Tags

Type your tag names separated by a space and hit enter

Failure of Autologous Chondrocyte Implantation.
Sports Med Arthrosc Rev 2017; 25(1):10-18SM

Abstract

Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation. Failures are very heterogenously defined in the current literature. A widely accepted definition is needed, and a comprehensive definition taking into consideration the patient's perception of the outcome, not just the surgeon's or researcher's point of view, would be advisable. Finally, there is no agreement on the most appropriate treatment of failures, and further studies are needed to give better indications to properly manage patients failed after cartilage procedures.

LEVEL OF EVIDENCE

Level IV.

Authors+Show Affiliations

†Nano-Biotechnology Laboratory *I Orthopaedic and Traumatologic Clinic Rizzoli Orthopaedic Institute, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

28045868

Citation

Andriolo, Luca, et al. "Failure of Autologous Chondrocyte Implantation." Sports Medicine and Arthroscopy Review, vol. 25, no. 1, 2017, pp. 10-18.
Andriolo L, Merli G, Filardo G, et al. Failure of Autologous Chondrocyte Implantation. Sports Med Arthrosc Rev. 2017;25(1):10-18.
Andriolo, L., Merli, G., Filardo, G., Marcacci, M., & Kon, E. (2017). Failure of Autologous Chondrocyte Implantation. Sports Medicine and Arthroscopy Review, 25(1), pp. 10-18. doi:10.1097/JSA.0000000000000137.
Andriolo L, et al. Failure of Autologous Chondrocyte Implantation. Sports Med Arthrosc Rev. 2017;25(1):10-18. PubMed PMID: 28045868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Failure of Autologous Chondrocyte Implantation. AU - Andriolo,Luca, AU - Merli,Giulia, AU - Filardo,Giuseppe, AU - Marcacci,Maurilio, AU - Kon,Elizaveta, PY - 2017/1/4/entrez PY - 2017/1/4/pubmed PY - 2017/6/16/medline SP - 10 EP - 18 JF - Sports medicine and arthroscopy review JO - Sports Med Arthrosc Rev VL - 25 IS - 1 N2 - : Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation. Failures are very heterogenously defined in the current literature. A widely accepted definition is needed, and a comprehensive definition taking into consideration the patient's perception of the outcome, not just the surgeon's or researcher's point of view, would be advisable. Finally, there is no agreement on the most appropriate treatment of failures, and further studies are needed to give better indications to properly manage patients failed after cartilage procedures. LEVEL OF EVIDENCE: Level IV. SN - 1538-1951 UR - https://www.unboundmedicine.com/medline/citation/28045868/Failure_of_Autologous_Chondrocyte_Implantation L2 - http://Insights.ovid.com/pubmed?pmid=28045868 DB - PRIME DP - Unbound Medicine ER -