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Failure of Autologous Chondrocyte Implantation.

Abstract

Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation. Failures are very heterogenously defined in the current literature. A widely accepted definition is needed, and a comprehensive definition taking into consideration the patient's perception of the outcome, not just the surgeon's or researcher's point of view, would be advisable. Finally, there is no agreement on the most appropriate treatment of failures, and further studies are needed to give better indications to properly manage patients failed after cartilage procedures.

LEVEL OF EVIDENCE

Level IV.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    †Nano-Biotechnology Laboratory *I Orthopaedic and Traumatologic Clinic Rizzoli Orthopaedic Institute, Bologna, Italy.

    , , ,

    Source

    MeSH

    Cartilage, Articular
    Chondrocytes
    Cumulative Trauma Disorders
    Humans
    Knee Injuries
    Orthopedic Procedures
    Reoperation
    Transplantation, Autologous
    Treatment Failure

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28045868

    Citation

    TY - JOUR T1 - Failure of Autologous Chondrocyte Implantation. AU - Andriolo,Luca, AU - Merli,Giulia, AU - Filardo,Giuseppe, AU - Marcacci,Maurilio, AU - Kon,Elizaveta, PY - 2017/1/4/entrez PY - 2017/1/4/pubmed PY - 2017/6/16/medline SP - 10 EP - 18 JF - Sports medicine and arthroscopy review JO - Sports Med Arthrosc VL - 25 IS - 1 N2 - : Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation. Failures are very heterogenously defined in the current literature. A widely accepted definition is needed, and a comprehensive definition taking into consideration the patient's perception of the outcome, not just the surgeon's or researcher's point of view, would be advisable. Finally, there is no agreement on the most appropriate treatment of failures, and further studies are needed to give better indications to properly manage patients failed after cartilage procedures. LEVEL OF EVIDENCE: Level IV. SN - 1538-1951 UR - https://www.unboundmedicine.com/medline/citation/28045868/Failure_of_Autologous_Chondrocyte_Implantation L2 - http://Insights.ovid.com/pubmed?pmid=28045868 ER -