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Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
Biomed Res Int. 2016; 2016:8212459.BR

Abstract

Objective.

The aim of this study was to investigate the association between COPD and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). Methods. 2,362 patients who underwent PCI were included in this study. Subjects were divided into 2 groups: with COPD (n = 233) and without COPD (n = 2,129). Cox proportional hazards models were analyzed to determine the effect of COPD on the incidence of MACCE.

Results.

The patients with COPD were older (P < 0.0001) and were more likely to be current smokers (P = 0.02) and have had hypertension (P = 0.02) and diabetes mellitus (P = 0.01). Prevalence of serious cardiovascular comorbidity was higher in the patients with COPD, including a history of MI (P = 0.02) and HF (P < 0.0001). Compared with non-COPD group, the COPD group showed a higher risk of all-cause death (hazard ratio (HR): 2.45, P < 0.0001), cardiac death (HR: 2.53, P = 0.0002), MI (HR: 1.387, P = 0.027), and HF (HR: 2.25, P < 0.0001).

Conclusions.

Patients with CAD and concomitant COPD are associated with a higher incidence of MACCE (all-cause death, cardiac death, MI, and HF) compared to patients without COPD. The patients with a history of COPD have higher in-hospital and long-term mortality rates than those without COPD after PCI.

Authors+Show Affiliations

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.Department of Cardiology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.Department of Cardiology, Provincial Clinical Medical College, Fujian Medical University, Fuzhou, China.Department of Endocrinology, Tongji Hospital, Tongji University, Shanghai 200065, China.Intensive Care Unit, Shenzhen People's Hospital, The Second Clinical Hospital of Jinan University, Guangzhou, China.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.Department of Biostatistics, School of Public Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.Department of Cardiology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28042573

Citation

Zhang, Ming, et al. "Impact of Chronic Obstructive Pulmonary Disease On Long-Term Outcome in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention." BioMed Research International, vol. 2016, 2016, p. 8212459.
Zhang M, Cheng YJ, Zheng WP, et al. Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Biomed Res Int. 2016;2016:8212459.
Zhang, M., Cheng, Y. J., Zheng, W. P., Liu, G. H., Chen, H. S., Ning, Y., Zhao, X., Su, L. X., & Liu, L. J. (2016). Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. BioMed Research International, 2016, 8212459. https://doi.org/10.1155/2016/8212459
Zhang M, et al. Impact of Chronic Obstructive Pulmonary Disease On Long-Term Outcome in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Biomed Res Int. 2016;2016:8212459. PubMed PMID: 28042573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. AU - Zhang,Ming, AU - Cheng,Yun-Jiu, AU - Zheng,Wei-Ping, AU - Liu,Guang-Hui, AU - Chen,Huai-Sheng, AU - Ning,Yu, AU - Zhao,Xin, AU - Su,Li-Xiao, AU - Liu,Li-Juan, Y1 - 2016/11/30/ PY - 2016/06/10/received PY - 2016/09/12/revised PY - 2016/09/28/accepted PY - 2017/1/3/entrez PY - 2017/1/4/pubmed PY - 2017/1/20/medline SP - 8212459 EP - 8212459 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - Objective. The aim of this study was to investigate the association between COPD and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). Methods. 2,362 patients who underwent PCI were included in this study. Subjects were divided into 2 groups: with COPD (n = 233) and without COPD (n = 2,129). Cox proportional hazards models were analyzed to determine the effect of COPD on the incidence of MACCE. Results. The patients with COPD were older (P < 0.0001) and were more likely to be current smokers (P = 0.02) and have had hypertension (P = 0.02) and diabetes mellitus (P = 0.01). Prevalence of serious cardiovascular comorbidity was higher in the patients with COPD, including a history of MI (P = 0.02) and HF (P < 0.0001). Compared with non-COPD group, the COPD group showed a higher risk of all-cause death (hazard ratio (HR): 2.45, P < 0.0001), cardiac death (HR: 2.53, P = 0.0002), MI (HR: 1.387, P = 0.027), and HF (HR: 2.25, P < 0.0001). Conclusions. Patients with CAD and concomitant COPD are associated with a higher incidence of MACCE (all-cause death, cardiac death, MI, and HF) compared to patients without COPD. The patients with a history of COPD have higher in-hospital and long-term mortality rates than those without COPD after PCI. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/28042573/Impact_of_Chronic_Obstructive_Pulmonary_Disease_on_Long_Term_Outcome_in_Patients_with_Coronary_Artery_Disease_Undergoing_Percutaneous_Coronary_Intervention_ L2 - https://dx.doi.org/10.1155/2016/8212459 DB - PRIME DP - Unbound Medicine ER -