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A prospective study of nutritional factors and hypertension among US women.

Abstract

The relation of various nutritional factors with hypertension was examined prospectively among 58,218 predominantly white US female registered nurses, aged 34-59 years. In 1980, all women completed an independently validated dietary questionnaire. During 4 years of follow-up, 3,275 women reported a diagnosis of hypertension; the validity of the self-report was shown in a subsample. Age, relative weight, and alcohol consumption were the strongest predictors for the development of hypertension. Dietary calcium and magnesium had independent and significant inverse associations with hypertension. For women with a calcium intake of at least 800 mg/day, the relative risk of hypertension was 0.78 (95% confidence interval, 0.69-0.88) when compared with an intake of less than 400 mg/day. The relative risk for magnesium intake of 300 mg/day or more compared with an intake of less than 200 mg/day was 0.77 (95% confidence interval, 0.67-0.88). For women with high intakes of both calcium and magnesium compared with those having low intakes of both, the relative risk of hypertension was 0.65 (95% confidence interval, 0.53-0.80). No independent associations with hypertension were observed for intakes of potassium, fiber, and saturated and polyunsaturated fatty acids. These prospective findings add to the growing evidence to support the need for randomized trials to determine whether there is a protective role of dietary calcium and magnesium in the regulation of blood pressure.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Erasmus University School of Medicine, Rotterdam, The Netherlands.

    , , , , , ,

    Source

    Circulation 80:5 1989 Nov pg 1320-7

    MeSH

    Adult
    Alcohol Drinking
    Body Weight
    Calcium, Dietary
    Cohort Studies
    Diet Surveys
    Energy Intake
    Female
    Humans
    Hypertension
    Magnesium
    Middle Aged
    Nurses
    Prospective Studies
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    2805268

    Citation

    Witteman, J C., et al. "A Prospective Study of Nutritional Factors and Hypertension Among US Women." Circulation, vol. 80, no. 5, 1989, pp. 1320-7.
    Witteman JC, Willett WC, Stampfer MJ, et al. A prospective study of nutritional factors and hypertension among US women. Circulation. 1989;80(5):1320-7.
    Witteman, J. C., Willett, W. C., Stampfer, M. J., Colditz, G. A., Sacks, F. M., Speizer, F. E., ... Hennekens, C. H. (1989). A prospective study of nutritional factors and hypertension among US women. Circulation, 80(5), pp. 1320-7.
    Witteman JC, et al. A Prospective Study of Nutritional Factors and Hypertension Among US Women. Circulation. 1989;80(5):1320-7. PubMed PMID: 2805268.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of nutritional factors and hypertension among US women. AU - Witteman,J C, AU - Willett,W C, AU - Stampfer,M J, AU - Colditz,G A, AU - Sacks,F M, AU - Speizer,F E, AU - Rosner,B, AU - Hennekens,C H, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 1320 EP - 7 JF - Circulation JO - Circulation VL - 80 IS - 5 N2 - The relation of various nutritional factors with hypertension was examined prospectively among 58,218 predominantly white US female registered nurses, aged 34-59 years. In 1980, all women completed an independently validated dietary questionnaire. During 4 years of follow-up, 3,275 women reported a diagnosis of hypertension; the validity of the self-report was shown in a subsample. Age, relative weight, and alcohol consumption were the strongest predictors for the development of hypertension. Dietary calcium and magnesium had independent and significant inverse associations with hypertension. For women with a calcium intake of at least 800 mg/day, the relative risk of hypertension was 0.78 (95% confidence interval, 0.69-0.88) when compared with an intake of less than 400 mg/day. The relative risk for magnesium intake of 300 mg/day or more compared with an intake of less than 200 mg/day was 0.77 (95% confidence interval, 0.67-0.88). For women with high intakes of both calcium and magnesium compared with those having low intakes of both, the relative risk of hypertension was 0.65 (95% confidence interval, 0.53-0.80). No independent associations with hypertension were observed for intakes of potassium, fiber, and saturated and polyunsaturated fatty acids. These prospective findings add to the growing evidence to support the need for randomized trials to determine whether there is a protective role of dietary calcium and magnesium in the regulation of blood pressure. SN - 0009-7322 UR - https://www.unboundmedicine.com/medline/citation/2805268/A_prospective_study_of_nutritional_factors_and_hypertension_among_US_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2805268.ui DB - PRIME DP - Unbound Medicine ER -