Abstract
CONTEXT
Assessment of natural polymers in oral controlled drug delivery.
OBJECTIVE
The objective of the present investigation was to assess of Araucaria gum (AHG) obtained from bark exudates of the Araucaria heterophylla (family: Araucariaceae) for the design of oral controlled release forms, in particular tablet dosage forms by using matrix systems. Diclofenac sodium was used as model drug and compared with the marketed formulation.
METHOD
Matrix tablets were prepared by wet granulation technique and 5% w/v of AHG dispersion water was used as granulating agent for preparation of AHG matrix tablets.
RESULTS
AHD2 (3:20) was found to be the optimized formulation based on in vitro drug dissolution studies. FTIR and DSC studies performed on the optimized formulations indicated no drug-polymer interaction. AHD2 (3:20) was found to be stable after accelerated stability testing for 6 months as per ICH guidelines. Pharmacokinetic studies of the optimized formulation were performed in healthy Albino Wister rabbits in comparison with that of the pure drug by estimating pharmacokinetic parameters and mean residence time (MRT). It was found that there is a significant increase in the bioavailability of diclofenac sodium from AHD2 formulation which was evident from the high AUC and MRT values compared with the pure drug.
CONCLUSION
The above results clearly indicated that AHG gum can be used for the development of oral controlled release dosage forms by using matrix systems.
TY - JOUR
T1 - Araucaria Gum: Novel Natural Polymer for Controlled Drug Delivery. Development, In Vitro and In Vivo Evaluation of Araucaria Gum Based Matrix Tablets for Controlled Release.
AU - Naga Durga,Divvela Hema,
AU - Lohithasu,Duppala,
AU - Ramana Murthy Kolapalli,Venkata,
PY - 2016/04/19/received
PY - 2016/11/17/revised
PY - 2016/11/25/accepted
PY - 2016/12/31/pubmed
PY - 2018/6/29/medline
PY - 2016/12/31/entrez
KW - Araucaria gum
KW - bioavailability
KW - controlled release
KW - diclofenac sodium
KW - matrix tablets
KW - pharmacokinetic
SP - 955
EP - 967
JF - Current drug delivery
JO - Curr Drug Deliv
VL - 14
IS - 7
N2 - CONTEXT: Assessment of natural polymers in oral controlled drug delivery. OBJECTIVE: The objective of the present investigation was to assess of Araucaria gum (AHG) obtained from bark exudates of the Araucaria heterophylla (family: Araucariaceae) for the design of oral controlled release forms, in particular tablet dosage forms by using matrix systems. Diclofenac sodium was used as model drug and compared with the marketed formulation. METHOD: Matrix tablets were prepared by wet granulation technique and 5% w/v of AHG dispersion water was used as granulating agent for preparation of AHG matrix tablets. RESULTS: AHD2 (3:20) was found to be the optimized formulation based on in vitro drug dissolution studies. FTIR and DSC studies performed on the optimized formulations indicated no drug-polymer interaction. AHD2 (3:20) was found to be stable after accelerated stability testing for 6 months as per ICH guidelines. Pharmacokinetic studies of the optimized formulation were performed in healthy Albino Wister rabbits in comparison with that of the pure drug by estimating pharmacokinetic parameters and mean residence time (MRT). It was found that there is a significant increase in the bioavailability of diclofenac sodium from AHD2 formulation which was evident from the high AUC and MRT values compared with the pure drug. CONCLUSION: The above results clearly indicated that AHG gum can be used for the development of oral controlled release dosage forms by using matrix systems.
SN - 1875-5704
UR - https://www.unboundmedicine.com/medline/citation/28034362/Araucaria_Gum:_Novel_Natural_Polymer_for_Controlled_Drug_Delivery__Development_In_Vitro_and_In_Vivo_Evaluation_of_Araucaria_Gum_Based_Matrix_Tablets_for_Controlled_Release_
DB - PRIME
DP - Unbound Medicine
ER -
