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Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis.
BMC Neurol. 2017 Jan 05; 17(1):1.BN

Abstract

BACKGROUND

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases of anti-NMDAR encephalitis with incomplete forms, 3 cases of which were accompanied by neuromyelitis optica spectrum disorder or neurosyphilis respectively.

CASE PRESENTATION

A 33-year-old man presented with dysarthria, movement disorder and occasional seizures. He had 6 relapses in 28 years. When suffered from upper respiratory tract syndrome, he developed behavioral and consciousness impairment. Cranial MRI was normal. Viral PCR studies and oncologic work-up were negative. Anti-NMDAR antibody was detected in CSF and serum. A 21-year-old female manifested dizziness and diplopia ten months and six months before, respectively. Both responded to steroid therapy and improved completely. This time she presented with progressive left limb and facial anesthesia, walking and holding unsteadily. Spinal cord MRI follow-up showed abnormality of medulla oblongata and cervical cord(C1). Anti-AQP4 and anti-NMDAR were positive in CSF. Steroid-pulse therapy ameliorated her symptoms. A 37-year-old male experienced worsening vision. He was confirmed neurosyphilis since the CSF tests for syphilis were positive. Protein was elevated and the oligoclonal IgG bands(OB) and anti-NMDAR was positive in CSF. Anti-aquaporin 4(AQP4) antibodies and NMO-IgG were negative. Cranial MRI showed high FLAIR signal on frontal lobe and low T2 signal adjacent to the right cornu posterious ventriculi lateralis. Treatment for neurosyphlis was commenced with gradual improvement. A 39-year-old male, developed serious behavioral and psychiatric symptoms. Examination showed abnormal pupils and unsteady gait. He was confirmed neurosyphilis according to the CSF tests for syphilis. Anti-NMDAR was positive in CSF and serum. Cranial MRI showed lateral ventricles and the third ventricle enlargement and signal abnormality involving bilateral temporal lobe, corona radiate and centrum semiovale. PenicillinG, pulsed methylprednisolone and intravenous immunoglobulin was administered. He was stable.

CONCLUSION

Anti-NMDAR encephalitis can present in atypical types. When relapsing, it may present with partial aspects or with isolated symptoms of the full-blown syndrome. Anti-NMDAR encephalitis may be related to neuromyelitis optica spectrum disorder or neurosyphilis.

Authors+Show Affiliations

Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China. ruiyang56@aliyun.com.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28056870

Citation

Qin, Kaiyu, et al. "Anti-N-methyl-D-aspartate receptor(NMDAR) Antibody Encephalitis Presents in Atypical Types and Coexists With Neuromyelitis Optica Spectrum Disorder or Neurosyphilis." BMC Neurology, vol. 17, no. 1, 2017, p. 1.
Qin K, Wu W, Huang Y, et al. Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis. BMC Neurol. 2017;17(1):1.
Qin, K., Wu, W., Huang, Y., Xu, D., Zhang, L., Zheng, B., Jiang, M., Kou, C., Gao, J., Li, W., Zhang, J., Wang, S., Luan, Y., Yan, C., Xu, D., & Zheng, X. (2017). Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis. BMC Neurology, 17(1), 1. https://doi.org/10.1186/s12883-016-0787-9
Qin K, et al. Anti-N-methyl-D-aspartate receptor(NMDAR) Antibody Encephalitis Presents in Atypical Types and Coexists With Neuromyelitis Optica Spectrum Disorder or Neurosyphilis. BMC Neurol. 2017 Jan 5;17(1):1. PubMed PMID: 28056870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis. AU - Qin,Kaiyu, AU - Wu,Wenqing, AU - Huang,Yuming, AU - Xu,Dongmei, AU - Zhang,Lei, AU - Zheng,Bowen, AU - Jiang,Meijuan, AU - Kou,Cheng, AU - Gao,Junhua, AU - Li,Wurong, AU - Zhang,Jinglin, AU - Wang,Sumei, AU - Luan,Yanfei, AU - Yan,Chaoling, AU - Xu,Dan, AU - Zheng,Xinmei, Y1 - 2017/01/05/ PY - 2016/04/20/received PY - 2016/12/21/accepted PY - 2017/1/7/entrez PY - 2017/1/7/pubmed PY - 2017/2/28/medline KW - Anti-N-methyl-D-aspartate receptor(NMDAR) KW - Atypical types KW - Neuromyelitis optica spectrum disorder KW - Neurosyphilis SP - 1 EP - 1 JF - BMC neurology JO - BMC Neurol VL - 17 IS - 1 N2 - BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases of anti-NMDAR encephalitis with incomplete forms, 3 cases of which were accompanied by neuromyelitis optica spectrum disorder or neurosyphilis respectively. CASE PRESENTATION: A 33-year-old man presented with dysarthria, movement disorder and occasional seizures. He had 6 relapses in 28 years. When suffered from upper respiratory tract syndrome, he developed behavioral and consciousness impairment. Cranial MRI was normal. Viral PCR studies and oncologic work-up were negative. Anti-NMDAR antibody was detected in CSF and serum. A 21-year-old female manifested dizziness and diplopia ten months and six months before, respectively. Both responded to steroid therapy and improved completely. This time she presented with progressive left limb and facial anesthesia, walking and holding unsteadily. Spinal cord MRI follow-up showed abnormality of medulla oblongata and cervical cord(C1). Anti-AQP4 and anti-NMDAR were positive in CSF. Steroid-pulse therapy ameliorated her symptoms. A 37-year-old male experienced worsening vision. He was confirmed neurosyphilis since the CSF tests for syphilis were positive. Protein was elevated and the oligoclonal IgG bands(OB) and anti-NMDAR was positive in CSF. Anti-aquaporin 4(AQP4) antibodies and NMO-IgG were negative. Cranial MRI showed high FLAIR signal on frontal lobe and low T2 signal adjacent to the right cornu posterious ventriculi lateralis. Treatment for neurosyphlis was commenced with gradual improvement. A 39-year-old male, developed serious behavioral and psychiatric symptoms. Examination showed abnormal pupils and unsteady gait. He was confirmed neurosyphilis according to the CSF tests for syphilis. Anti-NMDAR was positive in CSF and serum. Cranial MRI showed lateral ventricles and the third ventricle enlargement and signal abnormality involving bilateral temporal lobe, corona radiate and centrum semiovale. PenicillinG, pulsed methylprednisolone and intravenous immunoglobulin was administered. He was stable. CONCLUSION: Anti-NMDAR encephalitis can present in atypical types. When relapsing, it may present with partial aspects or with isolated symptoms of the full-blown syndrome. Anti-NMDAR encephalitis may be related to neuromyelitis optica spectrum disorder or neurosyphilis. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/28056870/Anti_N_methyl_D_aspartate_receptor_NMDAR__antibody_encephalitis_presents_in_atypical_types_and_coexists_with_neuromyelitis_optica_spectrum_disorder_or_neurosyphilis_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0787-9 DB - PRIME DP - Unbound Medicine ER -