Tags

Type your tag names separated by a space and hit enter

Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: An Update Meta-analysis.
Front Pharmacol. 2016; 7:489.FP

Abstract

Background:

Acute pancreatitis is the most common serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Although, somatostatin (SOM) has been used in the prevention of post-ERCP pancreatitis (PEP), the efficacy of SOM remains inconsistent.

Methods:

Electronic databases, including PubMed/MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), and the Science Citation Index were searched to retrieve relevant studies. Details of the study population, including patients' characteristics, sample size, regimen of drug administration and incidence of PEP, hyperamylasemia and abdominal pain were extracted by two investigators. Data were analyzed with Review Manager 5.3 software.

Results:

Eleven randomized controlled trials, enrolling a total of 4192 patients, were included in the meta-analysis. After data were pooled, we observed decreased incidence of ERCP-induced outcomes, such as PEP (RR = 0.63, 95% CI: 0.40, 0.98; P = 0.04) and hyperamylasemia (RR = 0.75, 95% CI: 0.66, 0.84; P < 0.001) in patients treated with SOM than those with placebo. Subgroup analysis by ethnicity found decreased incidence of PEP and hyperamylasemia in Asia only. Subgroup analysis by treatment schedule and dosage revealed decreased incidence of PEP and hyperamylasemia when SOM were treated with a single bolus or long-term infusion, or at dose above 3000 μg. We did not observed efficacy of SOM on abdominal pain in pooled or subgroup analysis.

Conclusion:

This meta-analysis of patients undergoing ERCP showed reduced incidence of PEP and hyperamylasemia when SOM was administrated with single bolus, long-term infusion, or high dosage. More data are needed to confirm our findings.

Authors+Show Affiliations

Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.Department of Gastroenterology, Fu Xing Hospital, Capital Medical University Beijing, China.

Pub Type(s)

Review
Journal Article

Language

eng

PubMed ID

28018225

Citation

Hu, Jing, et al. "Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: an Update Meta-analysis." Frontiers in Pharmacology, vol. 7, 2016, p. 489.
Hu J, Li PL, Zhang T, et al. Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: An Update Meta-analysis. Front Pharmacol. 2016;7:489.
Hu, J., Li, P. L., Zhang, T., Chen, J. P., Hu, Y. J., Yu, Z., Wang, J. P., Zhu, D., & Tong, X. F. (2016). Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: An Update Meta-analysis. Frontiers in Pharmacology, 7, 489. https://doi.org/10.3389/fphar.2016.00489
Hu J, et al. Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: an Update Meta-analysis. Front Pharmacol. 2016;7:489. PubMed PMID: 28018225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Somatostatin in Preventing Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: An Update Meta-analysis. AU - Hu,Jing, AU - Li,Pei-Lin, AU - Zhang,Tao, AU - Chen,Jin-Ping, AU - Hu,Yao-Jun, AU - Yu,Zheng, AU - Wang,Jin-Peng, AU - Zhu,Dan, AU - Tong,Xiao-Fei, Y1 - 2016/12/15/ PY - 2016/07/20/received PY - 2016/11/29/accepted PY - 2016/12/27/entrez PY - 2016/12/27/pubmed PY - 2016/12/27/medline KW - endoscopic retrograde cholangiopancreatography KW - hyperamylasemia KW - meta-analysis KW - pancreatitis KW - somatostatin SP - 489 EP - 489 JF - Frontiers in pharmacology JO - Front Pharmacol VL - 7 N2 - Background: Acute pancreatitis is the most common serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Although, somatostatin (SOM) has been used in the prevention of post-ERCP pancreatitis (PEP), the efficacy of SOM remains inconsistent. Methods: Electronic databases, including PubMed/MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), and the Science Citation Index were searched to retrieve relevant studies. Details of the study population, including patients' characteristics, sample size, regimen of drug administration and incidence of PEP, hyperamylasemia and abdominal pain were extracted by two investigators. Data were analyzed with Review Manager 5.3 software. Results: Eleven randomized controlled trials, enrolling a total of 4192 patients, were included in the meta-analysis. After data were pooled, we observed decreased incidence of ERCP-induced outcomes, such as PEP (RR = 0.63, 95% CI: 0.40, 0.98; P = 0.04) and hyperamylasemia (RR = 0.75, 95% CI: 0.66, 0.84; P < 0.001) in patients treated with SOM than those with placebo. Subgroup analysis by ethnicity found decreased incidence of PEP and hyperamylasemia in Asia only. Subgroup analysis by treatment schedule and dosage revealed decreased incidence of PEP and hyperamylasemia when SOM were treated with a single bolus or long-term infusion, or at dose above 3000 μg. We did not observed efficacy of SOM on abdominal pain in pooled or subgroup analysis. Conclusion: This meta-analysis of patients undergoing ERCP showed reduced incidence of PEP and hyperamylasemia when SOM was administrated with single bolus, long-term infusion, or high dosage. More data are needed to confirm our findings. SN - 1663-9812 UR - https://www.unboundmedicine.com/medline/citation/28018225/Role_of_Somatostatin_in_Preventing_Post_endoscopic_Retrograde_Cholangiopancreatography__ERCP__Pancreatitis:_An_Update_Meta_analysis_ L2 - https://doi.org/10.3389/fphar.2016.00489 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.