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Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Am J Clin Nutr 2017; 105(2):476-484AJ

Abstract

BACKGROUND

There is little information about the associations of intakes of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline in general populations or in carriers of apolipoprotein E ɛ4 (APO-E4), a major risk factor for dementia.

OBJECTIVE

We investigated the associations of cholesterol and egg intakes with incident dementia, Alzheimer disease (AD), and cognitive performance in middle-aged and older men from Eastern Finland.

DESIGN

A total of 2497 dementia-free men, aged 42-60 y in 1984-1989 at the baseline examinations of the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study, were included in the study. Information on the apolipoprotein E (Apo-E) phenotype was available for 1259 men. Data on cognitive performance tests at the 4-y re-examinations were available for 480 men. Dietary intakes were assessed with the use of 4-d food records at baseline. Dementia and AD diagnoses were based on Finnish health registers. Cox regression and ANCOVA were used for the analyses.

RESULTS

During the 21.9-y follow-up, 337 men were diagnosed with dementia, and 266 men were diagnosed with AD. Neither cholesterol nor egg intake was associated with a higher risk of incident dementia or AD. For example, when evaluated continuously, each intake of 100 mg cholesterol/d was associated with a multivariable-adjusted HR of 0.90 (95% CI: 0.79, 1.02) for incident dementia, and each additional 0.5 egg (27 g)/d was associated with an HR of 0.89 (95% CI: 0.78, 1.01). However, egg intake was associated with better performance on neuropsychological tests of the frontal lobe and executive functioning, the Trail Making Test, and the Verbal Fluency Test. The Apo-E4 phenotype did not modify the associations of cholesterol or egg intake (P-interactions > 0.11).

CONCLUSIONS

Neither cholesterol nor egg intake is associated with an increased risk of incident dementia or AD in Eastern Finnish men. Instead, moderate egg intake may have a beneficial association with certain areas of cognitive performance.

Authors+Show Affiliations

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and.Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; and jyrki.virtanen@uef.fi.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28052883

Citation

Ylilauri, Maija Pt, et al. "Association of Dietary Cholesterol and Egg Intakes With the Risk of Incident Dementia or Alzheimer Disease: the Kuopio Ischaemic Heart Disease Risk Factor Study." The American Journal of Clinical Nutrition, vol. 105, no. 2, 2017, pp. 476-484.
Ylilauri MP, Voutilainen S, Lönnroos E, et al. Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2017;105(2):476-484.
Ylilauri, M. P., Voutilainen, S., Lönnroos, E., Mursu, J., Virtanen, H. E., Koskinen, T. T., ... Virtanen, J. K. (2017). Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American Journal of Clinical Nutrition, 105(2), pp. 476-484. doi:10.3945/ajcn.116.146753.
Ylilauri MP, et al. Association of Dietary Cholesterol and Egg Intakes With the Risk of Incident Dementia or Alzheimer Disease: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2017;105(2):476-484. PubMed PMID: 28052883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study. AU - Ylilauri,Maija Pt, AU - Voutilainen,Sari, AU - Lönnroos,Eija, AU - Mursu,Jaakko, AU - Virtanen,Heli Ek, AU - Koskinen,Timo T, AU - Salonen,Jukka T, AU - Tuomainen,Tomi-Pekka, AU - Virtanen,Jyrki K, Y1 - 2017/01/04/ PY - 2016/10/03/received PY - 2016/12/01/accepted PY - 2017/1/6/pubmed PY - 2017/6/28/medline PY - 2017/1/6/entrez KW - Alzheimer disease KW - apolipoprotein E4 KW - cholesterol KW - cognitive function KW - cognitive performance KW - dementia KW - eggs KW - population study SP - 476 EP - 484 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 105 IS - 2 N2 - BACKGROUND: There is little information about the associations of intakes of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline in general populations or in carriers of apolipoprotein E ɛ4 (APO-E4), a major risk factor for dementia. OBJECTIVE: We investigated the associations of cholesterol and egg intakes with incident dementia, Alzheimer disease (AD), and cognitive performance in middle-aged and older men from Eastern Finland. DESIGN: A total of 2497 dementia-free men, aged 42-60 y in 1984-1989 at the baseline examinations of the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study, were included in the study. Information on the apolipoprotein E (Apo-E) phenotype was available for 1259 men. Data on cognitive performance tests at the 4-y re-examinations were available for 480 men. Dietary intakes were assessed with the use of 4-d food records at baseline. Dementia and AD diagnoses were based on Finnish health registers. Cox regression and ANCOVA were used for the analyses. RESULTS: During the 21.9-y follow-up, 337 men were diagnosed with dementia, and 266 men were diagnosed with AD. Neither cholesterol nor egg intake was associated with a higher risk of incident dementia or AD. For example, when evaluated continuously, each intake of 100 mg cholesterol/d was associated with a multivariable-adjusted HR of 0.90 (95% CI: 0.79, 1.02) for incident dementia, and each additional 0.5 egg (27 g)/d was associated with an HR of 0.89 (95% CI: 0.78, 1.01). However, egg intake was associated with better performance on neuropsychological tests of the frontal lobe and executive functioning, the Trail Making Test, and the Verbal Fluency Test. The Apo-E4 phenotype did not modify the associations of cholesterol or egg intake (P-interactions > 0.11). CONCLUSIONS: Neither cholesterol nor egg intake is associated with an increased risk of incident dementia or AD in Eastern Finnish men. Instead, moderate egg intake may have a beneficial association with certain areas of cognitive performance. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28052883/Association_of_dietary_cholesterol_and_egg_intakes_with_the_risk_of_incident_dementia_or_Alzheimer_disease:_the_Kuopio_Ischaemic_Heart_Disease_Risk_Factor_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.116.146753 DB - PRIME DP - Unbound Medicine ER -