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Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration.
J Mol Biol. 2017 02 17; 429(4):543-561.JM

Abstract

Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes, namely cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover, we highlighted the cross-talk between nitric oxide and H2S in several bilogical contexts.

Authors+Show Affiliations

Department of Neuroscience and Regenerative Medicine, Augusta University, 1120 15th Street, CA 2018, Augusta, GA, 30907, USA. Electronic address: nsen@augusta.edu.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28013031

Citation

Sen, Nilkantha. "Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration." Journal of Molecular Biology, vol. 429, no. 4, 2017, pp. 543-561.
Sen N. Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration. J Mol Biol. 2017;429(4):543-561.
Sen, N. (2017). Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration. Journal of Molecular Biology, 429(4), 543-561. https://doi.org/10.1016/j.jmb.2016.12.015
Sen N. Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration. J Mol Biol. 2017 02 17;429(4):543-561. PubMed PMID: 28013031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration. A1 - Sen,Nilkantha, Y1 - 2016/12/21/ PY - 2016/10/05/received PY - 2016/12/08/revised PY - 2016/12/12/accepted PY - 2016/12/26/pubmed PY - 2017/8/2/medline PY - 2016/12/26/entrez KW - CBS KW - CSE KW - hydrogen sulfide KW - sulfhydration SP - 543 EP - 561 JF - Journal of molecular biology JO - J Mol Biol VL - 429 IS - 4 N2 - Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes, namely cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover, we highlighted the cross-talk between nitric oxide and H2S in several bilogical contexts. SN - 1089-8638 UR - https://www.unboundmedicine.com/medline/citation/28013031/Functional_and_Molecular_Insights_of_Hydrogen_Sulfide_Signaling_and_Protein_Sulfhydration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2836(16)30554-X DB - PRIME DP - Unbound Medicine ER -