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Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years.
Environ Pollut. 2017 Mar; 222:307-314.EP

Abstract

Parabens, known as ubiquitous preservatives, have been linked to adverse health outcomes in humans. This study aimed to examine urinary paraben concentrations of children at 3 years of age and evaluate their associations with anthropometric parameters. Urinary parabens including methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) and benzylparaben (BeP) were measured among 436 children in a birth cohort using gas chromatography with tandem mass spectrometry. Generalized linear models were performed to evaluate associations of paraben exposures with age- and sex-specific z scores, including weight, height, weight for height and body mass index. MeP, EtP and PrP were the dominant parabens in urinary samples, with the median concentrations of 6.03 μg/L, 3.17 μg/L, 2.40 μg/L, respectively. The median values of estimated daily intake (EDIurine) of five urinary paraben concentrations were 12.10, 5.68, 4.50, 0.06 and 0.17 μg/kg-body weight/day, respectively. Urinary EtP concentrations were positively associated with weight z scores [regression coefficient β = 0.16, 95% confidence interval (CI): 0.04, 0.29; p = 0.01] and height z scores (β = 0.15, 95% CI: 0.03, 0.27; p = 0.01). Positive associations were found between the sum of molar concentrations of five parabens and height z scores among all children (β = 0.24, 95% CI: 0.04, 0.45; p = 0.02). These significant associations were only observed in boys. Our findings suggest that exposure to parabens may be adversely associated with physical growth in 3-year-old boy children. Further prospective studies are warranted to understand the toxicological mechanisms of paraben exposures and potential risk of children.

Authors+Show Affiliations

School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China. Electronic address: chwu@shmu.edu.cn.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China; Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China; Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.Shanghai Center for Disease Control and Prevention, No.39 Yunwushan Road, Changning District, Shanghai 200051, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.Shanghai Center for Disease Control and Prevention, No.39 Yunwushan Road, Changning District, Shanghai 200051, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28034559

Citation

Guo, Jianqiu, et al. "Urinary Paraben Concentrations and Their Associations With Anthropometric Measures of Children Aged 3 Years." Environmental Pollution (Barking, Essex : 1987), vol. 222, 2017, pp. 307-314.
Guo J, Wu C, Lu D, et al. Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years. Environ Pollut. 2017;222:307-314.
Guo, J., Wu, C., Lu, D., Jiang, S., Liang, W., Chang, X., Xu, H., Wang, G., & Zhou, Z. (2017). Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years. Environmental Pollution (Barking, Essex : 1987), 222, 307-314. https://doi.org/10.1016/j.envpol.2016.12.040
Guo J, et al. Urinary Paraben Concentrations and Their Associations With Anthropometric Measures of Children Aged 3 Years. Environ Pollut. 2017;222:307-314. PubMed PMID: 28034559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years. AU - Guo,Jianqiu, AU - Wu,Chunhua, AU - Lu,Dasheng, AU - Jiang,Shuai, AU - Liang,Weijiu, AU - Chang,Xiuli, AU - Xu,Hao, AU - Wang,Guoquan, AU - Zhou,Zhijun, Y1 - 2016/12/26/ PY - 2016/05/17/received PY - 2016/12/15/revised PY - 2016/12/16/accepted PY - 2016/12/31/pubmed PY - 2017/4/12/medline PY - 2016/12/31/entrez KW - Anthropometric measures KW - Child health KW - Exposure assessment KW - Parabens KW - Urine SP - 307 EP - 314 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ. Pollut. VL - 222 N2 - Parabens, known as ubiquitous preservatives, have been linked to adverse health outcomes in humans. This study aimed to examine urinary paraben concentrations of children at 3 years of age and evaluate their associations with anthropometric parameters. Urinary parabens including methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) and benzylparaben (BeP) were measured among 436 children in a birth cohort using gas chromatography with tandem mass spectrometry. Generalized linear models were performed to evaluate associations of paraben exposures with age- and sex-specific z scores, including weight, height, weight for height and body mass index. MeP, EtP and PrP were the dominant parabens in urinary samples, with the median concentrations of 6.03 μg/L, 3.17 μg/L, 2.40 μg/L, respectively. The median values of estimated daily intake (EDIurine) of five urinary paraben concentrations were 12.10, 5.68, 4.50, 0.06 and 0.17 μg/kg-body weight/day, respectively. Urinary EtP concentrations were positively associated with weight z scores [regression coefficient β = 0.16, 95% confidence interval (CI): 0.04, 0.29; p = 0.01] and height z scores (β = 0.15, 95% CI: 0.03, 0.27; p = 0.01). Positive associations were found between the sum of molar concentrations of five parabens and height z scores among all children (β = 0.24, 95% CI: 0.04, 0.45; p = 0.02). These significant associations were only observed in boys. Our findings suggest that exposure to parabens may be adversely associated with physical growth in 3-year-old boy children. Further prospective studies are warranted to understand the toxicological mechanisms of paraben exposures and potential risk of children. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/28034559/Urinary_paraben_concentrations_and_their_associations_with_anthropometric_measures_of_children_aged_3_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(16)32719-1 DB - PRIME DP - Unbound Medicine ER -