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Functional assessment of glottal insufficiency treated by hyaluronic acid injection: Retrospective 20-case series.
Eur Ann Otorhinolaryngol Head Neck Dis. 2017 May; 134(3):145-149.EA

Abstract

OBJECTIVES

The objectives of the present study were to describe hyaluronic acid injection to the vocal folds as treatment for glottal insufficiency, assess indications and report vocal results at 1 month and later than 6 months postoperatively.

PATIENTS AND METHODS

A single-center retrospective study was performed for the period March 2012 to August 2015. Inclusion criteria comprised: unilateral recurrent nerve palsy or vocal fold closure defect with conserved mobility. Exclusion criteria comprised: previous thyroplasty, severe swallowing disorder, and cognitive disorder hindering subjective vocal assessment. Restylane® injection was performed under general or local anesthesia. The Vocal Handicap Index (VHI), maximum phonation time (MPT) and GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) score were assessed preoperatively and at 1 month and more than 6 months postoperatively.

RESULTS

Twenty patients were included: 14 with unilateral recurrent nerve palsy and 6 with vocal fold closure defect. Restylane® injection was performed under general anesthesia in 16 patients and local anesthesia in 4 (20%). At 1-month assessment, there was significant reduction in VHI (by 36 points; P=0.0001) and GRBAS score (by 6.95 points; P=0.0001) and significant increase in MPT (by 4.95sec; P=0.0001). At 6 months, VHI, MPT and GRBAS scores remained significantly improved (respectively, P=0.0002, P=0.001 and P=0.0001), without significant difference from 1-month levels. Three patients had minor complications; two recovered normal vocal fold mobility.

CONCLUSION

Hyaluronic acid injection was effective in treating glottal failure, improving objective and subjective vocal parameters, which remained satisfactory even 6 months postoperatively.

Authors+Show Affiliations

Service d'ORL CHU Bretonneau, Université François-Rabelais Tours, 2, boulevard Tonnellé, 37000 Tours, France.Service d'ORL CHU Bretonneau, Université François-Rabelais Tours, 2, boulevard Tonnellé, 37000 Tours, France.Service d'ORL CHU Bretonneau, Université François-Rabelais Tours, 2, boulevard Tonnellé, 37000 Tours, France.Service d'ORL CHU Bretonneau, Université François-Rabelais Tours, 2, boulevard Tonnellé, 37000 Tours, France.Service d'ORL CHU Bretonneau, Université François-Rabelais Tours, 2, boulevard Tonnellé, 37000 Tours, France. Electronic address: moriniere@univ-tours.fr.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28007508

Citation

Dorbeau, C, et al. "Functional Assessment of Glottal Insufficiency Treated By Hyaluronic Acid Injection: Retrospective 20-case Series." European Annals of Otorhinolaryngology, Head and Neck Diseases, vol. 134, no. 3, 2017, pp. 145-149.
Dorbeau C, Marmouset F, Lescanne E, et al. Functional assessment of glottal insufficiency treated by hyaluronic acid injection: Retrospective 20-case series. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134(3):145-149.
Dorbeau, C., Marmouset, F., Lescanne, E., Bakhos, D., & Morinière, S. (2017). Functional assessment of glottal insufficiency treated by hyaluronic acid injection: Retrospective 20-case series. European Annals of Otorhinolaryngology, Head and Neck Diseases, 134(3), 145-149. https://doi.org/10.1016/j.anorl.2016.11.006
Dorbeau C, et al. Functional Assessment of Glottal Insufficiency Treated By Hyaluronic Acid Injection: Retrospective 20-case Series. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134(3):145-149. PubMed PMID: 28007508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional assessment of glottal insufficiency treated by hyaluronic acid injection: Retrospective 20-case series. AU - Dorbeau,C, AU - Marmouset,F, AU - Lescanne,E, AU - Bakhos,D, AU - Morinière,S, Y1 - 2016/12/20/ PY - 2016/12/23/pubmed PY - 2018/5/3/medline PY - 2016/12/24/entrez KW - Dysphonia KW - Hyaluronic acid KW - Laryngeal palsy KW - Larynx KW - Vocal folds KW - Voice SP - 145 EP - 149 JF - European annals of otorhinolaryngology, head and neck diseases JO - Eur Ann Otorhinolaryngol Head Neck Dis VL - 134 IS - 3 N2 - OBJECTIVES: The objectives of the present study were to describe hyaluronic acid injection to the vocal folds as treatment for glottal insufficiency, assess indications and report vocal results at 1 month and later than 6 months postoperatively. PATIENTS AND METHODS: A single-center retrospective study was performed for the period March 2012 to August 2015. Inclusion criteria comprised: unilateral recurrent nerve palsy or vocal fold closure defect with conserved mobility. Exclusion criteria comprised: previous thyroplasty, severe swallowing disorder, and cognitive disorder hindering subjective vocal assessment. Restylane® injection was performed under general or local anesthesia. The Vocal Handicap Index (VHI), maximum phonation time (MPT) and GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) score were assessed preoperatively and at 1 month and more than 6 months postoperatively. RESULTS: Twenty patients were included: 14 with unilateral recurrent nerve palsy and 6 with vocal fold closure defect. Restylane® injection was performed under general anesthesia in 16 patients and local anesthesia in 4 (20%). At 1-month assessment, there was significant reduction in VHI (by 36 points; P=0.0001) and GRBAS score (by 6.95 points; P=0.0001) and significant increase in MPT (by 4.95sec; P=0.0001). At 6 months, VHI, MPT and GRBAS scores remained significantly improved (respectively, P=0.0002, P=0.001 and P=0.0001), without significant difference from 1-month levels. Three patients had minor complications; two recovered normal vocal fold mobility. CONCLUSION: Hyaluronic acid injection was effective in treating glottal failure, improving objective and subjective vocal parameters, which remained satisfactory even 6 months postoperatively. SN - 1879-730X UR - https://www.unboundmedicine.com/medline/citation/28007508/Functional_assessment_of_glottal_insufficiency_treated_by_hyaluronic_acid_injection:_Retrospective_20_case_series_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1879-7296(16)30196-X DB - PRIME DP - Unbound Medicine ER -