Tags

Type your tag names separated by a space and hit enter

A young child of anti-NMDA receptor encephalitis presenting with epilepsia partialis continua: the first pediatric case in Korea.
Korean J Pediatr. 2016 Nov; 59(Suppl 1):S133-S138.KJ

Abstract

Anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis, recently recognized as a form of paraneoplastic encephalitis, is characterized by a prodromal phase of unspecific illness with fever that resembles a viral disease. The prodromal phase is followed by seizures, disturbed consciousness, psychiatric features, prominent abnormal movements, and autonomic imbalance. Here, we report a case of anti-NMDAR encephalitis with initial symptoms of epilepsia partialis continua in the absence of tumor. Briefly, a 3-year-old girl was admitted to the hospital due to right-sided, complex partial seizures without preceding febrile illness. The seizures evolved into epilepsia partialis continua and were accompanied by epileptiform discharges from the left frontal area. Three weeks after admission, the patient's seizures were reduced with antiepileptic drugs; however, she developed sleep disturbances, cognitive decline, noticeable oro-lingual-facial dyskinesia, and choreoathetoid movements. Anti-NMDAR encephalitis was confirmed by positive detection of NMDAR antibodies in the patient's serum and cerebrospinal fluid, and her condition slowly improved with immunoglobulin, methylprednisolone, and rituximab. At present, the patient is no longer taking multiple antiepileptic or antihypertensive drugs. Moreover, the patient showed gradual improvement of motor and cognitive function. This case serves as an example that a diagnosis of anti-NMDAR encephalitis should be considered when children with uncontrolled seizures develop dyskinesias without evidence of malignant tumor. In these cases, aggressive immunotherapies are needed to improve the outcome of anti-NMDAR encephalitis.

Authors+Show Affiliations

Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28018466

Citation

Kim, Eun-Hee, et al. "A Young Child of anti-NMDA Receptor Encephalitis Presenting With Epilepsia Partialis Continua: the First Pediatric Case in Korea." Korean Journal of Pediatrics, vol. 59, no. Suppl 1, 2016, pp. S133-S138.
Kim EH, Kim YJ, Ko TS, et al. A young child of anti-NMDA receptor encephalitis presenting with epilepsia partialis continua: the first pediatric case in Korea. Korean journal of pediatrics. 2016;59(Suppl 1):S133-S138.
Kim, E. H., Kim, Y. J., Ko, T. S., Yum, M. S., & Lee, J. H. (2016). A young child of anti-NMDA receptor encephalitis presenting with epilepsia partialis continua: the first pediatric case in Korea. Korean Journal of Pediatrics, 59(Suppl 1), S133-S138. https://doi.org/10.3345/kjp.2016.59.11.S133
Kim EH, et al. A Young Child of anti-NMDA Receptor Encephalitis Presenting With Epilepsia Partialis Continua: the First Pediatric Case in Korea. Korean journal of pediatrics. 2016;59(Suppl 1):S133-S138. PubMed PMID: 28018466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A young child of anti-NMDA receptor encephalitis presenting with epilepsia partialis continua: the first pediatric case in Korea. AU - Kim,Eun-Hee, AU - Kim,Yeo Jin, AU - Ko,Tae-Sung, AU - Yum,Mi-Sun, AU - Lee,Jun Hwa, Y1 - 2016/11/30/ PY - 2014/09/30/received PY - 2014/12/12/revised PY - 2015/01/23/accepted PY - 2016/12/27/entrez PY - 2016/12/27/pubmed PY - 2016/12/27/medline KW - Anti-N-methyl-D-aspartate receptor encephalitis KW - Child KW - Epilepsia partialis continua SP - S133 EP - S138 JF - Korean journal of pediatrics VL - 59 IS - Suppl 1 N2 - Anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis, recently recognized as a form of paraneoplastic encephalitis, is characterized by a prodromal phase of unspecific illness with fever that resembles a viral disease. The prodromal phase is followed by seizures, disturbed consciousness, psychiatric features, prominent abnormal movements, and autonomic imbalance. Here, we report a case of anti-NMDAR encephalitis with initial symptoms of epilepsia partialis continua in the absence of tumor. Briefly, a 3-year-old girl was admitted to the hospital due to right-sided, complex partial seizures without preceding febrile illness. The seizures evolved into epilepsia partialis continua and were accompanied by epileptiform discharges from the left frontal area. Three weeks after admission, the patient's seizures were reduced with antiepileptic drugs; however, she developed sleep disturbances, cognitive decline, noticeable oro-lingual-facial dyskinesia, and choreoathetoid movements. Anti-NMDAR encephalitis was confirmed by positive detection of NMDAR antibodies in the patient's serum and cerebrospinal fluid, and her condition slowly improved with immunoglobulin, methylprednisolone, and rituximab. At present, the patient is no longer taking multiple antiepileptic or antihypertensive drugs. Moreover, the patient showed gradual improvement of motor and cognitive function. This case serves as an example that a diagnosis of anti-NMDAR encephalitis should be considered when children with uncontrolled seizures develop dyskinesias without evidence of malignant tumor. In these cases, aggressive immunotherapies are needed to improve the outcome of anti-NMDAR encephalitis. SN - 1738-1061 UR - https://www.unboundmedicine.com/medline/citation/28018466/A_young_child_of_anti_NMDA_receptor_encephalitis_presenting_with_epilepsia_partialis_continua:_the_first_pediatric_case_in_Korea_ L2 - https://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2016.59.11.S133 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.