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Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity.
J Asian Nat Prod Res. 2017 Aug; 19(8):774-779.JA

Abstract

Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wu HY
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
Sheng Y
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
Kan XQ
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
Mou LY
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
Hu QF
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
Li GP
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.

MeSH

5-alpha Reductase InhibitorsDrugs, Chinese HerbalMolecular StructureNuclear Magnetic Resonance, BiomolecularSwertiaXanthones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28030961

Citation

Wu, Hai-Yan, et al. "Three New Xanthones From Swertia Bimaculata and Their Anti-5α-reductase Activity." Journal of Asian Natural Products Research, vol. 19, no. 8, 2017, pp. 774-779.
Wu HY, Sheng Y, Kan XQ, et al. Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity. J Asian Nat Prod Res. 2017;19(8):774-779.
Wu, H. Y., Sheng, Y., Kan, X. Q., Mou, L. Y., Hu, Q. F., & Li, G. P. (2017). Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity. Journal of Asian Natural Products Research, 19(8), 774-779. https://doi.org/10.1080/10286020.2016.1264392
Wu HY, et al. Three New Xanthones From Swertia Bimaculata and Their Anti-5α-reductase Activity. J Asian Nat Prod Res. 2017;19(8):774-779. PubMed PMID: 28030961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity. AU - Wu,Hai-Yan, AU - Sheng,Yu, AU - Kan,Xue-Qin, AU - Mou,Lin-Yun, AU - Hu,Qiu-Feng, AU - Li,Gan-Peng, Y1 - 2016/12/29/ PY - 2016/12/30/pubmed PY - 2017/9/2/medline PY - 2016/12/30/entrez KW - Gentianaceae KW - Swertia bimaculata KW - anti-5α-reductase activity KW - xanthones SP - 774 EP - 779 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 19 IS - 8 N2 - Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/28030961/Three_new_xanthones_from_Swertia_bimaculata_and_their_anti_5α_reductase_activity_ DB - PRIME DP - Unbound Medicine ER -