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Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations.
Biomed Pharmacother. 2017 Mar; 87:27-36.BP

Abstract

In this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (α-glucosidase and α-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11±1.40mgGAE/g and 42.04±0.16mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34±3.33mgTE/g and 165.42±2.16mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals.

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Authors+Show Affiliations

Zengin G
Selcuk University, Science Faculty, Department of Biology, Campus, 42250, Konya, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr.
Uysal A
Department of Medicinal Laboratory, Vocational School of Health Services, Selcuk University, Konya, Turkey.
Aktumsek A
Selcuk University, Science Faculty, Department of Biology, Campus, 42250, Konya, Turkey.
Mocan A
Department of Pharmaceutical Botany, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania.
Mollica A
Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100, Chieti, Italy.
Locatelli M
Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100, Chieti, Italy.
Custodio L
Centre of Marine Sciences, Faculty of Sciences and Technology, Campus of Gambelas, University of Algarve, Faro, Portugal.
Neng NR
Faculty of Sciences of the University of Lisbon, Centre of Chemistry and Biochemistry/Department of Chemistry and Biochemistry, Building C8, Floor 5, Campo Grande, 1749-016 Lisbon, Portugal.
Nogueira JMF
Faculty of Sciences of the University of Lisbon, Centre of Chemistry and Biochemistry/Department of Chemistry and Biochemistry, Building C8, Floor 5, Campo Grande, 1749-016 Lisbon, Portugal.
Aumeeruddy-Elalfi Z
Department of Health Sciences, Faculty of Science, University of Mauritius, Mauritius.
Mahomoodally MF
Department of Health Sciences, Faculty of Science, University of Mauritius, Mauritius.

MeSH

Anti-Bacterial AgentsAntioxidantsDrug CompoundingEuphorbiaFlavonoidsMethicillin-Resistant Staphylococcus aureusMolecular Docking SimulationPhenolsPhytochemicalsPlant Components, AerialPlant Extracts

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28040595

Citation

Zengin, Gokhan, et al. "Euphorbia Denticulata Lam.: a Promising Source of Phyto-pharmaceuticals for the Development of Novel Functional Formulations." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 87, 2017, pp. 27-36.
Zengin G, Uysal A, Aktumsek A, et al. Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations. Biomed Pharmacother. 2017;87:27-36.
Zengin, G., Uysal, A., Aktumsek, A., Mocan, A., Mollica, A., Locatelli, M., Custodio, L., Neng, N. R., Nogueira, J. M. F., Aumeeruddy-Elalfi, Z., & Mahomoodally, M. F. (2017). Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 87, 27-36. https://doi.org/10.1016/j.biopha.2016.12.063
Zengin G, et al. Euphorbia Denticulata Lam.: a Promising Source of Phyto-pharmaceuticals for the Development of Novel Functional Formulations. Biomed Pharmacother. 2017;87:27-36. PubMed PMID: 28040595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations. AU - Zengin,Gokhan, AU - Uysal,Ahmet, AU - Aktumsek,Abdurrahman, AU - Mocan,Andrei, AU - Mollica,Adriano, AU - Locatelli,Marcello, AU - Custodio,Luisa, AU - Neng,Nuno R, AU - Nogueira,José M F, AU - Aumeeruddy-Elalfi,Zaahira, AU - Mahomoodally,M Fawzi, Y1 - 2016/12/29/ PY - 2016/10/11/received PY - 2016/12/12/revised PY - 2016/12/16/accepted PY - 2017/1/4/pubmed PY - 2017/2/22/medline PY - 2017/1/2/entrez KW - Diabetes KW - Euphorbia denticulata KW - Molecular docking KW - Phyto-pharmaceuticals KW - Polyphenols SP - 27 EP - 36 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 87 N2 - In this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (α-glucosidase and α-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11±1.40mgGAE/g and 42.04±0.16mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34±3.33mgTE/g and 165.42±2.16mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28040595/Euphorbia_denticulata_Lam_:_A_promising_source_of_phyto_pharmaceuticals_for_the_development_of_novel_functional_formulations_ DB - PRIME DP - Unbound Medicine ER -