Tags

Type your tag names separated by a space and hit enter

Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia.
J Coll Physicians Surg Pak. 2016 Dec; 26(12):992-994.JC

Abstract

Hepatitis B virus (HBV) typically causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. It is associated with a variety of extrahepatic complications. We herein, present a rare extrahepatic complication of HBV infection. A 32-year man presented with melena, bleeding from gums and fever. Peripheral blood examination revealed anemia, macrocytosis and severe thrombocytopenia. His hepatitis B surface antigen (HBsAg) was positive but deoxyribonucleic acid (HBV DNA) by polymerase chain reaction (PCR) was negative. Other hepatitis, human immune deficiency virus (HIV), dengue, and autoimmune serology were negative. Bone marrow examination revealed megaloblastic erythropoiesis. There was mild to moderate reduction of megakaryocytes in bone marrow, which was not compatible with severe peripheral thrombocytopenia. His response to cyanocobalamin and folic acid was remarkable for myeloid cell lines and moderate for erythroid cell lines, but poor to platelet counts. Platelet counts gradually improved to safe limits with eltrombopag, likely reflecting autoimmune pathogenesis for thrombocytopenia. This case report highlights multiple targets of HBV infection with associated multiple pathogenetic mechanisms.

Authors+Show Affiliations

Department of Gastroenterology, Combined Military Hospital, Kharian.Department of Pathology, Combined Military Hospital, Kharian.Department of Medicine, Combined Military Hospital, Kharian.Department of Ophthalmology, Combined Military Hospital, Kharian.Department of Cardiology, Combined Military Hospital, Kharian.Department of Haematology, Combined Military Hospital, Kharian.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28043314

Citation

Hafeez, Muhammad, et al. "Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 26, no. 12, 2016, pp. 992-994.
Hafeez M, Sarfraz T, Khan RG, et al. Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia. J Coll Physicians Surg Pak. 2016;26(12):992-994.
Hafeez, M., Sarfraz, T., Khan, R. G., Rafe, A., Rasool, G., & Ahmed, K. N. (2016). Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 26(12), 992-994. https://doi.org/2502
Hafeez M, et al. Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia. J Coll Physicians Surg Pak. 2016;26(12):992-994. PubMed PMID: 28043314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B Leading to Megaloblastic Anemia and Catastrophic Peripheral Thrombocytopenia. AU - Hafeez,Muhammad, AU - Sarfraz,Tariq, AU - Khan,Raja Ghayas, AU - Rafe,Abdul, AU - Rasool,Ghulam, AU - Ahmed,Kamran Nazir, PY - 2017/01/18/received PY - 2016/10/22/accepted PY - 2017/1/4/entrez PY - 2017/1/4/pubmed PY - 2017/7/1/medline SP - 992 EP - 994 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 26 IS - 12 N2 - Hepatitis B virus (HBV) typically causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. It is associated with a variety of extrahepatic complications. We herein, present a rare extrahepatic complication of HBV infection. A 32-year man presented with melena, bleeding from gums and fever. Peripheral blood examination revealed anemia, macrocytosis and severe thrombocytopenia. His hepatitis B surface antigen (HBsAg) was positive but deoxyribonucleic acid (HBV DNA) by polymerase chain reaction (PCR) was negative. Other hepatitis, human immune deficiency virus (HIV), dengue, and autoimmune serology were negative. Bone marrow examination revealed megaloblastic erythropoiesis. There was mild to moderate reduction of megakaryocytes in bone marrow, which was not compatible with severe peripheral thrombocytopenia. His response to cyanocobalamin and folic acid was remarkable for myeloid cell lines and moderate for erythroid cell lines, but poor to platelet counts. Platelet counts gradually improved to safe limits with eltrombopag, likely reflecting autoimmune pathogenesis for thrombocytopenia. This case report highlights multiple targets of HBV infection with associated multiple pathogenetic mechanisms. SN - 1681-7168 UR - https://www.unboundmedicine.com/medline/citation/28043314/Hepatitis_B_Leading_to_Megaloblastic_Anemia_and_Catastrophic_Peripheral_Thrombocytopenia_ L2 - http://www.diseaseinfosearch.org/result/4562 DB - PRIME DP - Unbound Medicine ER -