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Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece.
Eur Child Adolesc Psychiatry. 2017 Jun; 26(6):703-714.EC

Abstract

Studies have suggested an association between maternal obesity pre-pregnancy and gestational diabetes (GDM) with impaired offspring neurodevelopment, but it is not clear if these associations are explained by shared familiar characteristics. We aimed to assess the associations of maternal and paternal obesity, maternal glucose intolerance in early pregnancy and GDM, with offspring neurodevelopment at 4 years of age. We included 772 mother-child pairs from the "Rhea" Mother-Child cohort in Crete, Greece. Data on maternal/paternal body mass index (BMI) and maternal fasting serum samples for glucose and insulin measurements were collected at 12 weeks of gestation. GDM screening was performed at 24-28 weeks. Neurodevelopment at 4 years was assessed using the McCarthy Scales of Children's Abilities. Behavioral difficulties were assessed by Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Multivariate linear regression analyses showed that maternal obesity was associated with a significant score reduction in general cognitive ability (β-coeff -4.03, 95% CI: -7.08, -0.97), perceptual performance (β-coeff -4.60, 95% CI: -7.74, -1.47), quantitative ability (β-coeff -4.43, 95% CI: -7.68, -1.18), and executive functions (β-coeff -4.92, 95% CI: -8.06, -1.78) at 4 years of age, after adjustment for several confounders and paternal BMI. Maternal obesity was also associated with increased behavioral difficulties (β-coeff 1.22, 95% CI: 0.09, 2.34) and ADHD symptoms (β-coeff 4.28, 95% CI: 1.20, 7.36) at preschool age. Paternal obesity maternal glucose intolerance in early pregnancy and GDM was not associated with child neurodevelopment. These findings suggest that maternal obesity may impair optimal child neurodevelopment at preschool age independently of family shared characteristics.

Authors+Show Affiliations

Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece. darvas72@yahoo.gr. Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital of Crete, Heraklion, Crete, Greece. darvas72@yahoo.gr.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece.Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital of Crete, Heraklion, Crete, Greece.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece. Department of Genetics and Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 40, PO Box 616, 6229 ER, Maastricht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28050707

Citation

Daraki, Vasiliki, et al. "Effect of Parental Obesity and Gestational Diabetes On Child Neuropsychological and Behavioral Development at 4 Years of Age: the Rhea Mother-child Cohort, Crete, Greece." European Child & Adolescent Psychiatry, vol. 26, no. 6, 2017, pp. 703-714.
Daraki V, Roumeliotaki T, Koutra K, et al. Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece. Eur Child Adolesc Psychiatry. 2017;26(6):703-714.
Daraki, V., Roumeliotaki, T., Koutra, K., Georgiou, V., Kampouri, M., Kyriklaki, A., Vafeiadi, M., Papavasiliou, S., Kogevinas, M., & Chatzi, L. (2017). Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece. European Child & Adolescent Psychiatry, 26(6), 703-714. https://doi.org/10.1007/s00787-016-0934-2
Daraki V, et al. Effect of Parental Obesity and Gestational Diabetes On Child Neuropsychological and Behavioral Development at 4 Years of Age: the Rhea Mother-child Cohort, Crete, Greece. Eur Child Adolesc Psychiatry. 2017;26(6):703-714. PubMed PMID: 28050707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece. AU - Daraki,Vasiliki, AU - Roumeliotaki,Theano, AU - Koutra,Katerina, AU - Georgiou,Vaggelis, AU - Kampouri,Mariza, AU - Kyriklaki,Andriani, AU - Vafeiadi,Marina, AU - Papavasiliou,Stathis, AU - Kogevinas,Manolis, AU - Chatzi,Leda, Y1 - 2017/01/03/ PY - 2016/08/09/received PY - 2016/12/16/accepted PY - 2017/1/5/pubmed PY - 2017/12/9/medline PY - 2017/1/5/entrez KW - Behavior KW - Gestational diabetes KW - Longitudinal study KW - Neuropsychological development KW - Obesity KW - Preschool age SP - 703 EP - 714 JF - European child & adolescent psychiatry JO - Eur Child Adolesc Psychiatry VL - 26 IS - 6 N2 - Studies have suggested an association between maternal obesity pre-pregnancy and gestational diabetes (GDM) with impaired offspring neurodevelopment, but it is not clear if these associations are explained by shared familiar characteristics. We aimed to assess the associations of maternal and paternal obesity, maternal glucose intolerance in early pregnancy and GDM, with offspring neurodevelopment at 4 years of age. We included 772 mother-child pairs from the "Rhea" Mother-Child cohort in Crete, Greece. Data on maternal/paternal body mass index (BMI) and maternal fasting serum samples for glucose and insulin measurements were collected at 12 weeks of gestation. GDM screening was performed at 24-28 weeks. Neurodevelopment at 4 years was assessed using the McCarthy Scales of Children's Abilities. Behavioral difficulties were assessed by Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Multivariate linear regression analyses showed that maternal obesity was associated with a significant score reduction in general cognitive ability (β-coeff -4.03, 95% CI: -7.08, -0.97), perceptual performance (β-coeff -4.60, 95% CI: -7.74, -1.47), quantitative ability (β-coeff -4.43, 95% CI: -7.68, -1.18), and executive functions (β-coeff -4.92, 95% CI: -8.06, -1.78) at 4 years of age, after adjustment for several confounders and paternal BMI. Maternal obesity was also associated with increased behavioral difficulties (β-coeff 1.22, 95% CI: 0.09, 2.34) and ADHD symptoms (β-coeff 4.28, 95% CI: 1.20, 7.36) at preschool age. Paternal obesity maternal glucose intolerance in early pregnancy and GDM was not associated with child neurodevelopment. These findings suggest that maternal obesity may impair optimal child neurodevelopment at preschool age independently of family shared characteristics. SN - 1435-165X UR - https://www.unboundmedicine.com/medline/citation/28050707/Effect_of_parental_obesity_and_gestational_diabetes_on_child_neuropsychological_and_behavioral_development_at_4_years_of_age:_the_Rhea_mother_child_cohort_Crete_Greece_ L2 - https://dx.doi.org/10.1007/s00787-016-0934-2 DB - PRIME DP - Unbound Medicine ER -