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Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica.
Chem Biodivers. 2017 Apr; 14(4)CB

Abstract

Phytochemical investigation on the barks of Betula platyphylla var. japonica (Betulaceae) was carried out, resulting in the isolation and identification of three new triterpenoids, 27-O-cis-caffeoylcylicodiscic acid (1), 27-O-cis-feruloylcylicodiscic acid (2), and 27-O-cis-caffeoylmyricerol (3), along with six known triterpenoids, obtusilinin (4), winchic acid (5), 27-O-trans-caffeoylcylicodiscic acid (6), uncarinic acid E (7), myriceric acid B (8), and 3-O-trans-caffeoyloleanolic acid (9). The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. All of the isolated compounds were evaluated for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Compounds 2, 6, 8, and 9 exhibited potent cytotoxicity against all of the tumor cells tested (IC50 < 10.0 μm), while compounds 3, 4, 5, and 7 showed moderate cytotoxicity against all of the tumor cells tested (IC50 < 20.0 μm).

Authors+Show Affiliations

School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.Korea Research Institute of Chemical Technology, Deajeon, 305-600, Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28052515

Citation

Eom, Hee Jeong, et al. "Cytotoxic Triterpenoids From the Barks of Betula Platyphylla Var. Japonica." Chemistry & Biodiversity, vol. 14, no. 4, 2017.
Eom HJ, Kang HR, Choi SU, et al. Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chem Biodivers. 2017;14(4).
Eom, H. J., Kang, H. R., Choi, S. U., & Kim, K. H. (2017). Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chemistry & Biodiversity, 14(4). https://doi.org/10.1002/cbdv.201600400
Eom HJ, et al. Cytotoxic Triterpenoids From the Barks of Betula Platyphylla Var. Japonica. Chem Biodivers. 2017;14(4) PubMed PMID: 28052515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. AU - Eom,Hee Jeong, AU - Kang,Hee Rae, AU - Choi,Sang Un, AU - Kim,Ki Hyun, Y1 - 2017/03/23/ PY - 2016/11/04/received PY - 2017/01/03/accepted PY - 2017/1/5/pubmed PY - 2017/4/25/medline PY - 2017/1/5/entrez KW - Betula platyphylla KW - Betulaceae KW - Cytotoxic activities KW - Triterpenoids JF - Chemistry & biodiversity JO - Chem Biodivers VL - 14 IS - 4 N2 - Phytochemical investigation on the barks of Betula platyphylla var. japonica (Betulaceae) was carried out, resulting in the isolation and identification of three new triterpenoids, 27-O-cis-caffeoylcylicodiscic acid (1), 27-O-cis-feruloylcylicodiscic acid (2), and 27-O-cis-caffeoylmyricerol (3), along with six known triterpenoids, obtusilinin (4), winchic acid (5), 27-O-trans-caffeoylcylicodiscic acid (6), uncarinic acid E (7), myriceric acid B (8), and 3-O-trans-caffeoyloleanolic acid (9). The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. All of the isolated compounds were evaluated for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Compounds 2, 6, 8, and 9 exhibited potent cytotoxicity against all of the tumor cells tested (IC50 < 10.0 μm), while compounds 3, 4, 5, and 7 showed moderate cytotoxicity against all of the tumor cells tested (IC50 < 20.0 μm). SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/28052515/Cytotoxic_Triterpenoids_from_the_Barks_of_Betula_platyphylla_var__japonica_ L2 - https://doi.org/10.1002/cbdv.201600400 DB - PRIME DP - Unbound Medicine ER -