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Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture with the Extended Biotic Ligand Model.
Arch Environ Contam Toxicol. 2017 Feb; 72(2):312-319.AE

Abstract

Metals are always found in the environment as mixtures rather than as solitary elements. Only a limited number of studies have developed appropriate models that incorporate bioavailability to estimate the toxicity of heavy-metal mixtures. In the present study, we explored the applicability of two extended biotic ligand model (BLM) approaches-BLM-f mix and BLM-toxicity unit (TU)-to predict and interpret mixture toxicity with the assumption that interactions between metal ions obey the BLM theory. Exposure assays of single and mixed metals were performed with inoculums of an ammonia-oxidizing bacterium SD5 isolated from soil. Nitrification of the cultures was the end point used to quantify the toxic response. The results indicated that the developed BLM-f mix approach could well estimate the single toxicity of Cu2+ and Zn2+ as well as their binary mixture toxicity to nitrification with >90% of toxicity variation explained. Assuming that metal ions compete with each other for binding at a single biotic ligand, the BLM-f mix approach (root-mean-square error [RMSE] = 19.66, R 2 = 0.8879) showed better predictive power than the BLM-TU approach (RMSE = 31.12, R 2 = 0.6892). The present study supports the use of the accumulation of metal ions at the biotic ligands as predictor of toxicity of single metals and metal mixtures.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Liu A
Shandong University of Technology, Zibo, 255049, China.
Li J
Shandong University of Technology, Zibo, 255049, China.
Li M
Shandong University of Technology, Zibo, 255049, China.
Niu XY
Shandong University of Technology, Zibo, 255049, China.
Wang J
Key Laboratory of Agriculture Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, China. jwang@sdau.edu.cn.

MeSH

CopperEnvironmental MonitoringLigandsModels, ChemicalNitrificationSoil MicrobiologySoil PollutantsZinc

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28050624

Citation

Liu, Aiju, et al. "Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture With the Extended Biotic Ligand Model." Archives of Environmental Contamination and Toxicology, vol. 72, no. 2, 2017, pp. 312-319.
Liu A, Li J, Li M, et al. Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture with the Extended Biotic Ligand Model. Arch Environ Contam Toxicol. 2017;72(2):312-319.
Liu, A., Li, J., Li, M., Niu, X. Y., & Wang, J. (2017). Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture with the Extended Biotic Ligand Model. Archives of Environmental Contamination and Toxicology, 72(2), 312-319. https://doi.org/10.1007/s00244-016-0346-9
Liu A, et al. Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture With the Extended Biotic Ligand Model. Arch Environ Contam Toxicol. 2017;72(2):312-319. PubMed PMID: 28050624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity Assessment of Binary Metal Mixtures (Copper-Zinc) to Nitrification in Soilless Culture with the Extended Biotic Ligand Model. AU - Liu,Aiju, AU - Li,JinXin, AU - Li,Menghong, AU - Niu,Xiao Yin, AU - Wang,Jun, Y1 - 2017/01/03/ PY - 2016/08/21/received PY - 2016/12/12/accepted PY - 2017/1/5/pubmed PY - 2017/2/9/medline PY - 2017/1/5/entrez SP - 312 EP - 319 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 72 IS - 2 N2 - Metals are always found in the environment as mixtures rather than as solitary elements. Only a limited number of studies have developed appropriate models that incorporate bioavailability to estimate the toxicity of heavy-metal mixtures. In the present study, we explored the applicability of two extended biotic ligand model (BLM) approaches-BLM-f mix and BLM-toxicity unit (TU)-to predict and interpret mixture toxicity with the assumption that interactions between metal ions obey the BLM theory. Exposure assays of single and mixed metals were performed with inoculums of an ammonia-oxidizing bacterium SD5 isolated from soil. Nitrification of the cultures was the end point used to quantify the toxic response. The results indicated that the developed BLM-f mix approach could well estimate the single toxicity of Cu2+ and Zn2+ as well as their binary mixture toxicity to nitrification with >90% of toxicity variation explained. Assuming that metal ions compete with each other for binding at a single biotic ligand, the BLM-f mix approach (root-mean-square error [RMSE] = 19.66, R 2 = 0.8879) showed better predictive power than the BLM-TU approach (RMSE = 31.12, R 2 = 0.6892). The present study supports the use of the accumulation of metal ions at the biotic ligands as predictor of toxicity of single metals and metal mixtures. SN - 1432-0703 UR - https://www.unboundmedicine.com/medline/citation/28050624/Toxicity_Assessment_of_Binary_Metal_Mixtures__Copper_Zinc__to_Nitrification_in_Soilless_Culture_with_the_Extended_Biotic_Ligand_Model_ DB - PRIME DP - Unbound Medicine ER -