1.63(1.25-2.13), respectively. Our results suggest that variability of FPG may be an important predictor of mortality among type 2 diabetes in China, particularly for those with their glycemic status uncontrolled.

Authors+Show Affiliations

Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education (Fudan University), Shanghai, China.Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28004765

Citation

Xu, Dongli, et al. "Fasting Plasma Glucose Variability and All-cause Mortality Among Type 2 Diabetes Patients: a Dynamic Cohort Study in Shanghai, China." Scientific Reports, vol. 6, 2016, p. 39633.
Xu D, Fang H, Xu W, et al. Fasting plasma glucose variability and all-cause mortality among type 2 diabetes patients: a dynamic cohort study in Shanghai, China. Sci Rep. 2016;6:39633.
Xu, D., Fang, H., Xu, W., Yan, Y., Liu, Y., & Yao, B. (2016). Fasting plasma glucose variability and all-cause mortality among type 2 diabetes patients: a dynamic cohort study in Shanghai, China. Scientific Reports, 6, 39633. https://doi.org/10.1038/srep39633
Xu D, et al. Fasting Plasma Glucose Variability and All-cause Mortality Among Type 2 Diabetes Patients: a Dynamic Cohort Study in Shanghai, China. Sci Rep. 2016 12 22;6:39633. PubMed PMID: 28004765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting plasma glucose variability and all-cause mortality among type 2 diabetes patients: a dynamic cohort study in Shanghai, China. AU - Xu,Dongli, AU - Fang,Hong, AU - Xu,Wanghong, AU - Yan,Yujie, AU - Liu,Yinan, AU - Yao,Baodong, Y1 - 2016/12/22/ PY - 2016/06/06/received PY - 2016/11/25/accepted PY - 2016/12/23/entrez PY - 2016/12/23/pubmed PY - 2018/7/14/medline SP - 39633 EP - 39633 JF - Scientific reports JO - Sci Rep VL - 6 N2 - The study aims to examine whether the variation of fasting plasma glucose (FPG), represented by coefficient of variation (CV), independently predicts all-cause mortality among Chinese type 2 diabetes patients. This retrospective cohort study was designed based on a standardized electronic management system of diabetes patients in Shanghai, China. 8871 type 2 diabetes patients were enrolled between 1 January 2007 and 31 December 2007 and were followed-up for all-cause mortality until 31 December 2014. All patients were grouped by the quartiles of CV of FPG. 1136 patients deceased during following-up. After adjusting for other risk factors, CV of FPG was not independently associated with all-cause mortality. Stratified analysis by mean FPG levels (<7 mmol/L and ≥7 mmol/L) observed a significant modifying effect of CV of FPG (P for interact test <0.01). CV of FPG was independently associated with all-cause mortality in patients whose glucose control was poor, with the HRs (95% CI) for the second, third, fourth vs first quartiles of CV of FPG being 1.23(0.94-1.61), 1.23(0.94-1.61), and 1.63(1.25-2.13), respectively. Our results suggest that variability of FPG may be an important predictor of mortality among type 2 diabetes in China, particularly for those with their glycemic status uncontrolled. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28004765/Fasting_plasma_glucose_variability_and_all_cause_mortality_among_type_2_diabetes_patients:_a_dynamic_cohort_study_in_Shanghai_China_ L2 - https://doi.org/10.1038/srep39633 DB - PRIME DP - Unbound Medicine ER -