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Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease.
CNS Neurosci Ther. 2017 Mar; 23(3):241-247.CN

Abstract

AIMS

Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood. This study aimed at investigating the neural substrates of fatigue in patients with PD.

METHODS

A total of 17 PD patients with fatigue, 32 PD patients without fatigue, and 25 matched healthy controls were recruited. The 9-item fatigue severity scale (FSS) was used for fatigue screening and severity rating. Resting-state functional magnetic resonance imaging (RS-fMRI) data were obtained from all subjects. Amplitude of low-frequency fluctuations (ALFF) was used to measure regional brain activity, and functional connectivity (FC) was applied to investigate functional connectivity at a network level.

RESULTS

PD-related fatigue was associated with ALFF changes in right middle frontal gyrus within the attention network and in left insula as well as right midcingulate cortex within the salience network. FC analysis revealed that above three regions showing ALFF differences had altered functional connectivity mainly in the temporal, parietal, and motor cortices.

CONCLUSION

Our findings do reveal that abnormal regional brain activity within attention and salience network and altered FC of above abnormal regions are involved in neural mechanism of fatigue in patients with PD.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28044431

Citation

Zhang, Jie-Jin, et al. "Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease." CNS Neuroscience & Therapeutics, vol. 23, no. 3, 2017, pp. 241-247.
Zhang JJ, Ding J, Li JY, et al. Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease. CNS Neurosci Ther. 2017;23(3):241-247.
Zhang, J. J., Ding, J., Li, J. Y., Wang, M., Yuan, Y. S., Zhang, L., Jiang, S. M., Wang, X. X., Zhu, L., & Zhang, K. Z. (2017). Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease. CNS Neuroscience & Therapeutics, 23(3), 241-247. https://doi.org/10.1111/cns.12666
Zhang JJ, et al. Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease. CNS Neurosci Ther. 2017;23(3):241-247. PubMed PMID: 28044431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease. AU - Zhang,Jie-Jin, AU - Ding,Jian, AU - Li,Jun-Yi, AU - Wang,Min, AU - Yuan,Yong-Sheng, AU - Zhang,Li, AU - Jiang,Si-Ming, AU - Wang,Xi-Xi, AU - Zhu,Lin, AU - Zhang,Ke-Zhong, Y1 - 2017/01/03/ PY - 2016/09/10/received PY - 2016/11/28/revised PY - 2016/11/29/accepted PY - 2017/1/4/pubmed PY - 2017/10/20/medline PY - 2017/1/4/entrez KW - Amplitude of low-frequency fluctuations KW - Fatigue KW - Functional connectivity KW - Parkinson's disease SP - 241 EP - 247 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 23 IS - 3 N2 - AIMS: Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood. This study aimed at investigating the neural substrates of fatigue in patients with PD. METHODS: A total of 17 PD patients with fatigue, 32 PD patients without fatigue, and 25 matched healthy controls were recruited. The 9-item fatigue severity scale (FSS) was used for fatigue screening and severity rating. Resting-state functional magnetic resonance imaging (RS-fMRI) data were obtained from all subjects. Amplitude of low-frequency fluctuations (ALFF) was used to measure regional brain activity, and functional connectivity (FC) was applied to investigate functional connectivity at a network level. RESULTS: PD-related fatigue was associated with ALFF changes in right middle frontal gyrus within the attention network and in left insula as well as right midcingulate cortex within the salience network. FC analysis revealed that above three regions showing ALFF differences had altered functional connectivity mainly in the temporal, parietal, and motor cortices. CONCLUSION: Our findings do reveal that abnormal regional brain activity within attention and salience network and altered FC of above abnormal regions are involved in neural mechanism of fatigue in patients with PD. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/28044431/Abnormal_Resting_State_Neural_Activity_and_Connectivity_of_Fatigue_in_Parkinson's_Disease_ L2 - https://doi.org/10.1111/cns.12666 DB - PRIME DP - Unbound Medicine ER -