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Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation.
Neurobiol Learn Mem. 2017 Jul; 142(Pt A):21-29.NL

Abstract

It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training. In some instances, where post-retrieval treatments induce a retention deficit (which would be suggestive of interference with reconsolidation), memory is rescued by simple passing of time or by repeated retention tests. We now report that post-training and post-retrieval inhibition of transcription and translation in dorsal striatum, a structure where both of these manipulations have not been studied, produce interference with consolidation and a transitory retention deficit, respectively. These results do not give support to the reconsolidation hypothesis and lead to the conclusion that the post-activation deficiencies are due to interference with retrieval of information.

Authors+Show Affiliations

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Qro 76230, Mexico. Electronic address: prado@unam.mx.Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Qro 76230, Mexico. Electronic address: acmedina@unam.mx.Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Qro 76230, Mexico. Electronic address: crismedi@gmail.com.Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Qro 76230, Mexico. Electronic address: ginaqui@unam.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28039087

Citation

Prado-Alcalá, Roberto A., et al. "Inhibition of Transcription and Translation in the Striatum After Memory Reactivation: Lack of Evidence of Reconsolidation." Neurobiology of Learning and Memory, vol. 142, no. Pt A, 2017, pp. 21-29.
Prado-Alcalá RA, Medina AC, Bello-Medina PC, et al. Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation. Neurobiol Learn Mem. 2017;142(Pt A):21-29.
Prado-Alcalá, R. A., Medina, A. C., Bello-Medina, P. C., & Quirarte, G. L. (2017). Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation. Neurobiology of Learning and Memory, 142(Pt A), 21-29. https://doi.org/10.1016/j.nlm.2016.12.018
Prado-Alcalá RA, et al. Inhibition of Transcription and Translation in the Striatum After Memory Reactivation: Lack of Evidence of Reconsolidation. Neurobiol Learn Mem. 2017;142(Pt A):21-29. PubMed PMID: 28039087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation. AU - Prado-Alcalá,Roberto A, AU - Medina,Andrea Cristina, AU - Bello-Medina,Paola C, AU - Quirarte,Gina L, Y1 - 2016/12/27/ PY - 2016/10/17/received PY - 2016/12/22/revised PY - 2016/12/24/accepted PY - 2017/1/1/pubmed PY - 2018/3/27/medline PY - 2017/1/1/entrez KW - Anisomycin KW - Avoidance learning KW - DRB KW - Memory retrieval KW - Reconsolidation KW - Striatum SP - 21 EP - 29 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 142 IS - Pt A N2 - It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training. In some instances, where post-retrieval treatments induce a retention deficit (which would be suggestive of interference with reconsolidation), memory is rescued by simple passing of time or by repeated retention tests. We now report that post-training and post-retrieval inhibition of transcription and translation in dorsal striatum, a structure where both of these manipulations have not been studied, produce interference with consolidation and a transitory retention deficit, respectively. These results do not give support to the reconsolidation hypothesis and lead to the conclusion that the post-activation deficiencies are due to interference with retrieval of information. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/28039087/Inhibition_of_transcription_and_translation_in_the_striatum_after_memory_reactivation:_Lack_of_evidence_of_reconsolidation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(16)30423-3 DB - PRIME DP - Unbound Medicine ER -