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Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology.

Abstract

BACKGROUND

Cancer and Alzheimer's disease (AD) are common diseases of aging and share many risk factors. Surprisingly, however, epidemiologic data from several recent independent cohort studies suggest that there may be an inverse association between these diseases.

OBJECTIVE

To determine the relationship between history of cancer and odds of dementia proximate to death and neuropathological indices of AD.

METHODS

Using data from two separate clinical-pathologic cohort studies of aging and AD, the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP), we compared odds of AD dementia proximate to death among participants with and without a history of cancer. We then examined the relation of history of cancer with measures of AD pathology at autopsy, i.e., paired helical filament tau (PHFtau) neurofibrillary tangles and amyloid-β load.

RESULTS

Participants reporting a history of cancer had significantly lower odds of AD (OR 0.70 [0.55-0.89], p = 0.0040) proximate to death as compared to participants reporting no prior history of cancer. The results remained significant after adjusting for multiple risk factors including age, sex, race, education, and presence of an APOEɛ4 allele. At autopsy, participants with a history of cancer had significantly fewer PHFtau tangles (p < 0.001) than participants without a history of cancer, but similar levels of amyloid-β.

CONCLUSIONS

Cancer survivors have reduced odds of developing AD and a lower burden of neurofibrillary tangle deposition.

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  • Authors+Show Affiliations

    ,

    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoprotein E4
    Brain
    Female
    Follow-Up Studies
    Humans
    Likelihood Functions
    Longitudinal Studies
    Male
    Middle Aged
    Neoplasms
    Neurofibrillary Tangles
    Odds Ratio
    Plaque, Amyloid
    Risk Factors
    tau Proteins

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    28035936

    Citation

    Yarchoan, Mark, et al. "Association of Cancer History With Alzheimer's Disease Dementia and Neuropathology." Journal of Alzheimer's Disease : JAD, vol. 56, no. 2, 2017, pp. 699-706.
    Yarchoan M, James BD, Shah RC, et al. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017;56(2):699-706.
    Yarchoan, M., James, B. D., Shah, R. C., Arvanitakis, Z., Wilson, R. S., Schneider, J., ... Arnold, S. E. (2017). Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. Journal of Alzheimer's Disease : JAD, 56(2), pp. 699-706. doi:10.3233/JAD-160977.
    Yarchoan M, et al. Association of Cancer History With Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017;56(2):699-706. PubMed PMID: 28035936.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. AU - Yarchoan,Mark, AU - James,Bryan D, AU - Shah,Raj C, AU - Arvanitakis,Zoe, AU - Wilson,Robert S, AU - Schneider,Julie, AU - Bennett,David A, AU - Arnold,Steven E, PY - 2016/12/31/pubmed PY - 2018/2/24/medline PY - 2016/12/31/entrez KW - Alzheimer’s disease KW - PHFtau KW - amyloid-β KW - cancer KW - cohort study KW - dementia KW - malignancy KW - neurofibrillary tangles SP - 699 EP - 706 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 56 IS - 2 N2 - BACKGROUND: Cancer and Alzheimer's disease (AD) are common diseases of aging and share many risk factors. Surprisingly, however, epidemiologic data from several recent independent cohort studies suggest that there may be an inverse association between these diseases. OBJECTIVE: To determine the relationship between history of cancer and odds of dementia proximate to death and neuropathological indices of AD. METHODS: Using data from two separate clinical-pathologic cohort studies of aging and AD, the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP), we compared odds of AD dementia proximate to death among participants with and without a history of cancer. We then examined the relation of history of cancer with measures of AD pathology at autopsy, i.e., paired helical filament tau (PHFtau) neurofibrillary tangles and amyloid-β load. RESULTS: Participants reporting a history of cancer had significantly lower odds of AD (OR 0.70 [0.55-0.89], p = 0.0040) proximate to death as compared to participants reporting no prior history of cancer. The results remained significant after adjusting for multiple risk factors including age, sex, race, education, and presence of an APOEɛ4 allele. At autopsy, participants with a history of cancer had significantly fewer PHFtau tangles (p < 0.001) than participants without a history of cancer, but similar levels of amyloid-β. CONCLUSIONS: Cancer survivors have reduced odds of developing AD and a lower burden of neurofibrillary tangle deposition. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/28035936/Association_of_Cancer_History_with_Alzheimer's_Disease_Dementia_and_Neuropathology_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-160977 DB - PRIME DP - Unbound Medicine ER -