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Dietary fiber intake is inversely associated with risk of pancreatic cancer: a meta-analysis.
Asia Pac J Clin Nutr 2017; 26(1):89-96AP

Abstract

BACKGROUND AND OBJECTIVES

The association between fiber intake and pancreatic cancer risk is conflicting and poorly explored. The aim of study was to investigate the association between dietary fiber intake and the risk of pancreatic cancer by conducting a meta-analysis of epidemiological studies.

METHODS AND STUDY DESIGN

Systematic search of PubMed and Embase databases up to April 2015 were conducted to identify relevant studies. Adjusted odds ratios (ORs) were combined using random-effects models to assess the risk of pancreatic cancer when comparing extreme categories of fiber intake. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for at least 3 exposure levels.

RESULTS

One cohort and thirteen case-control studies were identified. The overall analysis revealed a strong inverse association between risk of pancreatic cancer and high fiber intake (OR 0.52; 95% CI 0.44-0.61). No publication bias was detected by Egger's or Begg's test. The dose-response analyses showed that the summary OR for an increment of 10 g daily intake of fiber was 0.88 (0.84 to 0.92).

CONCLUSION

A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer. Further well-designed prospective studies are warranted to confirm the inverse association and to identify the dietary fiber types involved.

Authors+Show Affiliations

Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Email: uromao@126.com.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28049267

Citation

Mao, Qi-Qi, et al. "Dietary Fiber Intake Is Inversely Associated With Risk of Pancreatic Cancer: a Meta-analysis." Asia Pacific Journal of Clinical Nutrition, vol. 26, no. 1, 2017, pp. 89-96.
Mao QQ, Lin YW, Chen H, et al. Dietary fiber intake is inversely associated with risk of pancreatic cancer: a meta-analysis. Asia Pac J Clin Nutr. 2017;26(1):89-96.
Mao, Q. Q., Lin, Y. W., Chen, H., Qin, J., Zheng, X. Y., Xu, X., & Xie, L. P. (2017). Dietary fiber intake is inversely associated with risk of pancreatic cancer: a meta-analysis. Asia Pacific Journal of Clinical Nutrition, 26(1), pp. 89-96. doi:10.6133/apjcn.102015.03.
Mao QQ, et al. Dietary Fiber Intake Is Inversely Associated With Risk of Pancreatic Cancer: a Meta-analysis. Asia Pac J Clin Nutr. 2017;26(1):89-96. PubMed PMID: 28049267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber intake is inversely associated with risk of pancreatic cancer: a meta-analysis. AU - Mao,Qi-Qi, AU - Lin,Yi-Wei, AU - Chen,Hong, AU - Qin,Jie, AU - Zheng,Xiang-Yi, AU - Xu,Xin, AU - Xie,Li-Ping, PY - 2017/1/4/entrez PY - 2017/1/5/pubmed PY - 2017/6/14/medline SP - 89 EP - 96 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 26 IS - 1 N2 - BACKGROUND AND OBJECTIVES: The association between fiber intake and pancreatic cancer risk is conflicting and poorly explored. The aim of study was to investigate the association between dietary fiber intake and the risk of pancreatic cancer by conducting a meta-analysis of epidemiological studies. METHODS AND STUDY DESIGN: Systematic search of PubMed and Embase databases up to April 2015 were conducted to identify relevant studies. Adjusted odds ratios (ORs) were combined using random-effects models to assess the risk of pancreatic cancer when comparing extreme categories of fiber intake. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for at least 3 exposure levels. RESULTS: One cohort and thirteen case-control studies were identified. The overall analysis revealed a strong inverse association between risk of pancreatic cancer and high fiber intake (OR 0.52; 95% CI 0.44-0.61). No publication bias was detected by Egger's or Begg's test. The dose-response analyses showed that the summary OR for an increment of 10 g daily intake of fiber was 0.88 (0.84 to 0.92). CONCLUSION: A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer. Further well-designed prospective studies are warranted to confirm the inverse association and to identify the dietary fiber types involved. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/28049267/Dietary_fiber_intake_is_inversely_associated_with_risk_of_pancreatic_cancer:_a_meta_analysis_ L2 - http://apjcn.nhri.org.tw/server/APJCN/26/1/89.pdf DB - PRIME DP - Unbound Medicine ER -