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Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma.
Oncotarget. 2017 Jan 31; 8(5):8315-8329.O

Abstract

Accumulating evidence has shown that PD-L1 expression is associated with clinicopathological features in various human malignancies. We searched for correlations between PD-L1 expression and clinicopathological data in esophageal squamous cell carcinoma (ESCC) patients. PD-L1 expression in primary tumors from 278 patients was evaluated using immunohistochemistry (IHC) in ESCC tissue microarray. Survival curves were constructed by using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Overall, tumoral PD-L1 expression (≥10%, 20% or 30% as cut-off value) was associated with favorable DFS and OS upon multivariate analysis. When the patients stratified into stage I-II (168, 60.4%) and stage III-IV (110, 39.6%), or with lymph node metastasis (133, 47.8%), the prognostic role was not consistent. In patients with stage I-II disease, tumoral PD-L1 expression (≥5%, 10%, 20% or 30%) was associated with better DFS and OS upon multivariate analysis. In patients without lymph node metastasis, tumoral PD-L1 expression (≥1%, 5%, 10%, 20%, or 30%) was associated with improved DFS and OS in univariate or multivariate analysis. However, PD-L1 expression was not correlated with prognosis in patients with stage III-IV disease or with lymph node metastasis. Our results for the first time showed the prognostic role of tumoral PD-L1 expression was variable in different stages and lymph node status of ESCC. Tumoral PD-L1 expression was independent favorable predictor in ESCC patients with Stage I-II disease or without lymph node metastasis, not in stage III-IV or lymph node metastasis.

Authors+Show Affiliations

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China. Department of Pathology, School of Basic Medical Sciences & Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28039448

Citation

Jiang, Dongxian, et al. "Independent Prognostic Role of PD-L1expression in Patients With Esophageal Squamous Cell Carcinoma." Oncotarget, vol. 8, no. 5, 2017, pp. 8315-8329.
Jiang D, Song Q, Wang H, et al. Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma. Oncotarget. 2017;8(5):8315-8329.
Jiang, D., Song, Q., Wang, H., Huang, J., Wang, H., Hou, J., Li, X., Xu, Y., Sujie, A., Zeng, H., Tan, L., & Hou, Y. (2017). Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma. Oncotarget, 8(5), 8315-8329. https://doi.org/10.18632/oncotarget.14174
Jiang D, et al. Independent Prognostic Role of PD-L1expression in Patients With Esophageal Squamous Cell Carcinoma. Oncotarget. 2017 Jan 31;8(5):8315-8329. PubMed PMID: 28039448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma. AU - Jiang,Dongxian, AU - Song,Qi, AU - Wang,Haixing, AU - Huang,Jie, AU - Wang,Hao, AU - Hou,Jun, AU - Li,Xiaojing, AU - Xu,Yifan, AU - Sujie,Akesu, AU - Zeng,Haiying, AU - Tan,Lijie, AU - Hou,Yingyong, PY - 2016/08/15/received PY - 2016/11/22/accepted PY - 2017/1/1/pubmed PY - 2018/2/27/medline PY - 2017/1/1/entrez KW - ESCC KW - PD-L1 expression KW - clinical stage KW - lymph node metastasis KW - prognostic marker SP - 8315 EP - 8329 JF - Oncotarget JO - Oncotarget VL - 8 IS - 5 N2 - Accumulating evidence has shown that PD-L1 expression is associated with clinicopathological features in various human malignancies. We searched for correlations between PD-L1 expression and clinicopathological data in esophageal squamous cell carcinoma (ESCC) patients. PD-L1 expression in primary tumors from 278 patients was evaluated using immunohistochemistry (IHC) in ESCC tissue microarray. Survival curves were constructed by using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Overall, tumoral PD-L1 expression (≥10%, 20% or 30% as cut-off value) was associated with favorable DFS and OS upon multivariate analysis. When the patients stratified into stage I-II (168, 60.4%) and stage III-IV (110, 39.6%), or with lymph node metastasis (133, 47.8%), the prognostic role was not consistent. In patients with stage I-II disease, tumoral PD-L1 expression (≥5%, 10%, 20% or 30%) was associated with better DFS and OS upon multivariate analysis. In patients without lymph node metastasis, tumoral PD-L1 expression (≥1%, 5%, 10%, 20%, or 30%) was associated with improved DFS and OS in univariate or multivariate analysis. However, PD-L1 expression was not correlated with prognosis in patients with stage III-IV disease or with lymph node metastasis. Our results for the first time showed the prognostic role of tumoral PD-L1 expression was variable in different stages and lymph node status of ESCC. Tumoral PD-L1 expression was independent favorable predictor in ESCC patients with Stage I-II disease or without lymph node metastasis, not in stage III-IV or lymph node metastasis. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/28039448/Independent_prognostic_role_of_PD_L1expression_in_patients_with_esophageal_squamous_cell_carcinoma_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=14174 DB - PRIME DP - Unbound Medicine ER -