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Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta.
Mov Disord. 2017 03; 32(3):441-449.MD

Abstract

BACKGROUND

In PD, at the time of diagnosis, approximately 50% of melanized dopaminergic neurons in SNpc have died, yet ongoing neuronal death and neuromelanin release with associated neuroinflammation and microglial activation continue, as does local iron accumulation. Previous studies investigating nigral iron accumulation used T2 / T2*-weighted contrasts to define the regions of interest in the SN. Given that T2 / T2*-weighted contrasts lack sensitivity to neuromelanin and thereby SNpc, neuromelanin-sensitive MRI provides better delineation of SNpc and allows the examination of increased iron deposition in SNpc more specifically and accurately.

OBJECTIVES

To examine regions of the SNpc, defined by neuromelanin-sensitive MRI, exhibiting iron deposition in PD.

METHODS

T1 -weighted and susceptibility weighted imaging data were obtained in a cohort of 82 subjects (54 controls and 28 PD patients). The PD patients were clinically diagnosed with an average UPDRS-III score of 37.9 ± 12.5 in the off medication state. Susceptibility weighted imaging data were analyzed using SNpc regions of interest defined by neuromelanin-sensitive MRI.

RESULTS

Compared to control subjects, significantly more hypointense signal was observed in the SNpc defined by neuromelanin-sensitive MRI in the PD patients. In the PD group, the lateral ventral region of SNpc exhibited the greatest increase of hypointensity. This increase in the lateral ventral region of SNpc robustly differentiated PD patients from controls.

CONCLUSION

T2*-weighted hypointense signal in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD. It is most likely a measure sensitive to PD-related iron deposition and may serve as a robust biomarker of PD. © 2016 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA. Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA.Department of Neurology, Emory University, Atlanta, Georgia, USA.Department of Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.Department of Neurology, Julius-Maximilians-University, Würzburg, Germany.Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA. Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA. Department of Bioengineering, University of California Riverside, Riverside, California, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28004859

Citation

Langley, Jason, et al. "Parkinson's Disease-related Increase of T2*-weighted Hypointensity in Substantia Nigra Pars Compacta." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 32, no. 3, 2017, pp. 441-449.
Langley J, Huddleston DE, Sedlacik J, et al. Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta. Mov Disord. 2017;32(3):441-449.
Langley, J., Huddleston, D. E., Sedlacik, J., Boelmans, K., & Hu, X. P. (2017). Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta. Movement Disorders : Official Journal of the Movement Disorder Society, 32(3), 441-449. https://doi.org/10.1002/mds.26883
Langley J, et al. Parkinson's Disease-related Increase of T2*-weighted Hypointensity in Substantia Nigra Pars Compacta. Mov Disord. 2017;32(3):441-449. PubMed PMID: 28004859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta. AU - Langley,Jason, AU - Huddleston,Daniel E, AU - Sedlacik,Jan, AU - Boelmans,Kai, AU - Hu,Xiaoping P, Y1 - 2016/12/22/ PY - 2016/05/17/received PY - 2016/10/03/revised PY - 2016/10/23/accepted PY - 2016/12/23/pubmed PY - 2017/12/30/medline PY - 2016/12/23/entrez KW - MRI KW - Parkinson's disease KW - neuromelanin KW - substantia nigra pars compacta KW - susceptibility weighted imaging SP - 441 EP - 449 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 32 IS - 3 N2 - BACKGROUND: In PD, at the time of diagnosis, approximately 50% of melanized dopaminergic neurons in SNpc have died, yet ongoing neuronal death and neuromelanin release with associated neuroinflammation and microglial activation continue, as does local iron accumulation. Previous studies investigating nigral iron accumulation used T2 / T2*-weighted contrasts to define the regions of interest in the SN. Given that T2 / T2*-weighted contrasts lack sensitivity to neuromelanin and thereby SNpc, neuromelanin-sensitive MRI provides better delineation of SNpc and allows the examination of increased iron deposition in SNpc more specifically and accurately. OBJECTIVES: To examine regions of the SNpc, defined by neuromelanin-sensitive MRI, exhibiting iron deposition in PD. METHODS: T1 -weighted and susceptibility weighted imaging data were obtained in a cohort of 82 subjects (54 controls and 28 PD patients). The PD patients were clinically diagnosed with an average UPDRS-III score of 37.9 ± 12.5 in the off medication state. Susceptibility weighted imaging data were analyzed using SNpc regions of interest defined by neuromelanin-sensitive MRI. RESULTS: Compared to control subjects, significantly more hypointense signal was observed in the SNpc defined by neuromelanin-sensitive MRI in the PD patients. In the PD group, the lateral ventral region of SNpc exhibited the greatest increase of hypointensity. This increase in the lateral ventral region of SNpc robustly differentiated PD patients from controls. CONCLUSION: T2*-weighted hypointense signal in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD. It is most likely a measure sensitive to PD-related iron deposition and may serve as a robust biomarker of PD. © 2016 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/28004859/Parkinson's_disease_related_increase_of_T2__weighted_hypointensity_in_substantia_nigra_pars_compacta_ L2 - https://doi.org/10.1002/mds.26883 DB - PRIME DP - Unbound Medicine ER -