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Synopsis on Managment Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development.
Curr Top Med Chem. 2017; 17(12):1371-1378.CT

Abstract

The maintenance of health requires successful cell functioning, which in turn depends upon the proper and active conformation of proteins besides other biomolecules. However, occasionally these proteins may misfold and lead to the appearance and progression of protein conformational diseases. These diseases apart from others include several neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, and other lesser known diseases. Although much knowledge has been gained, these NDDs still warrant advance research in the elucidation of their mechanisms as well as effective therapeutic interventions and proper management. There is an ever-growing and urgent need to improve the diagnosis and management of NDDs due to their devastating nature, serious social impact and neuropsychiatric symptoms. It is also envisioned that we may be able to encourage, develop, and strengthen the cell defenses against amyloid toxicity and prevent neuronal destruction and consequently neurodegeneration. In this review, the implications of protein misfolding and aggregation in NDDs are discussed along with some of the most recent findings on the curative and beneficial effects of natural molecules such as polyphenols. This paper also reviews the anti-aggregation and protective effects of some organic and peptidic compounds duly supported experimentally, as prospective future therapeutics for NDDs. The synopses presented in this review shall prove helpful in further understanding of the causes, cures and management of lethal NDDs.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia. Novel Global Community Educational Foundation, Australia.Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Vishakhapatnam-530045, A.P., India.King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28017151

Citation

Bhat, Sheraz Ahmad, et al. "Synopsis On Managment Strategies for Neurodegenerative Disorders: Challenges From Bench to Bedside in Successful Drug Discovery and Development." Current Topics in Medicinal Chemistry, vol. 17, no. 12, 2017, pp. 1371-1378.
Bhat SA, Kamal MA, Yarla NS, et al. Synopsis on Managment Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development. Curr Top Med Chem. 2017;17(12):1371-1378.
Bhat, S. A., Kamal, M. A., Yarla, N. S., & Ashraf, G. M. (2017). Synopsis on Managment Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development. Current Topics in Medicinal Chemistry, 17(12), 1371-1378. https://doi.org/10.2174/1568026616666161222121229
Bhat SA, et al. Synopsis On Managment Strategies for Neurodegenerative Disorders: Challenges From Bench to Bedside in Successful Drug Discovery and Development. Curr Top Med Chem. 2017;17(12):1371-1378. PubMed PMID: 28017151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synopsis on Managment Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development. AU - Bhat,Sheraz Ahmad, AU - Kamal,Mohammad Amjad, AU - Yarla,Nagendra Sastry, AU - Ashraf,Ghulam Md, PY - 2015/08/12/received PY - 2015/12/16/revised PY - 2015/12/30/accepted PY - 2016/12/27/pubmed PY - 2017/7/6/medline PY - 2016/12/27/entrez KW - Aggregation KW - Alzheimer's disease KW - Amyotrophic lateral sclerosis KW - Conformational disease KW - Neurodegenerative disorders KW - Neuropsychiatry KW - Parkinson's disease SP - 1371 EP - 1378 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 17 IS - 12 N2 - The maintenance of health requires successful cell functioning, which in turn depends upon the proper and active conformation of proteins besides other biomolecules. However, occasionally these proteins may misfold and lead to the appearance and progression of protein conformational diseases. These diseases apart from others include several neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, and other lesser known diseases. Although much knowledge has been gained, these NDDs still warrant advance research in the elucidation of their mechanisms as well as effective therapeutic interventions and proper management. There is an ever-growing and urgent need to improve the diagnosis and management of NDDs due to their devastating nature, serious social impact and neuropsychiatric symptoms. It is also envisioned that we may be able to encourage, develop, and strengthen the cell defenses against amyloid toxicity and prevent neuronal destruction and consequently neurodegeneration. In this review, the implications of protein misfolding and aggregation in NDDs are discussed along with some of the most recent findings on the curative and beneficial effects of natural molecules such as polyphenols. This paper also reviews the anti-aggregation and protective effects of some organic and peptidic compounds duly supported experimentally, as prospective future therapeutics for NDDs. The synopses presented in this review shall prove helpful in further understanding of the causes, cures and management of lethal NDDs. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/28017151/Synopsis_on_Managment_Strategies_for_Neurodegenerative_Disorders:_Challenges_from_Bench_to_Bedside_in_Successful_Drug_Discovery_and_Development_ DB - PRIME DP - Unbound Medicine ER -