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Effect of Vascular Risk Factors on the Progression of Mild Alzheimer's Disease and Lewy Body Dementia.
J Alzheimers Dis 2017; 56(2):575-584JA

Abstract

BACKGROUND

Vascular risk factors (VRF) are associated with an increased risk of neurodegenerative disease.

OBJECTIVE

To examine the association between VRF and cognitive decline in patients with Alzheimer's disease (AD) and Lewy body dementia (LBD).

METHODS

We included consecutive referrals with mild AD or LBD to dementia clinics in western Norway from 2005 to 2013. The Mini-Mental Status Exam (MMSE) and Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) were administered at baseline and then annually for up to five years. The VRF include diabetes mellitus, hypertension, hypercholesterolemia, overweight and smoking. Generalized Estimating Equations (GEE) were used to examine the potential association between VRF scores and the change in MMSE and CDR-SB scores, adjusting for age, sex, and the apolipoprotein ɛ4 allele (APOE4).

RESULTS

A total of 200 patients were included (113 AD, 87 LBD) (mean age 76 years, mean baseline MMSE 24.0, mean follow-up time 3.5 years). Smoking was the only VRF significantly associated with a more rapid cognitive decline, however only in the AD group. Being overweight at baseline was associated with a slower cognitive decline. Moreover, hypertension at baseline predicted a slower decline in MMSE scores. In the LBD group diabetes mellitus was found to be associated with a slower increase in CDR-SB scores.

CONCLUSION

With the exception of smoking, VRF at time of dementia diagnosis were not associated with a more rapid cognitive decline.

Authors+Show Affiliations

Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway. Department of Clinical Sciences, University of Bergen, Bergen, Norway.Department of Research, Section of Biostatistics, Stavanger University Hospital, Stavanger, Norway.Department of Clinical Sciences, University of Bergen, Bergen, Norway. Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway. Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28035932

Citation

Bergland, Anne Katrine, et al. "Effect of Vascular Risk Factors On the Progression of Mild Alzheimer's Disease and Lewy Body Dementia." Journal of Alzheimer's Disease : JAD, vol. 56, no. 2, 2017, pp. 575-584.
Bergland AK, Dalen I, Larsen AI, et al. Effect of Vascular Risk Factors on the Progression of Mild Alzheimer's Disease and Lewy Body Dementia. J Alzheimers Dis. 2017;56(2):575-584.
Bergland, A. K., Dalen, I., Larsen, A. I., Aarsland, D., & Soennesyn, H. (2017). Effect of Vascular Risk Factors on the Progression of Mild Alzheimer's Disease and Lewy Body Dementia. Journal of Alzheimer's Disease : JAD, 56(2), pp. 575-584. doi:10.3233/JAD-160847.
Bergland AK, et al. Effect of Vascular Risk Factors On the Progression of Mild Alzheimer's Disease and Lewy Body Dementia. J Alzheimers Dis. 2017;56(2):575-584. PubMed PMID: 28035932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Vascular Risk Factors on the Progression of Mild Alzheimer's Disease and Lewy Body Dementia. AU - Bergland,Anne Katrine, AU - Dalen,Ingvild, AU - Larsen,Alf Inge, AU - Aarsland,Dag, AU - Soennesyn,Hogne, PY - 2016/12/31/pubmed PY - 2018/2/24/medline PY - 2016/12/31/entrez KW - Alzheimer’s disease KW - Lewy body dementia KW - dementia KW - progression KW - vascular risk factors SP - 575 EP - 584 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 56 IS - 2 N2 - BACKGROUND: Vascular risk factors (VRF) are associated with an increased risk of neurodegenerative disease. OBJECTIVE: To examine the association between VRF and cognitive decline in patients with Alzheimer's disease (AD) and Lewy body dementia (LBD). METHODS: We included consecutive referrals with mild AD or LBD to dementia clinics in western Norway from 2005 to 2013. The Mini-Mental Status Exam (MMSE) and Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) were administered at baseline and then annually for up to five years. The VRF include diabetes mellitus, hypertension, hypercholesterolemia, overweight and smoking. Generalized Estimating Equations (GEE) were used to examine the potential association between VRF scores and the change in MMSE and CDR-SB scores, adjusting for age, sex, and the apolipoprotein ɛ4 allele (APOE4). RESULTS: A total of 200 patients were included (113 AD, 87 LBD) (mean age 76 years, mean baseline MMSE 24.0, mean follow-up time 3.5 years). Smoking was the only VRF significantly associated with a more rapid cognitive decline, however only in the AD group. Being overweight at baseline was associated with a slower cognitive decline. Moreover, hypertension at baseline predicted a slower decline in MMSE scores. In the LBD group diabetes mellitus was found to be associated with a slower increase in CDR-SB scores. CONCLUSION: With the exception of smoking, VRF at time of dementia diagnosis were not associated with a more rapid cognitive decline. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/28035932/Effect_of_Vascular_Risk_Factors_on_the_Progression_of_Mild_Alzheimer's_Disease_and_Lewy_Body_Dementia_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-160847 DB - PRIME DP - Unbound Medicine ER -