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Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence.
Neurourol Urodyn. 2017 04; 36(4):902-908.NU

Abstract

AIMS

To assess the long-term patient reported outcomes following transobturator tension-free vaginal tapes (TO-TVT) in women with urodynamic mixed urinary incontinence (MUI).

METHODS

A secondary analysis of the 9-year follow-up of the E-TOT study: 341 women with predominant stress urinary incontinence symptoms were randomized to undergo either inside-out or outside-in TO-TVT between April 2005 and April 2007. Forty-eight women had preoperative urodynamic MUI and were available for 9-year follow-up. Primary outcome was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement PGI-I. Secondary outcomes included impact on women's quality of life, sexual function, overactive bladder symptoms,and late adverse events. Statistical analysis was performed using SPSS v.23.

RESULTS

Forty-eight women completed the 9-year follow-up, with adjusted response rate of 63%. The success based on the PGI-I was 64.6% (n = 31), with a further 14.6% (n = 7) who reported "improved." There was no significant difference between groups (OR 1.11; 95%CI 0.33, 3.70; P > 0.999). Clinically significant improvement in quality of life was found in 85.3%. Cure of urgency and UUI was reported by 35% and 41%, whereas worsening was reported in 6.5% and 2.3%, respectively. One patient reported chronic groin/leg pain. The small sample size and the sizeable loss to follow-up are limitations in this study.

CONCLUSIONS

This is the first study to report the long-term outcomes of TO-TVT in women with urodynamic MUI; TO-TVT is associated with a good and sustained patient-reported success rate in women with MUI up to 9-years follow-up.

Authors+Show Affiliations

Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland.University of Aberdeen, Aberdeen, Scotland.University of Aberdeen, Aberdeen, Scotland.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28028822

Citation

Abdel-Fattah, Mohamed, et al. "Long-term Outcomes for Transobturator Tension-free Vaginal Tapes in Women With Urodynamic Mixed Urinary Incontinence." Neurourology and Urodynamics, vol. 36, no. 4, 2017, pp. 902-908.
Abdel-Fattah M, Cao G, Mostafa A. Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence. Neurourol Urodyn. 2017;36(4):902-908.
Abdel-Fattah, M., Cao, G., & Mostafa, A. (2017). Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence. Neurourology and Urodynamics, 36(4), 902-908. https://doi.org/10.1002/nau.23192
Abdel-Fattah M, Cao G, Mostafa A. Long-term Outcomes for Transobturator Tension-free Vaginal Tapes in Women With Urodynamic Mixed Urinary Incontinence. Neurourol Urodyn. 2017;36(4):902-908. PubMed PMID: 28028822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence. AU - Abdel-Fattah,Mohamed, AU - Cao,Gabriel, AU - Mostafa,Alyaa, Y1 - 2016/12/28/ PY - 2016/09/20/received PY - 2016/11/21/accepted PY - 2016/12/29/pubmed PY - 2017/6/18/medline PY - 2016/12/29/entrez KW - mid-urethral slings KW - stress urinary incontinence KW - tension-free vaginal tape KW - transobturator tapes KW - urinary incontinence SP - 902 EP - 908 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 36 IS - 4 N2 - AIMS: To assess the long-term patient reported outcomes following transobturator tension-free vaginal tapes (TO-TVT) in women with urodynamic mixed urinary incontinence (MUI). METHODS: A secondary analysis of the 9-year follow-up of the E-TOT study: 341 women with predominant stress urinary incontinence symptoms were randomized to undergo either inside-out or outside-in TO-TVT between April 2005 and April 2007. Forty-eight women had preoperative urodynamic MUI and were available for 9-year follow-up. Primary outcome was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement PGI-I. Secondary outcomes included impact on women's quality of life, sexual function, overactive bladder symptoms,and late adverse events. Statistical analysis was performed using SPSS v.23. RESULTS: Forty-eight women completed the 9-year follow-up, with adjusted response rate of 63%. The success based on the PGI-I was 64.6% (n = 31), with a further 14.6% (n = 7) who reported "improved." There was no significant difference between groups (OR 1.11; 95%CI 0.33, 3.70; P > 0.999). Clinically significant improvement in quality of life was found in 85.3%. Cure of urgency and UUI was reported by 35% and 41%, whereas worsening was reported in 6.5% and 2.3%, respectively. One patient reported chronic groin/leg pain. The small sample size and the sizeable loss to follow-up are limitations in this study. CONCLUSIONS: This is the first study to report the long-term outcomes of TO-TVT in women with urodynamic MUI; TO-TVT is associated with a good and sustained patient-reported success rate in women with MUI up to 9-years follow-up. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/28028822/Long_term_outcomes_for_transobturator_tension_free_vaginal_tapes_in_women_with_urodynamic_mixed_urinary_incontinence_ L2 - https://doi.org/10.1002/nau.23192 DB - PRIME DP - Unbound Medicine ER -