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Sclerotherapy after variceal hemorrhage in noncirrhotic portal fibrosis.
Am J Gastroenterol. 1989 Oct; 84(10):1235-8.AJ

Abstract

Sixty patients with variceal bleeding due to noncirrhotic portal fibrosis were treated by repeated endoscopic injection sclerotherapy. During each session, the varices were injected with a mean volume of 14.4 ml of 1% polidocanol intravariceally. This decreased rebleeding, as evidenced by a reduction in mean bleeding risk factor and transfusion requirement. Difference between pre- and post-sclerotherapy parameters were significant (p less than 0.001). Variceal obliteration was achieved in 53 (88%) patients. The mean sclerotherapy sessions required for eradication were 8.43 (SD = 2.41). Minor complications related to the procedure occurred in 12% of patients. Cumulative survival for 5 yr was 86%. Survival was significantly related to Child's status, being 97.5% for Child's A and 64% for Child's B patients. Recurrence of varices occurred in 15% of patients after a mean interval of 19 months. We conclude that endoscopic sclerotherapy is an effective method of treatment for variceal bleeding due to non-cirrhotic portal fibrosis, and is a reasonable alternative to surgery.

Authors+Show Affiliations

Department of Gastroenterology and Biostatistics, All India Institute of Medical Sciences, New Delhi.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2801673

Citation

Bhargava, D K., et al. "Sclerotherapy After Variceal Hemorrhage in Noncirrhotic Portal Fibrosis." The American Journal of Gastroenterology, vol. 84, no. 10, 1989, pp. 1235-8.
Bhargava DK, Dwivedi M, Dasarathy S, et al. Sclerotherapy after variceal hemorrhage in noncirrhotic portal fibrosis. Am J Gastroenterol. 1989;84(10):1235-8.
Bhargava, D. K., Dwivedi, M., Dasarathy, S., & Sundaram, K. R. (1989). Sclerotherapy after variceal hemorrhage in noncirrhotic portal fibrosis. The American Journal of Gastroenterology, 84(10), 1235-8.
Bhargava DK, et al. Sclerotherapy After Variceal Hemorrhage in Noncirrhotic Portal Fibrosis. Am J Gastroenterol. 1989;84(10):1235-8. PubMed PMID: 2801673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sclerotherapy after variceal hemorrhage in noncirrhotic portal fibrosis. AU - Bhargava,D K, AU - Dwivedi,M, AU - Dasarathy,S, AU - Sundaram,K R, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 1235 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 84 IS - 10 N2 - Sixty patients with variceal bleeding due to noncirrhotic portal fibrosis were treated by repeated endoscopic injection sclerotherapy. During each session, the varices were injected with a mean volume of 14.4 ml of 1% polidocanol intravariceally. This decreased rebleeding, as evidenced by a reduction in mean bleeding risk factor and transfusion requirement. Difference between pre- and post-sclerotherapy parameters were significant (p less than 0.001). Variceal obliteration was achieved in 53 (88%) patients. The mean sclerotherapy sessions required for eradication were 8.43 (SD = 2.41). Minor complications related to the procedure occurred in 12% of patients. Cumulative survival for 5 yr was 86%. Survival was significantly related to Child's status, being 97.5% for Child's A and 64% for Child's B patients. Recurrence of varices occurred in 15% of patients after a mean interval of 19 months. We conclude that endoscopic sclerotherapy is an effective method of treatment for variceal bleeding due to non-cirrhotic portal fibrosis, and is a reasonable alternative to surgery. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/2801673/Sclerotherapy_after_variceal_hemorrhage_in_noncirrhotic_portal_fibrosis_ L2 - https://medlineplus.gov/gastrointestinalbleeding.html DB - PRIME DP - Unbound Medicine ER -