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PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET - Application to amyloid imaging with AV45-PET.
Neuroimage. 2017 02 15; 147:669-677.N

Abstract

Positron emission tomography (PET) allows detecting molecular brain changes in vivo. However, the accuracy of PET is limited by partial volume effects (PVE) that affects quantitative analysis and visual interpretation of the images. Although PVE-correction methods have been shown to effectively increase the correspondence of the measured signal with the true regional tracer uptake, these procedures are still not commonly applied, neither in clinical nor in research settings. Here, we present an implementation of well validated PVE-correction procedures as a SPM toolbox, PETPVE12, for automated processing. We demonstrate its utility by a comprehensive analysis of the effects of PVE-correction on amyloid-sensitive AV45-PET data from 85 patients with Alzheimer's disease (AD) and 179 cognitively normal (CN) elderly. Effects of PVE-correction on global cortical standard uptake value ratios (SUVR) and the power of diagnostic group separation were assessed for the region-wise geometric transfer matrix method (PVEc-GTM), as well as for the 3-compartmental voxel-wise "Müller-Gärtner" method (PVEc-MG). Both PVE-correction methods resulted in decreased global cortical SUVRs in the low to middle range of SUVR values, and in increased global cortical SUVRs at the high values. As a consequence, average SUVR of the CN group was reduced, whereas average SUVR of the AD group was increased by PVE-correction. These effects were also reflected in increased accuracies of group discrimination after PVEc-GTM (AUC=0.86) and PVEc-MG (AUC=0.89) compared to standard non-corrected SUVR (AUC=0.84). Voxel-wise analyses of PVEc-MG corrected data also demonstrated improved detection of regionally increased AV45 SUVR values in AD patients. These findings complement the growing evidence for a beneficial effect of PVE-correction in quantitative analysis of amyloid-sensitive PET data. The novel PETPVE12 toolbox significantly facilitates the application of PVE-correction, particularly within SPM-based processing pipelines. This is expected to foster the use of PVE-correction in brain PET for more widespread use. The toolbox is freely available at http://www.fil.ion.ucl.ac.uk/spm/ext/#PETPVE12.

Authors+Show Affiliations

German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany. Electronic address: gabriellbk@gmail.com.Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany. Electronic address: michel.grothe@dzne.de.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28039094

Citation

Gonzalez-Escamilla, Gabriel, et al. "PETPVE12: an SPM Toolbox for Partial Volume Effects Correction in Brain PET - Application to Amyloid Imaging With AV45-PET." NeuroImage, vol. 147, 2017, pp. 669-677.
Gonzalez-Escamilla G, Lange C, Teipel S, et al. PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET - Application to amyloid imaging with AV45-PET. Neuroimage. 2017;147:669-677.
Gonzalez-Escamilla, G., Lange, C., Teipel, S., Buchert, R., & Grothe, M. J. (2017). PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET - Application to amyloid imaging with AV45-PET. NeuroImage, 147, 669-677. https://doi.org/10.1016/j.neuroimage.2016.12.077
Gonzalez-Escamilla G, et al. PETPVE12: an SPM Toolbox for Partial Volume Effects Correction in Brain PET - Application to Amyloid Imaging With AV45-PET. Neuroimage. 2017 02 15;147:669-677. PubMed PMID: 28039094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET - Application to amyloid imaging with AV45-PET. AU - Gonzalez-Escamilla,Gabriel, AU - Lange,Catharina, AU - Teipel,Stefan, AU - Buchert,Ralph, AU - Grothe,Michel J, AU - ,, Y1 - 2016/12/28/ PY - 2016/09/23/received PY - 2016/12/23/revised PY - 2016/12/27/accepted PY - 2017/1/1/pubmed PY - 2018/2/23/medline PY - 2017/1/1/entrez KW - Alzheimer's disease KW - Amyloid imaging KW - MRI KW - PET KW - Partial Volume Effects correction SP - 669 EP - 677 JF - NeuroImage JO - Neuroimage VL - 147 N2 - Positron emission tomography (PET) allows detecting molecular brain changes in vivo. However, the accuracy of PET is limited by partial volume effects (PVE) that affects quantitative analysis and visual interpretation of the images. Although PVE-correction methods have been shown to effectively increase the correspondence of the measured signal with the true regional tracer uptake, these procedures are still not commonly applied, neither in clinical nor in research settings. Here, we present an implementation of well validated PVE-correction procedures as a SPM toolbox, PETPVE12, for automated processing. We demonstrate its utility by a comprehensive analysis of the effects of PVE-correction on amyloid-sensitive AV45-PET data from 85 patients with Alzheimer's disease (AD) and 179 cognitively normal (CN) elderly. Effects of PVE-correction on global cortical standard uptake value ratios (SUVR) and the power of diagnostic group separation were assessed for the region-wise geometric transfer matrix method (PVEc-GTM), as well as for the 3-compartmental voxel-wise "Müller-Gärtner" method (PVEc-MG). Both PVE-correction methods resulted in decreased global cortical SUVRs in the low to middle range of SUVR values, and in increased global cortical SUVRs at the high values. As a consequence, average SUVR of the CN group was reduced, whereas average SUVR of the AD group was increased by PVE-correction. These effects were also reflected in increased accuracies of group discrimination after PVEc-GTM (AUC=0.86) and PVEc-MG (AUC=0.89) compared to standard non-corrected SUVR (AUC=0.84). Voxel-wise analyses of PVEc-MG corrected data also demonstrated improved detection of regionally increased AV45 SUVR values in AD patients. These findings complement the growing evidence for a beneficial effect of PVE-correction in quantitative analysis of amyloid-sensitive PET data. The novel PETPVE12 toolbox significantly facilitates the application of PVE-correction, particularly within SPM-based processing pipelines. This is expected to foster the use of PVE-correction in brain PET for more widespread use. The toolbox is freely available at http://www.fil.ion.ucl.ac.uk/spm/ext/#PETPVE12. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/28039094/PETPVE12:_an_SPM_toolbox_for_Partial_Volume_Effects_correction_in_brain_PET___Application_to_amyloid_imaging_with_AV45_PET_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(16)30802-3 DB - PRIME DP - Unbound Medicine ER -