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Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study.
J Korean Med Sci. 2017 Feb; 32(2):257-263.JK

Abstract

Adverse changes in nutrition are prevalent and are strong indicators of adverse outcomes in patients with chronic kidney disease (CKD). The International Society of Renal Nutrition and Metabolism (ISRNM) proposed a common nomenclature and diagnostic criteria to identify protein-energy wasting (PEW) in CKD patients. We examined the nutritional status in 1,834 adults with predialysis CKD enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) study. As there was a need for further understanding of nutritional status and associated factors in CKD, we evaluated the prevalence and associated factors of PEW in adults with predialysis CKD. The prevalence of PEW was about 9.0% according to ISRNM criteria and tended to increase with advanced stage in predialysis CKD. Those who concurrently had PEW, inflammation, and CVD were a small proportion (0.4%). In multivariate logistic regression model, PEW was independently associated with estimated glomerular filtration rate (eGFR) (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.96-0.99), total CO₂ (OR, 0.93; 95% CI, 0.87-0.99), physical activity (OR, 0.43; 95% CI, 0.26-0.69), comorbid diabetes (OR, 1.68; 95% CI, 1.09-2.59), and high sensitivity C-reactive protein (hs-CRP) (OR, 1.03; 95% CI, 1.01-1.06). Our study suggests that PEW increases with advanced CKD stage. PEW is independently associated with renal function, low total CO₂, low physical activity, comorbid diabetes, and increased hs-CRP in adults with predialysis CKD.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. kyubeck.lee@samsung.com.Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Department of Internal Medicine, Inje University Pusan Paik Hospital, Busan, Korea.Department of Internal Medicine, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Korea.Department of Internal Medicine, Eulji General Hospital, Eulji University, Seoul, Korea.Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28049236

Citation

Hyun, Young Youl, et al. "Nutritional Status in Adults With Predialysis Chronic Kidney Disease: KNOW-CKD Study." Journal of Korean Medical Science, vol. 32, no. 2, 2017, pp. 257-263.
Hyun YY, Lee KB, Han SH, et al. Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study. J Korean Med Sci. 2017;32(2):257-263.
Hyun, Y. Y., Lee, K. B., Han, S. H., Kim, Y. H., Kim, Y. S., Lee, S. W., Oh, Y. K., Chae, D. W., & Ahn, C. (2017). Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study. Journal of Korean Medical Science, 32(2), 257-263. https://doi.org/10.3346/jkms.2017.32.2.257
Hyun YY, et al. Nutritional Status in Adults With Predialysis Chronic Kidney Disease: KNOW-CKD Study. J Korean Med Sci. 2017;32(2):257-263. PubMed PMID: 28049236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study. AU - Hyun,Young Youl, AU - Lee,Kyu Beck, AU - Han,Seung Hyeok, AU - Kim,Yeong Hoon, AU - Kim,Yong Soo, AU - Lee,Sung Woo, AU - Oh,Yun Kyu, AU - Chae,Dong Wan, AU - Ahn,Curie, PY - 2016/09/22/received PY - 2016/11/14/accepted PY - 2017/1/4/entrez PY - 2017/1/4/pubmed PY - 2017/4/1/medline KW - Chronic Kidney Disease KW - Inflammation KW - Nutrition KW - Protein-Energy Wasting SP - 257 EP - 263 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 32 IS - 2 N2 - Adverse changes in nutrition are prevalent and are strong indicators of adverse outcomes in patients with chronic kidney disease (CKD). The International Society of Renal Nutrition and Metabolism (ISRNM) proposed a common nomenclature and diagnostic criteria to identify protein-energy wasting (PEW) in CKD patients. We examined the nutritional status in 1,834 adults with predialysis CKD enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) study. As there was a need for further understanding of nutritional status and associated factors in CKD, we evaluated the prevalence and associated factors of PEW in adults with predialysis CKD. The prevalence of PEW was about 9.0% according to ISRNM criteria and tended to increase with advanced stage in predialysis CKD. Those who concurrently had PEW, inflammation, and CVD were a small proportion (0.4%). In multivariate logistic regression model, PEW was independently associated with estimated glomerular filtration rate (eGFR) (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.96-0.99), total CO₂ (OR, 0.93; 95% CI, 0.87-0.99), physical activity (OR, 0.43; 95% CI, 0.26-0.69), comorbid diabetes (OR, 1.68; 95% CI, 1.09-2.59), and high sensitivity C-reactive protein (hs-CRP) (OR, 1.03; 95% CI, 1.01-1.06). Our study suggests that PEW increases with advanced CKD stage. PEW is independently associated with renal function, low total CO₂, low physical activity, comorbid diabetes, and increased hs-CRP in adults with predialysis CKD. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/28049236/Nutritional_Status_in_Adults_with_Predialysis_Chronic_Kidney_Disease:_KNOW_CKD_Study_ DB - PRIME DP - Unbound Medicine ER -