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Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction.
Chin Med J (Engl). 2017 5th Jan 2017; 130(1):77-82.CM

Abstract

BACKGROUND

The level of high-density lipoprotein cholesterol (HDL-C) is an important risk indicator and used in risk factor counting and quantitative risk assessment; however, the effect of HDL-C in young male patients with acute myocardial infarction (AMI) is unclear. The aim of this study was to investigate the effect of HDL-C in young male patients.

METHODS

We recruited 267 consecutive young male patients (≤44 years) diagnosed with AMI. Other 247 participants free from coronary heart disease were enrolled as controls. HDL-C levels of AMI patients and controls were evaluated to analyze the predictive value on AMI. According to the cutoff point of 1.04 mmol/L HDL-C, patients of AMI were divided into two subgroups (normal HDL-C group and low HDL-C group) and were followed up for 2 years. Clinical end points included all major adverse coronary events (MACEs): the main cause of death, nonfatal myocardial infarction, readmissions for acute coronary syndrome, arrhythmias, or revascularization. The prognostic value of HDL-C was evaluated using Cox regression according to MACE.

RESULTS

Patients of AMI had decreased proportion in normal HDL-C group compared to controls (47.2% vs. 57.9%; P = 0.017). Logistic regression analysis showed that there was an inverse relationship between HDL-C and AMI in young males. In the low HDL-C subgroup of AMI patients (n = 141), 34 (24.1%) patients experienced a MACE during the 2-year follow-up, compared with 15 (11.9%) patients in normal HDL-C subgroup (n = 126). The Cox regression analysis showed that HDL-C was an independent predictor of a MACE during the follow-up period (hazard ratio = 0.354, P = 0.006).

CONCLUSION

HDL-C was an important parameter for predicting the risk and the clinical outcomes of AMI in young male patients.

Authors+Show Affiliations

Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28051027

Citation

Li, Zhao, et al. "Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients With Acute Myocardial Infarction." Chinese Medical Journal, vol. 130, no. 1, 2017, pp. 77-82.
Li Z, Huang J, Li N. Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction. Chin Med J (Engl). 2017;130(1):77-82.
Li, Z., Huang, J., & Li, N. (2017). Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction. Chinese Medical Journal, 130(1), 77-82. https://doi.org/10.4103/0366-6999.196581
Li Z, Huang J, Li N. Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients With Acute Myocardial Infarction. Chin Med J (Engl). 2017 5th Jan 2017;130(1):77-82. PubMed PMID: 28051027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction. AU - Li,Zhao, AU - Huang,Ji, AU - Li,Nan, PY - 2017/1/5/entrez PY - 2017/1/5/pubmed PY - 2017/3/14/medline SP - 77 EP - 82 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 130 IS - 1 N2 - BACKGROUND: The level of high-density lipoprotein cholesterol (HDL-C) is an important risk indicator and used in risk factor counting and quantitative risk assessment; however, the effect of HDL-C in young male patients with acute myocardial infarction (AMI) is unclear. The aim of this study was to investigate the effect of HDL-C in young male patients. METHODS: We recruited 267 consecutive young male patients (≤44 years) diagnosed with AMI. Other 247 participants free from coronary heart disease were enrolled as controls. HDL-C levels of AMI patients and controls were evaluated to analyze the predictive value on AMI. According to the cutoff point of 1.04 mmol/L HDL-C, patients of AMI were divided into two subgroups (normal HDL-C group and low HDL-C group) and were followed up for 2 years. Clinical end points included all major adverse coronary events (MACEs): the main cause of death, nonfatal myocardial infarction, readmissions for acute coronary syndrome, arrhythmias, or revascularization. The prognostic value of HDL-C was evaluated using Cox regression according to MACE. RESULTS: Patients of AMI had decreased proportion in normal HDL-C group compared to controls (47.2% vs. 57.9%; P = 0.017). Logistic regression analysis showed that there was an inverse relationship between HDL-C and AMI in young males. In the low HDL-C subgroup of AMI patients (n = 141), 34 (24.1%) patients experienced a MACE during the 2-year follow-up, compared with 15 (11.9%) patients in normal HDL-C subgroup (n = 126). The Cox regression analysis showed that HDL-C was an independent predictor of a MACE during the follow-up period (hazard ratio = 0.354, P = 0.006). CONCLUSION: HDL-C was an important parameter for predicting the risk and the clinical outcomes of AMI in young male patients. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/28051027/Predictive_and_Prognostic_Value_of_High_density_Lipoprotein_Cholesterol_in_Young_Male_Patients_with_Acute_Myocardial_Infarction_ L2 - https://doi.org/10.4103/0366-6999.196581 DB - PRIME DP - Unbound Medicine ER -