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Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms.
Cancer Causes Control. 2017 02; 28(2):107-115.CC

Abstract

PURPOSE

Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase.

METHODS

The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis.

RESULTS

The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24).

CONCLUSION

Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.

Authors+Show Affiliations

Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea.Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28025763

Citation

Nam, Ji Hyung, et al. "Helicobacter Pylori Infection Is an Independent Risk Factor for Colonic Adenomatous Neoplasms." Cancer Causes & Control : CCC, vol. 28, no. 2, 2017, pp. 107-115.
Nam JH, Hong CW, Kim BC, et al. Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. Cancer Causes Control. 2017;28(2):107-115.
Nam, J. H., Hong, C. W., Kim, B. C., Shin, A., Ryu, K. H., Park, B. J., Kim, B., Sohn, D. K., Han, K. S., Kim, J., & Lee, C. W. (2017). Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. Cancer Causes & Control : CCC, 28(2), 107-115. https://doi.org/10.1007/s10552-016-0839-x
Nam JH, et al. Helicobacter Pylori Infection Is an Independent Risk Factor for Colonic Adenomatous Neoplasms. Cancer Causes Control. 2017;28(2):107-115. PubMed PMID: 28025763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. AU - Nam,Ji Hyung, AU - Hong,Chang Won, AU - Kim,Byung Chang, AU - Shin,Aesun, AU - Ryu,Kum Hei, AU - Park,Bum Joon, AU - Kim,Bun, AU - Sohn,Dae Kyung, AU - Han,Kyung Su, AU - Kim,Jeongseon, AU - Lee,Chan Wha, Y1 - 2016/12/27/ PY - 2016/08/25/received PY - 2016/12/19/accepted PY - 2016/12/28/pubmed PY - 2017/7/1/medline PY - 2016/12/28/entrez KW - Adenoma KW - Colonoscopy KW - H. Pylori KW - Risk factor SP - 107 EP - 115 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 28 IS - 2 N2 - PURPOSE: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase. METHODS: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis. RESULTS: The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24). CONCLUSION: Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/28025763/Helicobacter_pylori_infection_is_an_independent_risk_factor_for_colonic_adenomatous_neoplasms_ L2 - https://doi.org/10.1007/s10552-016-0839-x DB - PRIME DP - Unbound Medicine ER -