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Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system.
Eur J Ophthalmol 2017; 27(1):e16-e21EJ

Abstract

PURPOSE

To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management.

METHODS

This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region.

RESULTS

Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode-retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks.

CONCLUSIONS

The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design.

Authors+Show Affiliations

Eye Clinic, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara - Italy.Eye Clinic, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara - Italy. Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy.Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy.Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy.Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy.Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28009400

Citation

Parmeggiani, Francesco, et al. "Optical Coherence Tomography Imaging in the Management of the Argus II Retinal Prosthesis System." European Journal of Ophthalmology, vol. 27, no. 1, 2017, pp. e16-e21.
Parmeggiani F, De Nadai K, Piovan A, et al. Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system. Eur J Ophthalmol. 2017;27(1):e16-e21.
Parmeggiani, F., De Nadai, K., Piovan, A., Binotto, A., Zamengo, S., & Chizzolini, M. (2017). Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system. European Journal of Ophthalmology, 27(1), pp. e16-e21. doi:10.5301/ejo.5000852.
Parmeggiani F, et al. Optical Coherence Tomography Imaging in the Management of the Argus II Retinal Prosthesis System. Eur J Ophthalmol. 2017 Jan 19;27(1):e16-e21. PubMed PMID: 28009400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system. AU - Parmeggiani,Francesco, AU - De Nadai,Katia, AU - Piovan,Angela, AU - Binotto,Andrea, AU - Zamengo,Sara, AU - Chizzolini,Marzio, Y1 - 2017/01/19/ PY - 2016/07/18/accepted PY - 2016/12/24/pubmed PY - 2017/3/10/medline PY - 2016/12/24/entrez SP - e16 EP - e21 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 27 IS - 1 N2 - PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region. RESULTS: Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode-retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks. CONCLUSIONS: The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/28009400/Optical_coherence_tomography_imaging_in_the_management_of_the_Argus_II_retinal_prosthesis_system_ L2 - http://journals.sagepub.com/doi/full/10.5301/ejo.5000852?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -