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Changes in body composition in women using long-acting reversible contraception.
Contraception. 2017 Apr; 95(4):382-389.C

Abstract

OBJECTIVE

Users of hormonal long-acting reversible contraception (LARC) report weight gain as a side effect, but few studies have assessed body composition change among LARC users. We evaluated weight and body composition of healthy women using the levonorgestrel intrauterine system (LNG-IUS), copper intrauterine device (copper IUD) or etonogestrel implant (ENG implant). We hypothesized that weight gain and body composition over 12 months would not differ between copper IUD, LNG-IUS and ENG implant users.

STUDY DESIGN

We performed a prospective cohort study of a subgroup of women enrolled in the Contraceptive CHOICE Project who initiated the LNG-IUS, copper IUD or ENG implant. Inclusion criteria included lack of metabolic and eating disorders or change in body weight of more than 5% in the 6 months before enrollment. We measured changes in weight and body composition (body fat percentage, total body fat mass, total lean mass and total body mass) in women who continued their method for 12 months.

RESULTS

We analyzed data from 149 participants: 85 LNG-IUS users, 31 copper IUD users and 33 ENG implant users. The mean age was 25.9 years, 56.4% were White, 82.5% had some college education and 67.6% were nulliparous. Although lean body mass increased over 12 months in LNG-IUS and copper IUD users but not in ENG implant users, changes in body weight and body composition did not differ between the groups. In the adjusted model, Black race was associated with change in total body mass (p<.05).

CONCLUSIONS

Among those who continued the method for 12 months, changes in body weight and composition did not differ between copper IUD, LNG-IUS and ENG implant users.

IMPLICATIONS STATEMENT

Changes in body weight and composition over 12 months did not differ between copper IUD users and LNG-IUS and ENG implant users among those with 12 months of continuous use.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil; Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO. Electronic address: prisnssilva@gmail.com.Division of Family Planning, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28041992

Citation

Silva Dos Santos, Priscilla de Nazaré, et al. "Changes in Body Composition in Women Using Long-acting Reversible Contraception." Contraception, vol. 95, no. 4, 2017, pp. 382-389.
Silva Dos Santos PN, Madden T, Omvig K, et al. Changes in body composition in women using long-acting reversible contraception. Contraception. 2017;95(4):382-389.
Silva Dos Santos, P. N., Madden, T., Omvig, K., & Peipert, J. F. (2017). Changes in body composition in women using long-acting reversible contraception. Contraception, 95(4), 382-389. https://doi.org/10.1016/j.contraception.2016.12.006
Silva Dos Santos PN, et al. Changes in Body Composition in Women Using Long-acting Reversible Contraception. Contraception. 2017;95(4):382-389. PubMed PMID: 28041992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in body composition in women using long-acting reversible contraception. AU - Silva Dos Santos,Priscilla de Nazaré, AU - Madden,Tessa, AU - Omvig,Karen, AU - Peipert,Jeffrey F, Y1 - 2016/12/30/ PY - 2016/03/26/received PY - 2016/12/16/revised PY - 2016/12/27/accepted PY - 2017/1/4/pubmed PY - 2017/10/13/medline PY - 2017/1/3/entrez KW - Body composition KW - Contraception KW - Copper intrauterine device KW - Etonogestrel subdermal implant KW - Levonorgestrel intrauterine system KW - Weight SP - 382 EP - 389 JF - Contraception JO - Contraception VL - 95 IS - 4 N2 - OBJECTIVE: Users of hormonal long-acting reversible contraception (LARC) report weight gain as a side effect, but few studies have assessed body composition change among LARC users. We evaluated weight and body composition of healthy women using the levonorgestrel intrauterine system (LNG-IUS), copper intrauterine device (copper IUD) or etonogestrel implant (ENG implant). We hypothesized that weight gain and body composition over 12 months would not differ between copper IUD, LNG-IUS and ENG implant users. STUDY DESIGN: We performed a prospective cohort study of a subgroup of women enrolled in the Contraceptive CHOICE Project who initiated the LNG-IUS, copper IUD or ENG implant. Inclusion criteria included lack of metabolic and eating disorders or change in body weight of more than 5% in the 6 months before enrollment. We measured changes in weight and body composition (body fat percentage, total body fat mass, total lean mass and total body mass) in women who continued their method for 12 months. RESULTS: We analyzed data from 149 participants: 85 LNG-IUS users, 31 copper IUD users and 33 ENG implant users. The mean age was 25.9 years, 56.4% were White, 82.5% had some college education and 67.6% were nulliparous. Although lean body mass increased over 12 months in LNG-IUS and copper IUD users but not in ENG implant users, changes in body weight and body composition did not differ between the groups. In the adjusted model, Black race was associated with change in total body mass (p<.05). CONCLUSIONS: Among those who continued the method for 12 months, changes in body weight and composition did not differ between copper IUD, LNG-IUS and ENG implant users. IMPLICATIONS STATEMENT: Changes in body weight and composition over 12 months did not differ between copper IUD users and LNG-IUS and ENG implant users among those with 12 months of continuous use. SN - 1879-0518 UR - https://www.unboundmedicine.com/medline/citation/28041992/Changes_in_body_composition_in_women_using_long_acting_reversible_contraception_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(16)30544-3 DB - PRIME DP - Unbound Medicine ER -