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Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography.
Br J Ophthalmol. 2017 08; 101(8):1032-1037.BJ

Abstract

PURPOSE

To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT).

METHODS

We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT.

RESULTS

AQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab-/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab-/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab-/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab-/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered.

CONCLUSIONS

AQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO.

Authors+Show Affiliations

Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Neurology Department, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28057643

Citation

Peng, Chun Xia, et al. "Retinal Segmented Layers With Strong Aquaporin-4 Expression Suffered More Injuries in Neuromyelitis Optica Spectrum Disorders Compared With Optic Neuritis With Aquaporin-4 Antibody Seronegativity Detected By Optical Coherence Tomography." The British Journal of Ophthalmology, vol. 101, no. 8, 2017, pp. 1032-1037.
Peng CX, Li HY, Wang W, et al. Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography. Br J Ophthalmol. 2017;101(8):1032-1037.
Peng, C. X., Li, H. Y., Wang, W., Wang, J. Q., Wang, L., Xu, Q. G., Cao, S. S., Zhou, H. F., Zhao, S., & Wei, S. H. (2017). Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography. The British Journal of Ophthalmology, 101(8), 1032-1037. https://doi.org/10.1136/bjophthalmol-2016-309412
Peng CX, et al. Retinal Segmented Layers With Strong Aquaporin-4 Expression Suffered More Injuries in Neuromyelitis Optica Spectrum Disorders Compared With Optic Neuritis With Aquaporin-4 Antibody Seronegativity Detected By Optical Coherence Tomography. Br J Ophthalmol. 2017;101(8):1032-1037. PubMed PMID: 28057643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography. AU - Peng,Chun Xia, AU - Li,Hong Yang, AU - Wang,Wei, AU - Wang,Jun Qing, AU - Wang,Lei, AU - Xu,Quan Gang, AU - Cao,Shan Shan, AU - Zhou,Huan Fen, AU - Zhao,Shuo, AU - Wei,Shi Hui, Y1 - 2017/01/05/ PY - 2016/07/27/received PY - 2016/11/17/revised PY - 2016/12/05/accepted PY - 2017/1/7/pubmed PY - 2017/7/27/medline PY - 2017/1/7/entrez KW - Diagnostic tests/Investigation KW - Imaging KW - Optic Nerve KW - Pathology KW - Retina SP - 1032 EP - 1037 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 101 IS - 8 N2 - PURPOSE: To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). METHODS: We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT. RESULTS: AQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab-/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab-/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab-/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab-/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered. CONCLUSIONS: AQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/28057643/Retinal_segmented_layers_with_strong_aquaporin_4_expression_suffered_more_injuries_in_neuromyelitis_optica_spectrum_disorders_compared_with_optic_neuritis_with_aquaporin_4_antibody_seronegativity_detected_by_optical_coherence_tomography_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=28057643 DB - PRIME DP - Unbound Medicine ER -