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Histoplasma capsulatum polysaccharide antigen detection in diagnosis and management of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome.
Am J Med. 1989 Oct; 87(4):396-400.AJ

Abstract

PURPOSE

Disseminated histoplasmosis is a serious and often rapidly progressive, opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), supporting the importance of rapid diagnostic tests. We investigated Histoplasma capsulatum polysaccharide antigen (HPA) detection, a promising new method for rapid diagnosis of histoplasmosis.

PATIENTS AND METHODS

Sixty-one cases of disseminated histoplasmosis in patients with AIDS form the basis of this report. Control cases were patients with AIDS who had other opportunistic infections and whose cultures were negative for H. capsulatum. A slightly modified radioimmunoassay procedure was used to measure the levels of HPA in urine and blood specimens.

RESULTS

High levels of HPA were detected in the urine of 59 of 61 (96.7%) and the blood of 37 of 47 (78.7%) patients with AIDS complicated by disseminated histoplasmosis. Treatment with amphotericin B reduced levels of HPA in the urine in 19 of 21 (90.5%) and the serum of all 10 patients tested. HPA levels increased in the urine in all eight and in the serum in all five patients with culture-proven relapse.

CONCLUSION

In conclusion, HPA detection offers a rapid method for diagnosing disseminated histoplasmosis. Additional experience is required to establish the role of this test in monitoring the effects of treatment and in identifying relapse in patients with AIDS.

Authors+Show Affiliations

Indiana University Medical Center, Wishard Memorial Hospital, Indianapolis.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2801730

Citation

Wheat, L J., et al. "Histoplasma Capsulatum Polysaccharide Antigen Detection in Diagnosis and Management of Disseminated Histoplasmosis in Patients With Acquired Immunodeficiency Syndrome." The American Journal of Medicine, vol. 87, no. 4, 1989, pp. 396-400.
Wheat LJ, Connolly-Stringfield P, Kohler RB, et al. Histoplasma capsulatum polysaccharide antigen detection in diagnosis and management of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. Am J Med. 1989;87(4):396-400.
Wheat, L. J., Connolly-Stringfield, P., Kohler, R. B., Frame, P. T., & Gupta, M. R. (1989). Histoplasma capsulatum polysaccharide antigen detection in diagnosis and management of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. The American Journal of Medicine, 87(4), 396-400.
Wheat LJ, et al. Histoplasma Capsulatum Polysaccharide Antigen Detection in Diagnosis and Management of Disseminated Histoplasmosis in Patients With Acquired Immunodeficiency Syndrome. Am J Med. 1989;87(4):396-400. PubMed PMID: 2801730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histoplasma capsulatum polysaccharide antigen detection in diagnosis and management of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. AU - Wheat,L J, AU - Connolly-Stringfield,P, AU - Kohler,R B, AU - Frame,P T, AU - Gupta,M R, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 396 EP - 400 JF - The American journal of medicine JO - Am J Med VL - 87 IS - 4 N2 - PURPOSE: Disseminated histoplasmosis is a serious and often rapidly progressive, opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), supporting the importance of rapid diagnostic tests. We investigated Histoplasma capsulatum polysaccharide antigen (HPA) detection, a promising new method for rapid diagnosis of histoplasmosis. PATIENTS AND METHODS: Sixty-one cases of disseminated histoplasmosis in patients with AIDS form the basis of this report. Control cases were patients with AIDS who had other opportunistic infections and whose cultures were negative for H. capsulatum. A slightly modified radioimmunoassay procedure was used to measure the levels of HPA in urine and blood specimens. RESULTS: High levels of HPA were detected in the urine of 59 of 61 (96.7%) and the blood of 37 of 47 (78.7%) patients with AIDS complicated by disseminated histoplasmosis. Treatment with amphotericin B reduced levels of HPA in the urine in 19 of 21 (90.5%) and the serum of all 10 patients tested. HPA levels increased in the urine in all eight and in the serum in all five patients with culture-proven relapse. CONCLUSION: In conclusion, HPA detection offers a rapid method for diagnosing disseminated histoplasmosis. Additional experience is required to establish the role of this test in monitoring the effects of treatment and in identifying relapse in patients with AIDS. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/2801730/Histoplasma_capsulatum_polysaccharide_antigen_detection_in_diagnosis_and_management_of_disseminated_histoplasmosis_in_patients_with_acquired_immunodeficiency_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(89)80820-4 DB - PRIME DP - Unbound Medicine ER -